Q9Z1Y9 · IOD2_MOUSE

  • Protein
    Type II iodothyronine deiodinase
  • Gene
    Dio2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.

Catalytic activity

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
4.4 nMT4

Features

Showing features for active site.

126620406080100120140160180200220240260
TypeIDPosition(s)Description
Active site130

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionthyroxine 5'-deiodinase activity
Biological Processbrown fat cell differentiation
Biological Processcellular lipid metabolic process
Biological Processhormone biosynthetic process
Biological Processpositive regulation of cold-induced thermogenesis
Biological Processthyroid hormone catabolic process
Biological Processthyroid hormone generation
Biological Processthyroid hormone metabolic process
Biological Processthyroid-stimulating hormone secretion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Type II iodothyronine deiodinase
  • EC number
  • Alternative names
    • 5DII
    • DIOII
    • Type 2 DI
    • Type-II 5'-deiodinase

Gene names

    • Name
      Dio2

Organism names

  • Taxonomic identifier
  • Strain
    • C3H/HeN
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9Z1Y9
  • Secondary accessions
    • Q05A70
    • Q9JHH1

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane10-34Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001543181-266Type II iodothyronine deiodinase

Post-translational modification

Ubiquitinated by MARCHF6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33 (By similarity).

Keywords

Proteomic databases

Expression

Tissue specificity

Expressed in mammary gland and in brain.

Gene expression databases

Interaction

Subunit

Interacts with USP20 and USP33. Interacts with MARCHF6 (By similarity).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the iodothyronine deiodinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    266
  • Mass (Da)
    29,929
  • Last updated
    2008-02-26 v4
  • Checksum
    B2FD28E171DC5486
MGLLSVDLLITLQILPVFFSNCLFLALYDSVILLKHVALLLSRSKSTRGEWRRMLTSEGLRCVWNSFLLDAYKQVKLGEDAPNSSVVHVSNPESGNNYASEKTADGAECHLLDFASAERPLVVNFGSATUPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQRRKIAYLGGKGPFSYNLQEVRSWLEKNFSKRUILD

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8Z1S5Q0A0A8Z1S5Q0_MOUSEDio2262

Features

Showing features for non-standard residue.

TypeIDPosition(s)Description
Non-standard residue130Selenocysteine
Non-standard residue263Selenocysteine

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF096875
EMBL· GenBank· DDBJ
AAD11422.1
EMBL· GenBank· DDBJ
mRNA
AF177196
EMBL· GenBank· DDBJ
AAD53113.1
EMBL· GenBank· DDBJ
mRNA
AF093137
EMBL· GenBank· DDBJ
AAF00069.2
EMBL· GenBank· DDBJ
mRNA
BC125383
EMBL· GenBank· DDBJ
AAI25384.1
EMBL· GenBank· DDBJ
mRNA
BC125385
EMBL· GenBank· DDBJ
AAI25386.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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