Q9Z103 · ADNP_MOUSE
- ProteinActivity-dependent neuroprotector homeobox protein
- GeneAdnp
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1108 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be involved in transcriptional regulation (PubMed:23071114, PubMed:32533114).
May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1 (PubMed:32533114).
May be required for neural induction and neuronal differentiation (PubMed:32533114).
May be involved in erythroid differentiation (PubMed:23071114).
May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1 (PubMed:32533114).
May be required for neural induction and neuronal differentiation (PubMed:32533114).
May be involved in erythroid differentiation (PubMed:23071114).
Miscellaneous
When isolated from the sequence, the neuroprotective peptide provides neuroprotection at subfemtomolar concentrations against toxicity associated with tetrodoxin (electrical blockade), the amyloid-beta peptide (the Alzheimer disease neurotoxin), N-methyl-aspartate (excitotoxicity), and the human immunideficiency virus (HIV) envelope protein.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 753-813 | Homeobox | ||||
Sequence: LDPKGHEDDSYEARKSFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKCVRD |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameActivity-dependent neuroprotector homeobox protein
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9Z103
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, cross-link, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000048808 | 1-1108 | Activity-dependent neuroprotector homeobox protein | |||
Sequence: MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACPFSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTFNADKKTLETHIKIFHAPNSSAPSSSLSTFKDKNKNDGLKPKQADNVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVSLGTNAREECNIHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRAKPLMLIAPKPQDKKGMGLPPRISSLASGNVRSLPSQQMVNRLSIPKPNLNSTGVNMMSNVHLQQNNYGVKSVGQSYGVGQSVRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSFGLGAEQRPPAAARYSLQTANTSLPPGQVKSPSVSQSQASRVLGQSSSKPPPAATGPPPSNHCATQKWKICTICNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLIHGLSCPYCRSTFNDVEKMAAHMRMVHIDEEMGPKTDSTLSFDLTLQQGSHTNIHLLVTTYNLRDAPAESVAYHAQNNAPVPPKPQPKVQEKADVPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKTNAPSRLNQSPGLAPVKRTYEQMEFPLLKKRKLEEDADSPSCFEEKPEEPVVLALDPKGHEDDSYEARKSFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKCVRDCEKYKPGVLLGFNMKELNKVKHEMDFDAEWLFENHDEKDSRVNASKTVDKKHNLGKEDDSFSDSFEHLEEESNGSGSPFDPVFEVEPKIPSDNLEEPVPKVIPEGALESEKLDQKEEEEEEEEEDGSKYETIHLTEEPAKLMHDASDSEVDQDDVVEWKDGASPSESGPGSQQISDFEDNTCEMKPGTWSDESSQSEDARSSKPAAKKKATVQDDTEQLKWKNSSYGKVEGFWSKDQSQWENASENAERLPNPQIEWQNSTIDSEDGEQFDSMTDGVADPMHGSLTGVKLSSQQA | ||||||
Cross-link | 39 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 72 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Modified residue | 98 | Phosphoserine | ||||
Sequence: S | ||||||
Cross-link | 144 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 155 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 203 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 231 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 266 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 274 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 278 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 279 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 311 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 335 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Modified residue | 348 | Asymmetric dimethylarginine | ||||
Sequence: R | ||||||
Cross-link | 367 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 407 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Modified residue | 408 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 412 | Phosphoserine | ||||
Sequence: S | ||||||
Cross-link | 426 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 599 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 605 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Modified residue | 607 | Phosphoserine | ||||
Sequence: S | ||||||
Cross-link | 615 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 620 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 631 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 657 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 698 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Modified residue | 708 | Phosphoserine | ||||
Sequence: S | ||||||
Cross-link | 715 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 727 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 730 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Modified residue | 737 | Phosphoserine | ||||
Sequence: S | ||||||
Cross-link | 744 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Modified residue | 804 | Phosphoserine | ||||
Sequence: S | ||||||
Cross-link | 806 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 828 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 834 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Modified residue | 875 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 877 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 885 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 888 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 904 | Phosphoserine | ||||
Sequence: S | ||||||
Cross-link | 913 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 928 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 941 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Modified residue | 959 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 961 | Phosphoserine | ||||
Sequence: S | ||||||
Cross-link | 1022 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Modified residue | 1041 | N6-acetyllysine; alternate | ||||
Sequence: K | ||||||
Cross-link | 1041 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate | ||||
Sequence: K | ||||||
Modified residue | 1048 | N6-acetyllysine; alternate | ||||
Sequence: K | ||||||
Cross-link | 1048 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate | ||||
Sequence: K | ||||||
Modified residue | 1077 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the brain, with a higher expression in cerebellum and hippocampus. Weakly expressed in lung, kidney and intestine, and expressed at intermediate level in testis.
Induction
By the neuroprotective peptide VIP.
