Q9Y6G5 · COMDA_HUMAN

  • Protein
    COMM domain-containing protein 10
  • Gene
    COMMD10
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Variants

120220406080100120140160180200
GAVLISTCMDNEQRKHFYWPd*GAVLISTCMDNEQRKHFYWPd*
Variant
ID(s)
Position(s)ChangeDescriptionClinical
significance
Provenance
rs5454068672A>VExAC
gnomAD
rs8949448693V>FTOPMed
gnomAD
rs8949448693V>ITOPMed
gnomAD
rs8949448693V>LTOPMed
gnomAD
rs7598984074P>SLikely benign (Ensembl)ExAC
TOPMed
gnomAD
rs13785690895A>GgnomAD
rs7655381175A>TExAC
TOPMed
gnomAD
rs13785690895A>VgnomAD
rs7640358657L>PExAC
gnomAD
rs13815197607L>VTOPMed
gnomAD
rs7679385668I>MExAC
TOPMed
gnomAD
rs12608257688I>TgnomAD
rs7576405698I>VExAC
gnomAD
rs7558140489L>VExAC
TOPMed
gnomAD
rs37634639210R>PExAC
TOPMed
gnomAD
rs37634639210R>QExAC
TOPMed
gnomAD
rs77965055210R>WExAC
TOPMed
gnomAD
rs77821793611E>*ExAC
gnomAD
rs53030736811E>D1000Genomes
ExAC
gnomAD
rs77318707413P>HExAC
TOPMed
gnomAD
rs77318707413P>LExAC
TOPMed
gnomAD
rs77080492314S>NExAC
TOPMed
gnomAD
rs74676541514S>RExAC
TOPMed
gnomAD
rs77080492314S>TExAC
TOPMed
gnomAD
rs138595640315M>IgnomAD
rs77453982715M>LExAC
TOPMed
gnomAD
rs94436680615M>TVariant of uncertain significance (Ensembl)gnomAD
COSV107280688
rs774539827
15M>Vcosmic curated
ExAC
TOPMed
gnomAD
rs18145436216K>M1000Genomes
ExAC
gnomAD
rs18145436216K>R1000Genomes
ExAC
gnomAD
COSV99174605
rs1750143873
18A>Vcosmic curated
Ensembl
rs77372239819V>AExAC
gnomAD
rs77209931219V>LExAC
TOPMed
gnomAD
COSV5723552520S>P
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs55954271321L>P1000Genomes
rs175014462222I>LTOPMed
gnomAD
rs175014480022I>TTOPMed
rs175014462222I>VTOPMed
gnomAD
COSV5723373823N>H
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
COSV5724175423N>K
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs76110325423N>SExAC
gnomAD
rs76679531624A>EExAC
TOPMed
gnomAD
rs76679531624A>GExAC
TOPMed
gnomAD
rs175014517124A>TgnomAD
rs175014563125I>MgnomAD
rs75413782525I>VExAC
TOPMed
gnomAD
rs75235092626D>GExAC
gnomAD
rs14934790026D>HVariant of uncertain significance (Ensembl)ESP
ExAC
TOPMed
gnomAD
rs14934790026D>YVariant of uncertain significance (Ensembl)ESP
ExAC
TOPMed
gnomAD
rs7434814027T>I1000Genomes
ExAC
TOPMed
gnomAD
rs7434814027T>K1000Genomes
ExAC
TOPMed
gnomAD
rs7434814027T>R1000Genomes
ExAC
TOPMed
gnomAD
rs134186834929R>GgnomAD
COSV57238714
COSV57238714,COSV99174511
COSV99174511
29R>I
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs175014692431P>RTOPMed
rs132663998631P>STOPMed
gnomAD
rs140988165132R>QTOPMed
COSV57233826
rs1215479730
32R>W
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
TOPMed
dbSNP
gnomAD
rs175014745034L>FTOPMed
rs93020791435T>AEnsembl
rs139710848936R>Q
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
TOPMed
dbSNP
gnomAD
rs76896537536R>WVariant of uncertain significance (Ensembl)ExAC
TOPMed
gnomAD
rs74832162037I>LExAC
TOPMed
gnomAD
COSV57235189
rs1750148289
39Q>*cosmic curated
Ensembl
