Q9Z143 · SEM4F_RAT

Function

function

Probable cell surface receptor that regulates oligodendroglial precursor cell migration (By similarity).
Might also regulate differentiation of oligodendroglial precursor cells (PubMed:21945643).
Has growth cone collapse activity against retinal ganglion-cell axons (PubMed:10051670).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentdendrite
Cellular Componentendoplasmic reticulum
Cellular Componentglutamatergic synapse
Cellular Componentmembrane
Cellular Componentperikaryon
Cellular Componentplasma membrane
Cellular Componentpostsynaptic density membrane
Cellular Componentpostsynaptic membrane
Cellular Componentsynapse
Molecular Functionchemorepellent activity
Molecular Functionsemaphorin receptor binding
Biological Processaxon guidance
Biological Processnegative chemotaxis
Biological Processnegative regulation of axon extension
Biological Processneural crest cell migration
Biological Processpositive regulation of cell migration
Biological Processretinal ganglion cell axon guidance
Biological Processsemaphorin-plexin signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Semaphorin-4F
  • Alternative names
    • Semaphorin-W (Sema W)

Gene names

    • Name
      Sema4f

Organism names

  • Taxonomic identifier
  • Strain
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q9Z143

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain40-665Extracellular
Transmembrane666-686Helical
Topological domain687-776Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond, modified residue.

TypeIDPosition(s)Description
Signal1-39
ChainPRO_000003233240-776Semaphorin-4F
Glycosylation69N-linked (GlcNAc...) asparagine
Disulfide bond117↔127
Glycosylation138N-linked (GlcNAc...) asparagine
Disulfide bond145↔154
Disulfide bond278↔389
Disulfide bond302↔348
Glycosylation514N-linked (GlcNAc...) asparagine
Disulfide bond518↔535
Disulfide bond527↔544
Disulfide bond592↔633
Modified residue724Phosphoserine
Modified residue726Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed at low levels in the developing embryo (PubMed:10051670).
Expressed at high levels in the lung and adult central nervous system, including the dorsal root ganglia (PubMed:10051670).

Gene expression databases

Interaction

Subunit

Interacts (via PDZ-binding motif) with DLG4/SAP90 (via PDZ domain 2); this interaction may promote translocation of DLG4/SAP90 to the membrane.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, motif.

TypeIDPosition(s)Description
Domain47-515Sema
Domain517-568PSI
Domain585-640Ig-like C2-type
Region702-741Disordered
Motif774-776PDZ-binding

Sequence similarities

Belongs to the semaphorin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    776
  • Mass (Da)
    84,298
  • Last updated
    1999-05-01 v1
  • Checksum
    20763182CC6C93CA
MLARAERPRPGPRPPPVFPFPPPLSLLLLLAILSAPVCGRVPRSVPRTSLPISEADSYLTRFAASHTYNYSALLVDPASHTLYVGARDSIFALTLPFSGERPRRIDWMVPETHRQNCRKKGKKEDECHNFIQILAIVNASHLLTCGTFAFDPKCGVIDVSSFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYTATVKNFLGTEPIISRAVGRAEDWIRTETLSSWLNAPAFVAAMVLSPAEWGDEDGDDEIFFFFTETSRVLDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASGVLQAMAELRPQPGAGTPIFYGIFSSQWEGAAISAVCAFRPQDIRAVLNGPFRELKHDCNRGLPVMDNEVPQPRPGECIANNMKLQQFGSSLSLPDRVLTFIRDHPLMDRPVFPADGRPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPEPQPVESMKLYHDWLLVGSHTEVTQVNTSNCGRLQSCSECILAQDPVCAWSFRLDACVAHAGEHRGMVQDIESADVSSLCPKEPGEHPVVFEVPVATVGHVVLPCSPSSAWASCVWHQPSGVTALTPRRDGLEVVVTPGAMGAYACECQEGGAARVVAAYSLVWGSQRGPSNRAHTVVGAGLVGFLLGVLAASLTLLLIGRRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPSPEDERLPLALGKRGSGFGGFPPPFLLDSCPSPAHIRLTGAPLATCDETSI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB002563
EMBL· GenBank· DDBJ
BAA75629.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp