Q9YH05 · OPSD_DIPAN
- ProteinRhodopsin
- Generho
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids353 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity).
Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 113 | Plays an important role in the conformation switch to the active conformation | ||||
Sequence: E |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | photoreceptor disc membrane | |
Cellular Component | plasma membrane | |
Molecular Function | 11-cis retinal binding | |
Molecular Function | G protein-coupled photoreceptor activity | |
Biological Process | absorption of visible light | |
Biological Process | G protein-coupled opsin signaling pathway | |
Biological Process | visual perception |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameRhodopsin
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Spariformes > Sparidae > Diplodus
Accessions
- Primary accessionQ9YH05
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Note: Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-36 | Extracellular | ||||
Sequence: MNGTEGPFFYVPMVNTTGIVRSPYEYPQYYLVNPAA | ||||||
Transmembrane | 37-61 | Helical; Name=1 | ||||
Sequence: YAALGAYMFLLILVGFPINFLTLYV | ||||||
Topological domain | 62-73 | Cytoplasmic | ||||
Sequence: TIEHKKLRTPLN | ||||||
Transmembrane | 74-96 | Helical; Name=2 | ||||
Sequence: YILLNLAVADLFMVLGGFTTTMY | ||||||
Topological domain | 97-110 | Extracellular | ||||
Sequence: TSMHGYFVLGRLGC | ||||||
Transmembrane | 111-133 | Helical; Name=3 | ||||
Sequence: NIEGFFATLGGEIALWSLVVLAI | ||||||
Topological domain | 134-152 | Cytoplasmic | ||||
Sequence: ERWVVVCKPISNFRFGENH | ||||||
Transmembrane | 153-173 | Helical; Name=4 | ||||
Sequence: AIMGLAFTWTMAMACAAPPLV | ||||||
Topological domain | 174-202 | Extracellular | ||||
Sequence: GWSRYIPEGMQCSCGIDYYTRAEGFNNES | ||||||
Transmembrane | 203-224 | Helical; Name=5 | ||||
Sequence: FVIYMFICHFTIPLTVVFFCYG | ||||||
Topological domain | 225-252 | Cytoplasmic | ||||
Sequence: RLLCAVKEAAAAQQESETTQRAEKEVTR | ||||||
Transmembrane | 253-274 | Helical; Name=6 | ||||
Sequence: MVIMMVIAFLVCWLPYASVAWY | ||||||
Topological domain | 275-286 | Extracellular | ||||
Sequence: IFTHQGSEFGPV | ||||||
Transmembrane | 287-308 | Helical; Name=7 | ||||
Sequence: FMTIPAFFAKSSSIYNPMIYIC | ||||||
Topological domain | 309-353 | Cytoplasmic | ||||
Sequence: LNKQFRHCMITTLCCGKNPFEEEEGASTASKTEASSVSSSSVSPA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, modified residue, lipidation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000197671 | 1-353 | Rhodopsin | |||
Sequence: MNGTEGPFFYVPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVLGGFTTTMYTSMHGYFVLGRLGCNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGLAFTWTMAMACAAPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFICHFTIPLTVVFFCYGRLLCAVKEAAAAQQESETTQRAEKEVTRMVIMMVIAFLVCWLPYASVAWYIFTHQGSEFGPVFMTIPAFFAKSSSIYNPMIYICLNKQFRHCMITTLCCGKNPFEEEEGASTASKTEASSVSSSSVSPA | ||||||
Glycosylation | 2 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 15 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 110↔187 | |||||
Sequence: CNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGLAFTWTMAMACAAPPLVGWSRYIPEGMQCSC | ||||||
Glycosylation | 200 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Modified residue | 296 | N6-(retinylidene)lysine | ||||
Sequence: K | ||||||
Lipidation | 322 | S-palmitoyl cysteine | ||||
Sequence: C | ||||||
Lipidation | 323 | S-palmitoyl cysteine | ||||
Sequence: C |
Post-translational modification
Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
Contains one covalently linked retinal chromophore.
Keywords
- PTM
PTM databases
Structure
Family & Domains
Features
Showing features for motif, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 134-136 | 'Ionic lock' involved in activated form stabilization | ||||
Sequence: ERW | ||||||
Region | 331-353 | Disordered | ||||
Sequence: EEGASTASKTEASSVSSSSVSPA | ||||||
Compositional bias | 337-353 | Polar residues | ||||
Sequence: ASKTEASSVSSSSVSPA |
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
Keywords
- Domain
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length353
- Mass (Da)39,470
- Last updated1999-05-01 v1
- Checksum5F3E848D2FB30817
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 337-353 | Polar residues | ||||
Sequence: ASKTEASSVSSSSVSPA |