Q9Z1T1 · AP3B1_MOUSE
- ProteinAP-3 complex subunit beta-1
- GeneAp3b1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1105 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Publications for Q9Z1T1
WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction.
- AnnotationWNK4 inhibits NCC activity by diverting the cotransporter to the lysosome for degradation by way of an AP-3 transport carrier
- CategorySubcellular Location
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles.
- CategorySubcellular Location
- SourceMGI: 1333879
AP-1 and AP-3 mediate sorting of melanosomal and lysosomal membrane proteins into distinct post-Golgi trafficking pathways.
- AnnotationAP-1 and AP-3 are involved in the formation of distinct types of clathrin-coated vesicles each of which is characterized by the incorporation of specific cargo membrane proteins
- CategorySubcellular Location
- SourceGeneRif: 11774
Regulation of large dense-core vesicle volume and neurotransmitter content mediated by adaptor protein 3.
- CategorySubcellular Location
- SourceMGI: 1333879
Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain.
- Annotationthe functions of beta3A- and beta3B-containing complexes are distinct and divergent in brain
- CategoriesFunction, Subcellular Location
The neuronal form of adaptor protein-3 is required for synaptic vesicle formation from endosomes.
- CategoriesFunction, Expression, Subcellular Location
- SourceMGI: 1333879
Defective organellar membrane protein trafficking in Ap3b1-deficient cells.
- CategoriesPhenotypes & Variants, Subcellular Location
- SourceMGI: 1333879
Abnormal expression and subcellular distribution of subunit proteins of the AP-3 adaptor complex lead to platelet storage pool deficiency in the pearl mouse.
- CategorySubcellular Location
- SourceMGI: 1333879
- PubMed
- Europe PMC
- Blood 94:146-155 ()
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