Q9YH05 · OPSD_DIPAN

Function

function

Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity).
Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).

Features

Showing features for site.

135350100150200250300350
TypeIDPosition(s)Description
Site113Plays an important role in the conformation switch to the active conformation

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentphotoreceptor disc membrane
Cellular Componentplasma membrane
Molecular Function11-cis retinal binding
Molecular FunctionG protein-coupled photoreceptor activity
Biological Processabsorption of visible light
Biological ProcessG protein-coupled opsin signaling pathway
Biological Processvisual perception

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Rhodopsin

Gene names

    • Name
      rho

Organism names

Accessions

  • Primary accession
    Q9YH05

Subcellular Location

Membrane
; Multi-pass membrane protein
Note: Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-36Extracellular
Transmembrane37-61Helical; Name=1
Topological domain62-73Cytoplasmic
Transmembrane74-96Helical; Name=2
Topological domain97-110Extracellular
Transmembrane111-133Helical; Name=3
Topological domain134-152Cytoplasmic
Transmembrane153-173Helical; Name=4
Topological domain174-202Extracellular
Transmembrane203-224Helical; Name=5
Topological domain225-252Cytoplasmic
Transmembrane253-274Helical; Name=6
Topological domain275-286Extracellular
Transmembrane287-308Helical; Name=7
Topological domain309-353Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond, modified residue, lipidation.

TypeIDPosition(s)Description
ChainPRO_00001976711-353Rhodopsin
Glycosylation2N-linked (GlcNAc...) asparagine
Glycosylation15N-linked (GlcNAc...) asparagine
Disulfide bond110↔187
Glycosylation200N-linked (GlcNAc...) asparagine
Modified residue296N6-(retinylidene)lysine
Lipidation322S-palmitoyl cysteine
Lipidation323S-palmitoyl cysteine

Post-translational modification

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
Contains one covalently linked retinal chromophore.

Keywords

PTM databases

Structure

Family & Domains

Features

Showing features for motif, region, compositional bias.

TypeIDPosition(s)Description
Motif134-136'Ionic lock' involved in activated form stabilization
Region331-353Disordered
Compositional bias337-353Polar residues

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Keywords

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    353
  • Mass (Da)
    39,470
  • Last updated
    1999-05-01 v1
  • Checksum
    5F3E848D2FB30817
MNGTEGPFFYVPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVLGGFTTTMYTSMHGYFVLGRLGCNIEGFFATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGLAFTWTMAMACAAPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFICHFTIPLTVVFFCYGRLLCAVKEAAAAQQESETTQRAEKEVTRMVIMMVIAFLVCWLPYASVAWYIFTHQGSEFGPVFMTIPAFFAKSSSIYNPMIYICLNKQFRHCMITTLCCGKNPFEEEEGASTASKTEASSVSSSSVSPA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias337-353Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y18662
EMBL· GenBank· DDBJ
CAA77244.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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