Q9YBS3 · AIPS_AERPE

Function

function

Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 Mg2+ or Mn2+ ions per subunit.

Pathway

Lipid metabolism; phospholipid metabolism.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site67Mg2+ 1 (UniProtKB | ChEBI)
Binding site67Mg2+ 2 (UniProtKB | ChEBI)
Binding site70Mg2+ 1 (UniProtKB | ChEBI)
Binding site88Mg2+ 1 (UniProtKB | ChEBI)
Binding site88Mg2+ 2 (UniProtKB | ChEBI)
Active site92Proton acceptor
Binding site92Mg2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionmagnesium ion binding
Molecular Functionphosphotransferase activity, for other substituted phosphate groups
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Archaetidylinositol phosphate synthase
  • EC number
  • Short names
    AIP synthase

Gene names

    • Ordered locus names
      APE_1526.1

Organism names

Accessions

  • Primary accession
    Q9YBS3

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane32-51Helical
Transmembrane58-78Helical
Transmembrane103-123Helical
Transmembrane150-170Helical
Transmembrane172-192Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004483661-194Archaetidylinositol phosphate synthase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    194
  • Mass (Da)
    20,735
  • Last updated
    2006-11-14 v2
  • Checksum
    9C3651A4F3627E71
MGVFNRLRSFYEARIAPTVASFLSRISPDPNIYTLASPVAAAAALPAWLYISPVASLLLIALSLLLDAVDGAVARFTGRVSPLGSFLDSSLDRISDSLYHATLYIAGVHPLIVIAMLSGGLIVPYLRAKGESLGLEVRGRGLMERGERSIAILAILAISIYNLQTALALASAAAVLVWITVIQRMVYIAGELRR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000002
EMBL· GenBank· DDBJ
BAA80525.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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