rs7777696139Q>LEnsembl
rs7777696139Q>PEnsembl
TCGA novel40K>T
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA
rs56213836141L>P1000Genomes
ExAC
gnomAD
rs74757161242H>NExAC
TOPMed
gnomAD
rs77131873142H>QExAC
TOPMed
gnomAD
COSV57239732
rs777091905
43L>Pcosmic curated
ExAC
TOPMed
gnomAD
rs14122661644K>E1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs130887283645A>VTOPMed
gnomAD
rs20196613846E>D1000Genomes
ExAC
TOPMed
gnomAD
rs126934727847S>CTOPMed
gnomAD
rs148002931149F>SgnomAD
rs76144084250S>GExAC
gnomAD
rs136501439750S>IgnomAD
rs91604476053E>DTOPMed
gnomAD
rs175028287953E>VTOPMed
rs156159484255E>KTOPMed
rs75034126556K>EExAC
gnomAD
rs76614519656K>NExAC
TOPMed
gnomAD
rs75034126556K>QExAC
gnomAD
COSV5723345558Q>E
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs75865852758Q>HExAC
TOPMed
gnomAD
rs14611132359A>ELikely benign (Ensembl)ESP
ExAC
TOPMed
gnomAD
COSV57234624
rs146111323
59A>VLikely benign (Ensembl)cosmic curated
ESP
ExAC
TOPMed
gnomAD
COSV57238515
rs781262047
60A>Tcosmic curated
ExAC
gnomAD
rs211271002462S>CEnsembl
COSV9917453062S>Y
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs175028461063L>PTOPMed
rs133639761563L>VTOPMed
gnomAD
rs175028482065K>TTOPMed
rs121267281966Q>REnsembl
rs3597716867D>EEnsembl
rs37235894767D>VESP
ExAC
TOPMed
gnomAD
rs78061649568L>PExAC
rs141927442668L>VTOPMed
gnomAD
rs175028552069H>REnsembl
rs76525095471V>ATOPMed
gnomAD
rs76525095471V>GTOPMed
gnomAD
rs211271010071V>IEnsembl
rs74964294272L>FExAC
TOPMed
gnomAD
rs74964294272L>VExAC
TOPMed
gnomAD
rs175028628274T>RgnomAD
COSV57241268
rs769103610
75I>Mcosmic curated
ExAC
TOPMed
gnomAD
COSV57238478
rs1054410972
75I>Vcosmic curated
TOPMed
gnomAD
rs128571437276S>TTOPMed
rs120796337477F>SgnomAD
rs103019662578I>STOPMed
rs131897777580E>GTOPMed
rs131079682381Q>RTOPMed
gnomAD
rs77037591982A>GExAC
TOPMed
gnomAD
COSV5723889582A>T
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs77037591982A>VExAC
TOPMed
gnomAD
rs130838324283V>ATOPMed
rs133619754783V>LgnomAD
rs75939848584Y>CExAC
TOPMed
gnomAD
TCGA novel
rs537786572
85H>Q
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA
1000Genomes
ExAC
gnomAD
rs55097344190A>E1000Genomes
ExAC
TOPMed
gnomAD
rs55097344190A>G1000Genomes
ExAC
TOPMed
gnomAD
rs55097344190A>V1000Genomes
ExAC
TOPMed
gnomAD
rs75628540091A>VExAC
TOPMed
gnomAD
rs125612840392L>FTOPMed
gnomAD
rs137753082893Q>*TOPMed
gnomAD
rs115702732094Q>*TOPMed
gnomAD
rs76651081594Q>HExAC
gnomAD
rs120369701295Q>*TOPMed
gnomAD
rs145320107298N>STOPMed
gnomAD
rs57105704099I>V1000Genomes
ExAC
TOPMed
gnomAD
rs1482030292100H>NgnomAD
rs1262847789101L>FgnomAD
rs755528213102R>GExAC
gnomAD
rs151325955102R>T1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs558248470103Q>E1000Genomes
ExAC
TOPMed
gnomAD
rs140746680104D>E1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1750334604104D>GTOPMed
rs375816472105K>RESP
ExAC
TOPMed
gnomAD
rs746582688106A>GExAC
gnomAD
rs746582688106A>VExAC
gnomAD
rs1202969929108A>GTOPMed
