Q9Z0D2 · CLINK_MDV1

Function

function

Interacts with and disrupts the function of host retinoblastoma-related proteins RBR, which are key regulators of the cell cycle. Induces transcriptional activation of E2F-regulated S-phase and G2/M-phase-specific genes. Inactivation of the ability of RBR to arrest the cell cycle leads to the stimulation of viral DNA replication (By similarity).

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cell cycle link protein
  • Short names
    Clink

Gene names

    • Name
      DNA-C
    • Synonyms
      C4

Organism names

Accessions

  • Primary accession
    Q9Z0D2

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003386261-169Cell cycle link protein

Interaction

Subunit

Interacts with host SKP1. Interacts (via LXCXE domain) with host retinoblastoma-related protein 1 (RBR1). Interacts (via LXCXE domain) with retinoblastoma-related proteins (RBR) (By similarity).

Structure

3D structure databases

Family & Domains

Features

Showing features for region, motif.

Type
IDPosition(s)Description
Region9-22Binding to host SKP1 protein
Motif110-114LXCXE motif, interaction with host RBR

Sequence similarities

Belongs to the nanovirus Clink protein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    169
  • Mass (Da)
    19,691
  • Last updated
    1999-05-01 v1
  • Checksum
    E452505C8ACD3863
MGLKYFAHLPLELREKIVRDHLQEERKKEFLEKAIEDSCRRHEALLIEDPSPAELNSLSKFLTALSDYVGNQFNTRCLIRWKKDVPSKVKFGFMDEQHHKLYGSMDMDDLSCGELFIPDEEDDLTYEDGVIVRCSQLDQLFKSLGIEIVYIVVSKHCIWAPLSKEIVIK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB000923
EMBL· GenBank· DDBJ
BAA33983.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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