Q9Z0G2 · SRPK3_MOUSE
- ProteinSRSF protein kinase 3
- GeneSrpk3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids565 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | cell differentiation | |
Biological Process | intracellular signal transduction | |
Biological Process | muscle tissue development | |
Biological Process | regulation of mRNA processing | |
Biological Process | skeletal muscle tissue development | |
Biological Process | spliceosomal complex assembly |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSRSF protein kinase 3
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9Z0G2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Disruption phenotype
Mice are viable to adulthood but display defects in skeletal muscle growth including reduced muscle mass, marked increase in centrally placed nuclei and disorganized intermyofibrillar network.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 26 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000086710 | 1-565 | SRSF protein kinase 3 | |||
Sequence: MSANAGGSGSVDCGGSSSSSQTSCGPESSGSELTPATPAPRLLQGLLGSDDEEQEDPKDYCKGGYYPVKIGDLFNGRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIRRLAAEATEWQQSGAQPPSRSTVSTAPQEVLIGKLSKNKRKKMRRKRKQQKRLLEERLRDLQRLEAMEAAVQAEDSSSRLERGSGSTSSSGCHPEGTRAGPSPASSSPVPGGERSLSPSSQTSGFSGSLFSTASCSILSGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIPNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWLNP | ||||||
Modified residue | 49 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 328 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Exclusively expressed in skeletal and heart muscle.
Developmental stage
Expressed from embryogenesis to adulthood.
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-35 | Polar residues | ||||
Sequence: MSANAGGSGSVDCGGSSSSSQTSCGPESSGSELTP | ||||||
Region | 1-44 | Disordered | ||||
Sequence: MSANAGGSGSVDCGGSSSSSQTSCGPESSGSELTPATPAPRLLQ | ||||||
Domain | 78-563 | Protein kinase | ||||
Sequence: YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIRRLAAEATEWQQSGAQPPSRSTVSTAPQEVLIGKLSKNKRKKMRRKRKQQKRLLEERLRDLQRLEAMEAAVQAEDSSSRLERGSGSTSSSGCHPEGTRAGPSPASSSPVPGGERSLSPSSQTSGFSGSLFSTASCSILSGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIPNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWL | ||||||
Compositional bias | 236-257 | Polar residues | ||||
Sequence: WQQSGAQPPSRSTVSTAPQEVL | ||||||
Region | 236-280 | Disordered | ||||
Sequence: WQQSGAQPPSRSTVSTAPQEVLIGKLSKNKRKKMRRKRKQQKRLL | ||||||
Compositional bias | 263-278 | Basic residues | ||||
Sequence: KNKRKKMRRKRKQQKR | ||||||
Region | 295-350 | Disordered | ||||
Sequence: AAVQAEDSSSRLERGSGSTSSSGCHPEGTRAGPSPASSSPVPGGERSLSPSSQTSG | ||||||
Compositional bias | 303-350 | Polar residues | ||||
Sequence: SSRLERGSGSTSSSGCHPEGTRAGPSPASSSPVPGGERSLSPSSQTSG |
Sequence similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length565
- Mass (Da)62,365
- Last updated1999-05-01 v1
- Checksum34976D08141C5DC8
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-35 | Polar residues | ||||
Sequence: MSANAGGSGSVDCGGSSSSSQTSCGPESSGSELTP | ||||||
Compositional bias | 236-257 | Polar residues | ||||
Sequence: WQQSGAQPPSRSTVSTAPQEVL | ||||||
Compositional bias | 263-278 | Basic residues | ||||
Sequence: KNKRKKMRRKRKQQKR | ||||||
Compositional bias | 303-350 | Polar residues | ||||
Sequence: SSRLERGSGSTSSSGCHPEGTRAGPSPASSSPVPGGERSLSPSSQTSG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF043289 EMBL· GenBank· DDBJ | AAD02248.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF043288 EMBL· GenBank· DDBJ | AAD02247.1 EMBL· GenBank· DDBJ | mRNA | ||
AF133093 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |