Q9Y6W6 · DUS10_HUMAN
- ProteinDual specificity protein phosphatase 10
- GeneDUSP10
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids482 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.
Catalytic activity
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 408 | Phosphocysteine intermediate | ||||
Sequence: C |
GO annotations
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDual specificity protein phosphatase 10
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9Y6W6
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 180-181 | Reduced enzyme activity with MAPK14. | ||||
Sequence: FM → DD | ||||||
Mutagenesis | 203-204 | Strongly reduced affinity for MAPK14. Almost abolishes enzyme activity with MAPK14. | ||||
Sequence: RR → AA |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 506 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000094813 | 1-482 | Dual specificity protein phosphatase 10 | |||
Sequence: MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTYMPSSSGSARSLNCGCSSASCCTVATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNNNENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSLQLQECREVGGGASAASSLLPQPIPTTPDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGVETVV |
Proteomic databases
PTM databases
Interaction
Subunit
Monomer. Interacts with MAPK14.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9Y6W6 | ATN1 Q86V38 | 3 | EBI-3443946, EBI-11954292 | |
BINARY | Q9Y6W6 | BACE2 Q9Y5Z0 | 3 | EBI-3443946, EBI-11282723 | |
BINARY | Q9Y6W6 | CRYAA P02489 | 3 | EBI-3443946, EBI-6875961 | |
BINARY | Q9Y6W6 | DYNC1H1 Q14204 | 3 | EBI-3443946, EBI-356015 | |
BINARY | Q9Y6W6 | FGFR3 P22607 | 3 | EBI-3443946, EBI-348399 | |
BINARY | Q9Y6W6 | FNDC3B Q53EP0-3 | 3 | EBI-3443946, EBI-10242151 | |
BINARY | Q9Y6W6 | GRIN2C Q14957 | 3 | EBI-3443946, EBI-8285963 | |
BINARY | Q9Y6W6 | GSN P06396 | 3 | EBI-3443946, EBI-351506 | |
BINARY | Q9Y6W6 | HOXA1 P49639 | 5 | EBI-3443946, EBI-740785 | |
BINARY | Q9Y6W6 | HRAS P01112 | 3 | EBI-3443946, EBI-350145 | |
BINARY | Q9Y6W6 | KRTAP3-2 Q9BYR7 | 3 | EBI-3443946, EBI-751260 | |
BINARY | Q9Y6W6 | MAPK8 P45983-4 | 3 | EBI-3443946, EBI-18121963 | |
BINARY | Q9Y6W6 | MAPK9 P45984 | 5 | EBI-3443946, EBI-713568 | |
BINARY | Q9Y6W6 | UBQLN1 Q9UMX0 | 3 | EBI-3443946, EBI-741480 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 168-285 | Rhodanese | ||||
Sequence: PSQGPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCD | ||||||
Region | 199-215 | Interaction with MAP kinases | ||||
Sequence: KISRRRLQQGKITVLDL | ||||||
Domain | 321-464 | Tyrosine-protein phosphatase | ||||
Sequence: ELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNN |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9Y6W6-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length482
- Mass (Da)52,642
- Last updated1999-11-01 v1
- ChecksumA8CB74ABF9498CD4
Q9Y6W6-2
- Name2
- Differences from canonical
- 1-342: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0B4J2F5 | A0A0B4J2F5_HUMAN | DUSP10 | 66 |
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_036549 | 1-342 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB026436 EMBL· GenBank· DDBJ | BAA81668.1 EMBL· GenBank· DDBJ | mRNA | ||
AF179212 EMBL· GenBank· DDBJ | AAD51857.1 EMBL· GenBank· DDBJ | mRNA | ||
AK022513 EMBL· GenBank· DDBJ | BAB14070.1 EMBL· GenBank· DDBJ | mRNA | ||
AL590966 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471100 EMBL· GenBank· DDBJ | EAW93283.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471100 EMBL· GenBank· DDBJ | EAW93285.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471100 EMBL· GenBank· DDBJ | EAW93286.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471100 EMBL· GenBank· DDBJ | EAW93287.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC020608 EMBL· GenBank· DDBJ | AAH20608.1 EMBL· GenBank· DDBJ | mRNA | ||
BC031405 EMBL· GenBank· DDBJ | AAH31405.1 EMBL· GenBank· DDBJ | mRNA | ||
BC063826 EMBL· GenBank· DDBJ | AAH63826.1 EMBL· GenBank· DDBJ | mRNA |