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for region, zinc finger, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-685 | Binds to beta-catenin/CTNNB1 | ||||
Sequence: MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACPFSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTFNADKKTLETHIKIFHAPNSSAPSSSLSTFKDKNKNDGLKPKQADNVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVSLGTNAREECNIHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRAKPLMLIAPKPQDKKGMGLPPRISSLASGNVRSLPSQQMVNRLSIPKPNLNSTGVNMMSNVHLQQNNYGVKSVGQSYGVGQSVRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSFGLGAEQRPPAAARYSLQTANTSLPPGQVKSPSVSQSQASRVLGQSSSKPPPAATGPPPSNHCATQKWKICTICNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLIHGLSCPYCRSTFNDVEKMAAHMRMVHIDEEMGPKTDSTLSFDLTLQQGSHTNIHLLVTTYNLRDAPAESVAYHAQNNAPVPPKPQPKVQEKADVPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVH | ||||||
Zinc finger | 74-97 | C2H2-type 1; degenerate | ||||
Sequence: FCCSACPFSSKFFSAYKSHFRNVH | ||||||
Zinc finger | 107-129 | C2H2-type 2; degenerate | ||||
Sequence: LNCPYCTFNADKKTLETHIKIFH | ||||||
Region | 133-154 | Disordered | ||||
Sequence: SSAPSSSLSTFKDKNKNDGLKP | ||||||
Zinc finger | 165-188 | C2H2-type 3; degenerate | ||||
Sequence: YYCKKCTYRDPLYEIVRKHIYREH | ||||||
Zinc finger | 221-244 | C2H2-type 4; degenerate | ||||
Sequence: IHCKRCLFMPKSYEALVQHVIEDH | ||||||
Region | 354-361 | Neuroprotective peptide; contributes to CTNNB1-binding, but less effective than whole N-terminal region | ||||
Sequence: NAPVSIPQ | ||||||
Region | 360-438 | Disordered | ||||
Sequence: PQQSQSVKQLLPSGNGRSFGLGAEQRPPAAARYSLQTANTSLPPGQVKSPSVSQSQASRVLGQSSSKPPPAATGPPPSN | ||||||
Compositional bias | 391-427 | Polar residues | ||||
Sequence: RYSLQTANTSLPPGQVKSPSVSQSQASRVLGQSSSKP | ||||||
Zinc finger | 446-468 | C2H2-type 5; atypical | ||||
Sequence: KICTICNELFPENVYSVHFEKEH | ||||||
Zinc finger | 488-509 | C2H2-type 6 | ||||
Sequence: SKCLYCNRYLPTDTLLNHMLIH | ||||||
Zinc finger | 511-534 | C2H2-type 7 | ||||
Sequence: LSCPYCRSTFNDVEKMAAHMRMVH | ||||||
Zinc finger | 621-646 | C2H2-type 8; atypical | ||||
Sequence: TLCPLCFSILKGPISDALAHHLRERH | ||||||
Zinc finger | 661-685 | C2H2-type 9; atypical | ||||
Sequence: YKCIHCLGVYTSNMTASTITLHLVH | ||||||
Region | 690-711 | Disordered | ||||
Sequence: GKTQNGQDKTNAPSRLNQSPGL | ||||||
Compositional bias | 692-707 | Polar residues | ||||
Sequence: TQNGQDKTNAPSRLNQ | ||||||
Compositional bias | 851-883 | Basic and acidic residues | ||||
Sequence: KDSRVNASKTVDKKHNLGKEDDSFSDSFEHLEE | ||||||
Region | 851-1037 | Disordered | ||||
Sequence: KDSRVNASKTVDKKHNLGKEDDSFSDSFEHLEEESNGSGSPFDPVFEVEPKIPSDNLEEPVPKVIPEGALESEKLDQKEEEEEEEEEDGSKYETIHLTEEPAKLMHDASDSEVDQDDVVEWKDGASPSESGPGSQQISDFEDNTCEMKPGTWSDESSQSEDARSSKPAAKKKATVQDDTEQLKWKNS | ||||||
Compositional bias | 940-962 | Basic and acidic residues | ||||
Sequence: SKYETIHLTEEPAKLMHDASDSE | ||||||
Compositional bias | 978-992 | Polar residues | ||||
Sequence: SESGPGSQQISDFED | ||||||
Compositional bias | 1009-1029 | Basic and acidic residues | ||||
Sequence: SEDARSSKPAAKKKATVQDDT | ||||||
Compositional bias | 1050-1080 | Polar residues | ||||
Sequence: QSQWENASENAERLPNPQIEWQNSTIDSEDG | ||||||
Region | 1050-1108 | Disordered | ||||
Sequence: QSQWENASENAERLPNPQIEWQNSTIDSEDGEQFDSMTDGVADPMHGSLTGVKLSSQQA |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,108
- Mass (Da)124,308
- Last updated2015-10-14 v2
- ChecksumC69498C5DFC9150B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 391-427 | Polar residues | ||||
Sequence: RYSLQTANTSLPPGQVKSPSVSQSQASRVLGQSSSKP | ||||||
Compositional bias | 692-707 | Polar residues | ||||
Sequence: TQNGQDKTNAPSRLNQ | ||||||
Compositional bias | 851-883 | Basic and acidic residues | ||||
Sequence: KDSRVNASKTVDKKHNLGKEDDSFSDSFEHLEE | ||||||
Compositional bias | 940-962 | Basic and acidic residues | ||||
Sequence: SKYETIHLTEEPAKLMHDASDSE | ||||||
Compositional bias | 978-992 | Polar residues | ||||
Sequence: SESGPGSQQISDFED | ||||||
Compositional bias | 1009-1029 | Basic and acidic residues | ||||
Sequence: SEDARSSKPAAKKKATVQDDT | ||||||
Compositional bias | 1050-1080 | Polar residues | ||||
Sequence: QSQWENASENAERLPNPQIEWQNSTIDSEDG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX005039 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AF068198 EMBL· GenBank· DDBJ | AAD19843.1 EMBL· GenBank· DDBJ | mRNA |