Q9YBS3 · AIPS_AERPE
- ProteinArchaetidylinositol phosphate synthase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids194 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
Catalytic activity
- 1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol = CMP + H+ + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate
Cofactor
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )
Note: Binds 2 Mg2+ or Mn2+ ions per subunit.
Pathway
Lipid metabolism; phospholipid metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 67 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 67 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 70 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 88 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 88 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 92 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 92 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | magnesium ion binding | |
Molecular Function | phosphotransferase activity, for other substituted phosphate groups | |
Biological Process | phospholipid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameArchaetidylinositol phosphate synthase
- EC number
- Short namesAIP synthase
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Desulfurococcales > Desulfurococcaceae > Aeropyrum
Accessions
- Primary accessionQ9YBS3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 32-51 | Helical | ||||
Sequence: IYTLASPVAAAAALPAWLYI | ||||||
Transmembrane | 58-78 | Helical | ||||
Sequence: LLIALSLLLDAVDGAVARFTG | ||||||
Transmembrane | 103-123 | Helical | ||||
Sequence: LYIAGVHPLIVIAMLSGGLIV | ||||||
Transmembrane | 150-170 | Helical | ||||
Sequence: IAILAILAISIYNLQTALALA | ||||||
Transmembrane | 172-192 | Helical | ||||
Sequence: AAAVLVWITVIQRMVYIAGEL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000448366 | 1-194 | Archaetidylinositol phosphate synthase | |||
Sequence: MGVFNRLRSFYEARIAPTVASFLSRISPDPNIYTLASPVAAAAALPAWLYISPVASLLLIALSLLLDAVDGAVARFTGRVSPLGSFLDSSLDRISDSLYHATLYIAGVHPLIVIAMLSGGLIVPYLRAKGESLGLEVRGRGLMERGERSIAILAILAISIYNLQTALALASAAAVLVWITVIQRMVYIAGELRR |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length194
- Mass (Da)20,735
- Last updated2006-11-14 v2
- Checksum9C3651A4F3627E71
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BA000002 EMBL· GenBank· DDBJ | BAA80525.2 EMBL· GenBank· DDBJ | Genomic DNA |