Q9Z191 · EYA4_MOUSE

  • Protein
    Eyes absent homolog 4
  • Gene
    Eya4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for active site, binding site.

161650100150200250300350400450500550600
TypeIDPosition(s)Description
Active site352Nucleophile
Binding site352Mg2+ (UniProtKB | ChEBI)
Active site354Proton donor
Binding site354Mg2+ (UniProtKB | ChEBI)
Binding site580Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionmetal ion binding
Molecular Functionprotein tyrosine phosphatase activity
Biological Processcell differentiation
Biological Processchromatin organization
Biological ProcessDNA repair
Biological Processmiddle ear morphogenesis
Biological Processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Biological Processpositive regulation of DNA repair
Biological Processsensory perception of sound

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Eyes absent homolog 4
  • EC number

Gene names

    • Name
      Eya4

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9Z191
  • Secondary accessions
    • Q0VAV8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue, chain, cross-link.

TypeIDPosition(s)Description
Modified residue1N-acetylmethionine
ChainPRO_00002186521-616Eyes absent homolog 4
Cross-link14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue338Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

In the embryo, expressed mainly in the craniofacial mesenchyme, dermamyotome and limb.

Gene expression databases

Interaction

Subunit

Interacts with SIX3; translocates EYA4 from the cytoplasm to the nucleus and promotes activation of their target genes.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-66Disordered
Compositional bias49-66Polar residues
Region186-211Disordered
Compositional bias277-314Polar residues
Region277-345Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    616
  • Mass (Da)
    66,875
  • Last updated
    2011-07-27 v2
  • Checksum
    AC4B7E891AB7A6F3
MEDTQDLNEQSVKKTCPEADVSEPQNSRSMEMQDLASPHALVGGSDTPGSSKLDKSGLSSTSVTTNGTGVSLLAVKTEPLHSSESTTTTGDGALDTFTGSVITSSGYSPRSAQQYSPQLYPSKPYPHILSTPAAQTMSAYAGQTQYSGMQQPAVYTAYSQTGQPYSLPAYDLGVMLPAIKTESGLSQTQSPLQSGCLSYSPGFSTPQPGQTPYSYQMPGSSFAPSSTIYANNSVSNSTNFSSSQQDYPSYTAFGQNQYAQYYSASTYGAYMTSNNTADGTSSSTSTYQLQESLQGLTSQPGEFDTVQSPSTPIKDLDDRTCRSSGSKSRGRGRKNNPSPPPDSDLERVFVWDLDETIIVFHSLLTGSYAQKYGKDPPMAVTLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHAAASSANLCLPTGVRGGVDWMRKLAFRYRRVKELYNTYKNNVGGLLGPAKRDAWLQLRAEIEGLTDSWLTNALKSLSIISTRSNCVNVLVTTTQLIPALAKVLLYSLGGAFPIENIYSATKIGKESCFERIVSRFGTNITYVVIGDGRDEEHAANQHNMPFWRISSHSDLLALHQALELEYL

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1W2P721A0A1W2P721_MOUSEEya4639
A0A1W2P897A0A1W2P897_MOUSEEya474
Q8BY78Q8BY78_MOUSEEya4616

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias49-66Polar residues
Compositional bias277-314Polar residues
Sequence conflict337in Ref. 1; CAA76637

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y17115
EMBL· GenBank· DDBJ
CAA76637.1
EMBL· GenBank· DDBJ
mRNA
AJ007997
EMBL· GenBank· DDBJ
CAA07820.1
EMBL· GenBank· DDBJ
mRNA
CH466540
EMBL· GenBank· DDBJ
EDL04766.1
EMBL· GenBank· DDBJ
Genomic DNA
BC120899
EMBL· GenBank· DDBJ
AAI20900.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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