Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.Matsuoka S., Huang M., Elledge S.J.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA]CategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 282:1893-1897 (1998)Cited in2Mapped to5
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]StrainNMRITissueMammary glandCategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.Hirao A., Cheung A., Duncan G., Girard P.M., Elia A.J., Wakeham A., Okada H., Sarkissian T., Wong J.A.[...], Mak T.W.View abstractCited forDISRUPTION PHENOTYPE, FUNCTION IN APOPTOSIS, TISSUE SPECIFICITYCategoriesFunction, Expression, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell. Biol. 22:6521-6532 (2002)Cited in1Mapped to24
A novel recurrent CHEK2 Y390C mutation identified in high-risk Chinese breast cancer patients impairs its activity and is associated with increased breast cancer risk.Wang N., Ding H., Liu C., Li X., Wei L., Yu J., Liu M., Ying M., Gao W.[...], Wang Y.View abstractCited forFUNCTION, MUTAGENESIS OF TYR-394CategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCOncogene 34:5198-5205 (2015)Cited in2Mapped to4
BRCA1 safeguards genome integrity by activating chromosome asynapsis checkpoint to eliminate recombination-defective oocytes.Bai L., Li P., Xiang Y., Jiao X., Chen J., Song L., Liang Z., Liu Y., Zhu Y., Lu L.Y.View abstractSourceMGI: 1355321PubMedEurope PMCProc Natl Acad Sci U S A 121:e2401386121-e2401386121 (2024)Mapped to28
Genetic determinants of micronucleus formation in vivo.Adams D.J., Barlas B., McIntyre R.E., Salguero I., van der Weyden L., Barros A., Vicente J.R., Karimpour N., Haider A.[...], White J.K.View abstractSourceMGI: 1355321PubMedEurope PMCNature 627:130-136 (2024)Mapped to99+
CHEK2 deficiency increase the response to PD-1 inhibitors by affecting the tumor immune microenvironment.Xu P., Gao Y., Jiang S., Cui Y., Xie Y., Kang Z., Chen Y.X., Sun D., Fang J.Y.View abstractAnnotationCHEK2 deficiency increase the response to PD-1 inhibitors by affecting the tumor immune microenvironment.SourceGeneRif: 50883PubMedEurope PMCCancer Lett 588:216595-216595 (2024)Mapped to2
Checkpoint kinase 2 controls insulin secretion and glucose homeostasis.Chong A.C.N., Vandana J.J., Jeng G., Li G., Meng Z., Duan X., Zhang T., Qiu Y., Duran-Struuck R.[...], Chen S.View abstractAnnotationCheckpoint kinase 2 controls insulin secretion and glucose homeostasis.SourceGeneRif: 50883PubMedEurope PMCNat Chem Biol 20:566-576 (2024)Mapped to7
ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress.Liu J., Lu S., Zheng L., Guo Q., Cao L., Xiao Y., Chen D., Zou Y., Liu X.[...], Cao L.View abstractSourceMGI: 1355321PubMedEurope PMCCell Rep. 42:113402-113402 (2023)Cited in3Mapped to5
CHEK2 signaling is the key regulator of oocyte survival after chemotherapy.Emori C., Boucher Z., Bolcun-Filas E.View abstractSourceMGI: 1355321PubMedEurope PMCSci Adv 9:eadg0898-eadg0898 (2023)Mapped to25
MiR-669b-5p inhibits the Alzheimer's disease development via regulation of CHEK2 in Neuro2a APPSwe/Delta9 cells.A M., Bai Y., Hu B., Su Y., Yuan X.View abstractAnnotationMiR-669b-5p inhibits the Alzheimer's disease development via regulation of CHEK2 in Neuro2a APPSwe/Delta9 cells.SourceGeneRif: 50883PubMedEurope PMCCell Mol Biol (Noisy-le-grand) 69:118-124 (2023)Mapped to2
Maternal <i>Toxoplasma gondii</i> infection affects proliferation, differentiation and cell cycle regulation of retinal neural progenitor cells in mouse embryo.de Campos V.S., Magalhaes C.F., da Rosa B.G., Dos Santos C.M., Fragel-Madeira L., Figueiredo D.P., Calaza K.C., Adesse D.View abstractSourceMGI: 1355321PubMedEurope PMCFront Cell Neurosci 17:1211446-1211446 (2023)Mapped to32
Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness.Oropeza E., Seker S., Carrel S., Mazumder A., Lozano D., Jimenez A., VandenHeuvel S.N., Noltensmeyer D.A., Punturi N.B.[...], Haricharan S.View abstractSourceMGI: 1355321PubMedEurope PMCSci Adv 9:eadf2860-eadf2860 (2023)Mapped to5
Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade.Dmello C., Zhao J., Chen L., Gould A., Castro B., Arrieta V.A., Zhang D.Y., Kim K.S., Kanojia D.[...], Sonabend A.M.View abstractAnnotationCheckpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade.SourceGeneRif: 50883, MGI: 1355321PubMedEurope PMCNat Commun 14:1566-1566 (2023)Mapped to18
Cell cycle kinase CHEK2 in macrophages alleviates the inflammatory response to <i>Staphylococcus aureus</i>-induced pneumonia.Xie F., Chen R., Zhao J., Xu C., Zan C., Yue B., Tian W., Yi W.View abstractAnnotationCell cycle kinase CHEK2 in macrophages alleviates the inflammatory response to Staphylococcus aureus-induced pneumonia.CategoriesFunction, ExpressionSourceGeneRif: 50883PubMedEurope PMCExp Lung Res 48:53-60 (2022)Mapped to2
Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons.Akagawa R., Nabeshima Y.I., Kawauchi T.View abstractCategoryFunctionSourceMGI: 1355321PubMedEurope PMCFront Cell Dev Biol 9:753175-753175 (2021)Mapped to99+
Genetic insights into biological mechanisms governing human ovarian ageing.Biobank-based Integrative Omics Study (BIOS) ConsortiumRuth K.S., Day F.R., Hussain J., Martinez-Marchal A., Aiken C.E., Azad A., Thompson D.J., Knoblochova L., Abe H.[...], Perry J.R.B.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1355321PubMedEurope PMCNature 596:393-397 (2021)Mapped to9
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.Bedogni F., Hevner R.F.View abstractSourceMGI: 1355321PubMedEurope PMCFront Mol Neurosci 14:686034-686034 (2021)Mapped to99+
Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin.Xu C., Shen W.B., Reece E.A., Hasuwa H., Harman C., Kaushal S., Yang P.View abstractCategoryFunctionSourceMGI: 1355321PubMedEurope PMCSci Adv 7:eabf5089-eabf5089 (2021)Mapped to72
Alteration of DNA Damage Response Causes Cleft Palate.Yamaguchi H., Kitami K., Wu X., He L., Wang J., Wang B., Komatsu Y.View abstractCategoryFunctionSourceMGI: 1355321PubMedEurope PMCFront Physiol 12:649492-649492 (2021)Mapped to35
Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex.Ulmke P.A., Sakib M.S., Ditte P., Sokpor G., Kerimoglu C., Pham L., Xie Y., Mao X., Rosenbusch J.[...], Tuoc T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1355321PubMedEurope PMCStem Cell Reports 16:968-984 (2021)Mapped to99+
Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation.Xiang J., Chen C., Liu R., Gou D., Chang L., Deng H., Gao Q., Zhang W., Tuo L.[...], Tang N.View abstractAnnotationGluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation.CategoriesFunction, PTM / ProcessingSourceGeneRif: 50883, MGI: 1355321PubMedEurope PMCJ Clin Invest 131:144703-144703 (2021)Mapped to15
Nbs1-mediated DNA damage repair pathway regulates haematopoietic stem cell development and embryonic haematopoiesis.Chen Y., Sun J., Ju Z., Wang Z.Q., Li T.View abstractCategoriesFunction, PTM / ProcessingSourceMGI: 1355321PubMedEurope PMCCell Prolif 54:e12972-e12972 (2021)Mapped to40
p53-Independent Induction of p21 Fails to Control Regeneration and Hepatocarcinogenesis in a Murine Liver Injury Model.Buitrago-Molina L.E., Marhenke S., Becker D., Geffers R., Itzel T., Teufel A., Jaeschke H., Lechel A., Unger K.[...], Vogel A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1355321PubMedEurope PMCCell Mol Gastroenterol Hepatol 11:1387-1404 (2021)Mapped to24
SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis.Atkins A., Xu M.J., Li M., Rogers N.P., Pryzhkova M.V., Jordan P.W.View abstractCategoryFunctionSourceMGI: 1355321PubMedEurope PMCElife 9:e61171-e61171 (2020)Mapped to87