Q9YHE8 · T7L1A_DANRE
- ProteinTranscription factor 7-like 1-A
- Genetcf7l1a
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids560 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Required early in development for dorsal specific gene activation and during gastrulation for repression of dorsal-specific genes in the marginal zone. Required for head formation and forebrain specification. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 329-397 | HMG box | ||||
Sequence: IKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWS |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTranscription factor 7-like 1-A
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ9YHE8
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000048621 | 1-560 | Transcription factor 7-like 1-A | |||
Sequence: MPQLNGGGGDDLGANDELISFKDEGEQEEKISENVSSERDLDEVKSSLVNESENNSSSSDSEQTDRRPRPRPDLESYEKQREYFAEALRRQQDGGFFKGPPYAGYPFLMIPDITNPYLSNGSLSPSTRTYLQMKWPLLDVPASAALKDSRSPTPGHLSNKVPVVQHPHHVHPLTPLITYSNEHFSPGTPPSHLSPEILDPKTGIPRTPHPSELSPYYPLSPGAVGQIPHPLGWLVPQQGQHMYSIPPGGFRHPYPALAMNASMSSLVSSRFSPHMVPHPPHGLHQTGIPHPAIVSPAIKQEPNGESPSNSTHGKPSVPVKKEEEKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNYGKRKKRKRDCKSDSPSESNFSPQPKKQCVPYLSSEKMCDSPTSSHGSMLDSPATPSAALASPAAPAATHSEQAQPLSLTTKPEGRAHHNHPHFPLPGKSSGSGSGSSMALHSLSRPIPFTSLPPSLLGPNSPFHQAALHSHHALLQTQPLSLVTKSVE |
Proteomic databases
Expression
Induction
By ctnnb1.
Developmental stage
Expressed maternally and throughout embryogenesis. Expressed in the dorsal mesoderm at 6 hours post fertilization (6 hpf), and this expression is maintained in the axial mesoderm during gastrulation and early somitogenesis. Strongly expressed in the prospective neuroectoderm at 8 hpf. Expression persists in the neuroectoderm and increases in the tail bud at the end of gastrulation, at 10 hpf. Enriched in the prechordal mesoderm and developing notochord and in ventromedial regions of the brain and neural tube during the early somite stages. Expression remains elevated within the tail bud, forebrain, the midbrain-hindbrain boundary and in the developing otic vesicles as somitogenesis progresses.
Gene expression databases
Interaction
Subunit
Interacts with tle3a/gro2.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
XENO | Q9YHE8 | E4F1 Q66K89 | 2 | EBI-6979298, EBI-1227043 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-77 | Disordered | ||||
Sequence: MPQLNGGGGDDLGANDELISFKDEGEQEEKISENVSSERDLDEVKSSLVNESENNSSSSDSEQTDRRPRPRPDLESY | ||||||
Compositional bias | 16-47 | Basic and acidic residues | ||||
Sequence: DELISFKDEGEQEEKISENVSSERDLDEVKSS | ||||||
Compositional bias | 60-77 | Basic and acidic residues | ||||
Sequence: DSEQTDRRPRPRPDLESY | ||||||
Region | 297-328 | Disordered | ||||
Sequence: AIKQEPNGESPSNSTHGKPSVPVKKEEEKKPH | ||||||
Compositional bias | 301-315 | Polar residues | ||||
Sequence: EPNGESPSNSTHGKP | ||||||
Region | 395-513 | Disordered | ||||
Sequence: GWSARDNYGKRKKRKRDCKSDSPSESNFSPQPKKQCVPYLSSEKMCDSPTSSHGSMLDSPATPSAALASPAAPAATHSEQAQPLSLTTKPEGRAHHNHPHFPLPGKSSGSGSGSSMALH | ||||||
Compositional bias | 438-453 | Polar residues | ||||
Sequence: KMCDSPTSSHGSMLDS |
Sequence similarities
Belongs to the TCF/LEF family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length560
- Mass (Da)61,459
- Last updated1999-05-01 v1
- ChecksumDC35C50EA4D61232
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 16-47 | Basic and acidic residues | ||||
Sequence: DELISFKDEGEQEEKISENVSSERDLDEVKSS | ||||||
Compositional bias | 60-77 | Basic and acidic residues | ||||
Sequence: DSEQTDRRPRPRPDLESY | ||||||
Compositional bias | 301-315 | Polar residues | ||||
Sequence: EPNGESPSNSTHGKP | ||||||
Compositional bias | 438-453 | Polar residues | ||||
Sequence: KMCDSPTSSHGSMLDS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF097410 EMBL· GenBank· DDBJ | AAC64609.1 EMBL· GenBank· DDBJ | mRNA | ||
BC053135 EMBL· GenBank· DDBJ | AAH53135.1 EMBL· GenBank· DDBJ | mRNA |