Q9Z0D2 · CLINK_MDV1
- ProteinCell cycle link protein
- GeneDNA-C
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids169 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Interacts with and disrupts the function of host retinoblastoma-related proteins RBR, which are key regulators of the cell cycle. Induces transcriptional activation of E2F-regulated S-phase and G2/M-phase-specific genes. Inactivation of the ability of RBR to arrest the cell cycle leads to the stimulation of viral DNA replication (By similarity).
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameCell cycle link protein
- Short namesClink
Gene names
Organism names
- Taxonomic lineageViruses > Monodnaviria > Shotokuvirae > Cressdnaviricota > Arfiviricetes > Mulpavirales > Nanoviridae > Nanovirus > Milk vetch dwarf virus
- Virus hosts
Accessions
- Primary accessionQ9Z0D2
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000338626 | 1-169 | Cell cycle link protein | ||
Interaction
Subunit
Interacts with host SKP1. Interacts (via LXCXE domain) with host retinoblastoma-related protein 1 (RBR1). Interacts (via LXCXE domain) with retinoblastoma-related proteins (RBR) (By similarity).
Family & Domains
Features
Showing features for region, motif.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 9-22 | Binding to host SKP1 protein | |||
Motif | 110-114 | LXCXE motif, interaction with host RBR | |||
Sequence similarities
Belongs to the nanovirus Clink protein family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length169
- Mass (Da)19,691
- Last updated1999-05-01 v1
- ChecksumE452505C8ACD3863
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB000923 EMBL· GenBank· DDBJ | BAA33983.1 EMBL· GenBank· DDBJ | Genomic DNA |