Q9Z123 · SEM4F_MOUSE
- ProteinSemaphorin-4F
- GeneSema4f
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids777 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Probable cell surface receptor that regulates oligodendroglial precursor cell migration (PubMed:21945643).
Might also regulate differentiation of oligodendroglial precursor cells (By similarity).
Has growth cone collapse activity against retinal ganglion-cell axons (By similarity).
Might also regulate differentiation of oligodendroglial precursor cells (By similarity).
Has growth cone collapse activity against retinal ganglion-cell axons (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | dendrite | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | glutamatergic synapse | |
Cellular Component | membrane | |
Cellular Component | perikaryon | |
Cellular Component | plasma membrane | |
Cellular Component | postsynaptic density membrane | |
Cellular Component | postsynaptic membrane | |
Cellular Component | synapse | |
Molecular Function | chemorepellent activity | |
Molecular Function | semaphorin receptor binding | |
Biological Process | axon extension | |
Biological Process | axon guidance | |
Biological Process | negative chemotaxis | |
Biological Process | negative regulation of axon extension | |
Biological Process | neural crest cell migration | |
Biological Process | positive regulation of cell migration | |
Biological Process | retinal ganglion cell axon guidance | |
Biological Process | semaphorin-plexin signaling pathway |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSemaphorin-4F
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9Z123
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Note: Colocalizes with DLG4 at synapses.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 41-667 | Extracellular | ||||
Sequence: RVPRSVPRTSLPISEADSYLTRFAAPHTYNYSALLVDPASHTLYVGARDSIFALTLPFSGEKPRRIDWMVPETHRQNCRKKGKKEDECHNFIQILAIANASHLLTCGTFAFDPKCGVIDVSSFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYTATVKNFLGTEPIISRAVGRAEDWIRTETLSSWLNAPAFVAAMVLSPAEWGDEDGDDEIFFFFTETSRVLDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASGVLQDMTELRPQPGAGTPLFYGIFSSQWEGAAISAVCAFRPQDIRAVLNGPFRELKHDCNRGLPVMDNEVPQPRPGECITNNMKFQQFGSSLSLPDRVLTFIRDHPLMDRPVFPADGRPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPETQPVESMKLYHDWLLVGSHTEVTQVNTSNCGRLQSCSECILAQDPVCAWSFRLDACVAHAGEHRGMVQDIESADVSSLCPKEPGEHPVVFEVPVATVGHVVLPCSPSSAWASCVWHQPSGVTSLTPRRDGLEVVVTPGAMGAYACECQEGGAARVVAAYSLVWGSQRGPANRAHTVVG | ||||||
Transmembrane | 668-688 | Helical | ||||
Sequence: AGLVGFFLGVLAASLTLLLIG | ||||||
Topological domain | 689-777 | Cytoplasmic | ||||
Sequence: RRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPSPEDERLPLALGKRGSGFGGFPPPFLLDSCPSPAHIRLTGAPLATCDETSI |
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 490 | in strain: BALB/c | ||||
Sequence: T → P | ||||||
Natural variant | 659 | in strain: BALB/c | ||||
Sequence: A → S | ||||||
Mutagenesis | 775-777 | Loss of interaction with DLG4. | ||||
Sequence: Missing |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 35 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-40 | |||||
Sequence: MLARAERPRPGPRPPPVSLFPPPSSLLLLLLAMLSAPVCG | ||||||
Chain | PRO_0000032331 | 41-777 | Semaphorin-4F | |||
Sequence: RVPRSVPRTSLPISEADSYLTRFAAPHTYNYSALLVDPASHTLYVGARDSIFALTLPFSGEKPRRIDWMVPETHRQNCRKKGKKEDECHNFIQILAIANASHLLTCGTFAFDPKCGVIDVSSFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYTATVKNFLGTEPIISRAVGRAEDWIRTETLSSWLNAPAFVAAMVLSPAEWGDEDGDDEIFFFFTETSRVLDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASGVLQDMTELRPQPGAGTPLFYGIFSSQWEGAAISAVCAFRPQDIRAVLNGPFRELKHDCNRGLPVMDNEVPQPRPGECITNNMKFQQFGSSLSLPDRVLTFIRDHPLMDRPVFPADGRPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPETQPVESMKLYHDWLLVGSHTEVTQVNTSNCGRLQSCSECILAQDPVCAWSFRLDACVAHAGEHRGMVQDIESADVSSLCPKEPGEHPVVFEVPVATVGHVVLPCSPSSAWASCVWHQPSGVTSLTPRRDGLEVVVTPGAMGAYACECQEGGAARVVAAYSLVWGSQRGPANRAHTVVGAGLVGFFLGVLAASLTLLLIGRRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPSPEDERLPLALGKRGSGFGGFPPPFLLDSCPSPAHIRLTGAPLATCDETSI | ||||||
Glycosylation | 70 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 118↔128 | |||||
Sequence: CRKKGKKEDEC | ||||||
Glycosylation | 139 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 146↔155 | |||||
Sequence: CGTFAFDPKC | ||||||
Disulfide bond | 279↔390 | |||||
Sequence: CAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASGVLQDMTELRPQPGAGTPLFYGIFSSQWEGAAISAVCAFRPQDIRAVLNGPFRELKHDCNRGLPVMDNEVPQPRPGEC | ||||||
Disulfide bond | 303↔349 | |||||
Sequence: CPGPEHGRASGVLQDMTELRPQPGAGTPLFYGIFSSQWEGAAISAVC | ||||||
Glycosylation | 515 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 519↔536 | |||||
Sequence: CGRLQSCSECILAQDPVC | ||||||
Disulfide bond | 528↔545 | |||||
Sequence: CILAQDPVCAWSFRLDAC | ||||||
Disulfide bond | 593↔634 | |||||
Sequence: CSPSSAWASCVWHQPSGVTSLTPRRDGLEVVVTPGAMGAYAC | ||||||
Modified residue | 725 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 727 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed throughout the adult brain, where it shows particularly strong expression in the hippocampus, corpus callosum, granular layer and deep nuclei of the cerebellum, and the mitral layer of the olfactory bulb (at protein level) (PubMed:21945643).
At the cellular level, detected in neuronal precursors, postmitotic neurons, pyramidal neurons, and glial cells including mature oligodendocytes and oligodendroglial precursor cells (at protein level) (PubMed:21945643).
At the cellular level, detected in neuronal precursors, postmitotic neurons, pyramidal neurons, and glial cells including mature oligodendocytes and oligodendroglial precursor cells (at protein level) (PubMed:21945643).
Developmental stage
During 14 dpc expression is abundant in the cerebral cortex, hippocampus, brain stem and the mitral and glomerular layers of the olfactory bulb, expression in the olfactory bulb remains evident into adulthood (at protein level) (PubMed:21945643).
Expressed in proliferative layers and oligodendroglial precursor cells (OPCs) during embryonic development (14-16 dpc), in regions such as the ganglionic eminence, mamillothalamic tract, neuroepithelium, and cortical plate (at protein level) (PubMed:21945643).
Expressed in migrating OPCs along the optic nerve at 16.5 dpc (at protein level) (PubMed:21945643).
During late embryonic development (18 dpc) expression is abundant in pyramidal and granular cells of the hippocampus, and OPCs in the migratory pathway and embryonic fimbria of the hippocampus (at protein level) (PubMed:21945643).
At postnatal day 1 (P1) expression is abundant in the corpus callosum, anterior commissure, and several nerve nuclei in the hindbrain, such as the oculomotor nucleus, the periaqueductal gray area, the facial nucleus, the colliculli, and the raphe and pararubral nuclei, as well as in the proliferative layers of the anterior subventricular zone, with expression remaining evident into adulthood (at protein level) (PubMed:21945643).