COSV57236399108A>S
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs1455530315108A>TTOPMed
gnomAD
rs1750335476110V>ITOPMed
rs201107215111N>D1000Genomes
ExAC
gnomAD
rs1750335644111N>STOPMed
COSV57238368
rs914929373
112T>Mcosmic curated
Ensembl
rs914929373112T>REnsembl
rs1229635719113W>*TOPMed
rs745867369113W>CExAC
gnomAD
TCGA novel113W>R
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA
rs1229635719113W>STOPMed
COSV57237691
rs1750336428
114S>F
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
TOPMed
rs769701802114S>PExAC
gnomAD
rs1750336591115S>PTOPMed
rs762841146116M>IExAC
TOPMed
gnomAD
rs775191934116M>VExAC
gnomAD
rs1309988493117G>CgnomAD
TCGA novel117G>V
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA
rs760914074120T>RExAC
gnomAD
rs200380253121V>ATOPMed
gnomAD
rs1234341234122E>DTOPMed
gnomAD
rs766633557122E>QExAC
gnomAD
rs753944491123K>NExAC
TOPMed
gnomAD
COSV99174553124F>C
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs574085904124F>L1000Genomes
ExAC
gnomAD
rs753094653125R>QExAC
TOPMed
gnomAD
rs765803405125R>WVariant of uncertain significance (Ensembl)ExAC
TOPMed
gnomAD
rs1229853458126Q>*TOPMed
gnomAD
COSV57235859127R>I
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
COSV104569872
rs758800834
127R>Kcosmic curated
ExAC
TOPMed
gnomAD
rs1750338164127R>STOPMed
rs758800834127R>TExAC
TOPMed
gnomAD
VAR_061122
COSV57234444
rs1129495
128I>SUniProt
cosmic curated
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs1363393717128I>VgnomAD
rs957169526129L>VTOPMed
gnomAD
rs1025621738130A>TEnsembl
rs1164100338130A>VTOPMed
COSV57233492
rs1296041017
131P>Scosmic curated
TOPMed
gnomAD
TCGA novel132C>A
Variant assessed as Somatic; HIGH impact. (NCI-TCGA)
NCI-TCGA
rs756886920132C>GExAC
gnomAD
rs1750338942132C>STOPMed
rs1750338942132C>YTOPMed
rs1183393349137V>ATOPMed
rs376187299137V>FESP
ExAC
TOPMed
gnomAD
rs376187299137V>IESP
ExAC
TOPMed
gnomAD
rs1462125184139W>*TOPMed
rs1463571885139W>*gnomAD
COSV99174519139W>C
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs1398882969139W>RgnomAD
rs910967671140Q>RTOPMed
rs146988130142N>DESP
ExAC
TOPMed
gnomAD
COSV57235343
rs1382996563
142N>K
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
TOPMed
gnomAD
rs773352383144Q>HTOPMed
gnomAD
rs775417305145M>TExAC
gnomAD
rs1751949934145M>VTOPMed
rs1315872752147H>DEnsembl
rs2112772607147H>QEnsembl
rs1751950404148S>CEnsembl
rs1751950282148S>PEnsembl
rs1751950677149A>GTOPMed
rs538653158149A>T1000Genomes
ExAC
gnomAD
COSV57237251150Q>*
Variant assessed as Somatic; HIGH impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs1751950788150Q>EEnsembl
rs752024302150Q>HExAC
TOPMed
gnomAD
rs552174758150Q>R1000Genomes
ExAC
TOPMed
gnomAD
rs762191409151A>EExAC
gnomAD
COSV57236903151A>T
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs762191409151A>VExAC
gnomAD
rs1316627134152K>QgnomAD
rs767815358152K>RExAC
TOPMed
gnomAD
TCGA novel154K>N
Variant assessed as Somatic; HIGH impact. (NCI-TCGA)
