Downregulation of senescence-associated secretory phenotype by knockdown of secreted frizzled-related protein 4 contributes to the prevention of skin aging.
these data show autocrine and paracrine effects of Sfrp4 in regulating osteoclast (OC) genesis and demonstrate that the increase in endosteal OCs seen in Sfrp4 (-/-) mice is a consequence of noncanonical Wnt/Ror2/Jnk signaling activation in OCs overriding the negative effect that activation of canonical Wnt/beta-catenin signaling has on OC genesis
miR-943-3p accelerated the progression of airway inflammation and remodeling in allergic asthma via suppressing the activity of SFRP4 through Wnt signaling pathway in asthma patients and OVA-induced mice.
Taken together our results suggest that SFRP4 acts to attenuate granulosa cell responsiveness to gonadotropins thereby decreasing follicle survival ovulatory rate and fertility.
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