A significant abundance of protein is apparent in the arcuate and posterior hypothalamic nuclei at P10, and additionally in hypothalamic OPCs, expression becomes evident in the arcuate nucleus at P15 (at protein level) (PubMed:21945643).
Abundant expression throughout the embryonic brain from 14 dpc onwards with decreased expression in all areas of the brain in adulthood, however expression remains relatively abundant (PubMed:21945643).
Expressed in proliferative layers and oligodendroglial precursor cells (OPCs) during embryonic development (14-16 dpc), in regions such as the ganglionic eminence, mamillothalamic tract, neuroepithelium, and cortical plate (at protein level) (PubMed:21945643).
Expressed in migrating OPCs along the optic nerve at 16.5 dpc (at protein level) (PubMed:21945643).
During late embryonic development (18 dpc) expression is abundant in pyramidal and granular cells of the hippocampus, and OPCs in the migratory pathway and embryonic fimbria of the hippocampus (at protein level) (PubMed:21945643).
At postnatal day 1 (P1) expression is abundant in the corpus callosum, anterior commissure, and several nerve nuclei in the hindbrain, such as the oculomotor nucleus, the periaqueductal gray area, the facial nucleus, the colliculli, and the raphe and pararubral nuclei, as well as in the proliferative layers of the anterior subventricular zone, with expression remaining evident into adulthood (at protein level) (PubMed:21945643).
A significant abundance of protein is apparent in the arcuate and posterior hypothalamic nuclei at P10, and additionally in hypothalamic OPCs, expression becomes evident in the arcuate nucleus at P15 (at protein level) (PubMed:21945643).
Abundant expression throughout the embryonic brain from 14 dpc onwards with decreased expression in all areas of the brain in adulthood, however expression remains relatively abundant (PubMed:21945643).
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 48-516 | Sema | ||||
Sequence: RTSLPISEADSYLTRFAAPHTYNYSALLVDPASHTLYVGARDSIFALTLPFSGEKPRRIDWMVPETHRQNCRKKGKKEDECHNFIQILAIANASHLLTCGTFAFDPKCGVIDVSSFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYTATVKNFLGTEPIISRAVGRAEDWIRTETLSSWLNAPAFVAAMVLSPAEWGDEDGDDEIFFFFTETSRVLDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASGVLQDMTELRPQPGAGTPLFYGIFSSQWEGAAISAVCAFRPQDIRAVLNGPFRELKHDCNRGLPVMDNEVPQPRPGECITNNMKFQQFGSSLSLPDRVLTFIRDHPLMDRPVFPADGRPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPETQPVESMKLYHDWLLVGSHTEVTQVNT | ||||||
Domain | 518-569 | PSI | ||||
Sequence: NCGRLQSCSECILAQDPVCAWSFRLDACVAHAGEHRGMVQDIESADVSSLCP | ||||||
Domain | 586-641 | Ig-like C2-type | ||||
Sequence: VGHVVLPCSPSSAWASCVWHQPSGVTSLTPRRDGLEVVVTPGAMGAYACECQEGGA | ||||||
Region | 703-742 | Disordered | ||||
Sequence: DKVGLDLGAPPSGTTSYSQDPPSPSPEDERLPLALGKRGS | ||||||
Motif | 775-777 | PDZ-binding | ||||
Sequence: TSI |
Sequence similarities
Belongs to the semaphorin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length777
- Mass (Da)84,490
- Last updated2011-07-27 v2
- Checksum3338F4F0AEFBF0DA
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0N4SUN0 | A0A0N4SUN0_MOUSE | Sema4f | 29 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB021291 EMBL· GenBank· DDBJ | BAA75630.1 EMBL· GenBank· DDBJ | mRNA | ||
AB022316 EMBL· GenBank· DDBJ | BAA75634.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH466523 EMBL· GenBank· DDBJ | EDK99043.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC094567 EMBL· GenBank· DDBJ | AAH94567.1 EMBL· GenBank· DDBJ | mRNA |