NCI-TCGA
rs138138184154K>Q1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1751951836154K>TTOPMed
rs1208365445156P>LTOPMed
gnomAD
rs1314043352156P>S
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
TOPMed
dbSNP
rs755717054157Q>RExAC
gnomAD
COSV57240620158A>V
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs753266343161Q>*ExAC
gnomAD
rs1751953129161Q>PTOPMed
gnomAD
rs1428721632162L>FTOPMed
gnomAD
rs1177888903162L>PgnomAD
COSV99174503
rs1000102901
163G>*cosmic curated
TOPMed
gnomAD
rs779016058163G>EExAC
gnomAD
COSV57236754
COSV99174503
rs1000102901
COSV57236754,COSV99174503
163G>R
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
TOPMed
dbSNP
gnomAD
rs1431877121165N>KTOPMed
gnomAD
rs1415024043165N>STOPMed
gnomAD
rs373245497166N>KVariant of uncertain significance (Ensembl)ESP
ExAC
TOPMed
gnomAD
rs1751954879168D>NEnsembl
rs1208063014171S>CgnomAD
rs1274482609171S>IgnomAD
COSV99174581173E>*
Variant assessed as Somatic; HIGH impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs1580366960174K>REnsembl
rs764161992175V>LExAC
gnomAD
rs1751360498176L>VEnsembl
rs2112718742177V>GEnsembl
rs1188598687178E>*gnomAD
rs751467892178E>VExAC
gnomAD
rs1233674110179F>ITOPMed
rs757019599180S>GExAC
TOPMed
gnomAD
rs757019599180S>RExAC
TOPMed
gnomAD
rs780977219181H>QExAC
TOPMed
gnomAD
rs930642030182K>ETOPMed
rs1038535223182K>MTOPMed
gnomAD
rs1751361418182K>NTOPMed
COSV57236797
rs1298570667
183E>Kcosmic curated
TOPMed
rs1338861452185F>YTOPMed
gnomAD
COSV99174539186D>Y
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs1561411848187F>LEnsembl
rs1002303078188Y>*TOPMed
gnomAD
rs755180681188Y>CExAC
gnomAD
rs749541250188Y>HVariant of uncertain significance (Ensembl)ExAC
TOPMed
gnomAD
COSV57234309
rs1751362500
190K>N
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
TOPMed
gnomAD
TCGA novel190K>R
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA
rs148262275192E>GESP
ExAC
gnomAD
COSV57238582192E>K
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs148262275192E>VESP
ExAC
gnomAD
COSV99174536
rs1373057065
193T>Acosmic curated
TOPMed
gnomAD
rs752983046193T>SExAC
TOPMed
gnomAD
rs141415135194I>LESP
ExAC
TOPMed
gnomAD
rs141415135194I>VESP
ExAC
TOPMed
gnomAD
rs867503044195Q>*gnomAD
rs1751392177195Q>RTOPMed
rs777760753197Q>*ExAC
gnomAD
rs751623825197Q>LExAC
gnomAD
rs751623825197Q>RExAC
gnomAD
COSV99174512198L>P
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs1156578803199D>ETOPMed
rs1421091928202T>AgnomAD
rs757242008202T>RExAC
gnomAD
COSV57240509
COSV57240509,COSV99174496
COSV99174496
203*>=
Variant assessed as Somatic; LOW impact. (NCI-TCGA)
NCI-TCGA Cosmic
rs781732166203*>CExAC
TOPMed
gnomAD
COSV57240509
COSV57240509,COSV99174496
COSV99174496
203*>L
Variant assessed as Somatic; HIGH impact. (NCI-TCGA)
NCI-TCGA Cosmic
COSV57235277203*>R
Variant assessed as Somatic; HIGH impact. (NCI-TCGA)
NCI-TCGA Cosmic
rs781732166203*>WExAC
TOPMed
gnomAD
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