Q9Y680 · FKBP7_HUMAN
- ProteinPeptidyl-prolyl cis-trans isomerase FKBP7
- GeneFKBP7
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids222 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
PPIases accelerate the folding of proteins during protein synthesis.
Miscellaneous
Binds calcium.
Catalytic activity
- [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 158 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 160 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 162 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 164 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 169 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 202 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 204 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 206 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 213 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | endoplasmic reticulum lumen | |
Molecular Function | calcium ion binding | |
Molecular Function | FK506 binding | |
Molecular Function | peptidyl-prolyl cis-trans isomerase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeptidyl-prolyl cis-trans isomerase FKBP7
- EC number
- Short namesPPIase FKBP7
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9Y680
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 247 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MPKTMHFLFRFIVFFYLWGLFTA | ||||||
Chain | PRO_0000025513 | 24-222 | Peptidyl-prolyl cis-trans isomerase FKBP7 | |||
Sequence: QRQKKEESTEEVKIEVLHRPENCSKTSKKGDLLNAHYDGYLAKDGSKFYCSRTQNEGHPKWFVLGVGQVIKGLDIAMTDMCPGEKRKVVIPPSFAYGKEGYAEGKIPPDATLIFEIELYAVTKGPRSIETFKQIDMDNDRQLSKAEINLYLQREFEKDEKPRDKSYQDAVLEDIFKKNDHDGDGFISPKEYNVYQHDEL | ||||||
Glycosylation | 45 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Post-translational modification
Glycosylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 53-145 | PPIase FKBP-type | ||||
Sequence: GDLLNAHYDGYLAKDGSKFYCSRTQNEGHPKWFVLGVGQVIKGLDIAMTDMCPGEKRKVVIPPSFAYGKEGYAEGKIPPDATLIFEIELYAVT | ||||||
Domain | 145-180 | EF-hand 1 | ||||
Sequence: TKGPRSIETFKQIDMDNDRQLSKAEINLYLQREFEK | ||||||
Domain | 189-222 | EF-hand 2 | ||||
Sequence: YQDAVLEDIFKKNDHDGDGFISPKEYNVYQHDEL | ||||||
Region | 200-222 | Disordered | ||||
Sequence: KNDHDGDGFISPKEYNVYQHDEL | ||||||
Motif | 219-222 | Retention in the endoplasmic reticulum | ||||
Sequence: HDEL |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 3 isoforms produced by Alternative splicing.
Q9Y680-2
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name2
- Length222
- Mass (Da)25,794
- Last updated2018-03-28 v2
- Checksum362957BAD3C5C2A6
Q9Y680-3
- Name3
- Differences from canonical
- 125-125: Missing
Q9Y680-1
- Name1
- NoteMay be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F8WCU2 | F8WCU2_HUMAN | FKBP7 | 74 | ||
F8WBF2 | F8WBF2_HUMAN | FKBP7 | 86 | ||
B4DRE2 | B4DRE2_HUMAN | FKBP7 | 133 | ||
H7BZJ4 | H7BZJ4_HUMAN | FKBP7 | 67 | ||
A0A8I5KRR8 | A0A8I5KRR8_HUMAN | FKBP7 | 172 |
Sequence caution
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 124 | in Ref. 1; AAD40379 | ||||
Sequence: Y → H | ||||||
Alternative sequence | VSP_041018 | 125 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_059387 | 125-127 | in isoform 1 | |||
Sequence: AEG → GST | ||||||
Alternative sequence | VSP_059388 | 128-222 | in isoform 1 | |||
Sequence: Missing | ||||||
Sequence conflict | 200 | in Ref. 5; AAQ57208 | ||||
Sequence: K → M |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF092137 EMBL· GenBank· DDBJ | AAD40379.1 EMBL· GenBank· DDBJ | mRNA | ||
AF100751 EMBL· GenBank· DDBJ | AAD43015.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
AY359015 EMBL· GenBank· DDBJ | AAQ89374.1 EMBL· GenBank· DDBJ | mRNA | ||
AK292145 EMBL· GenBank· DDBJ | BAF84834.1 EMBL· GenBank· DDBJ | mRNA | ||
BT007122 EMBL· GenBank· DDBJ | AAP35786.1 EMBL· GenBank· DDBJ | mRNA | ||
AY353086 EMBL· GenBank· DDBJ | AAQ57208.1 EMBL· GenBank· DDBJ | mRNA | ||
AC009948 EMBL· GenBank· DDBJ | AAX88883.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC009711 EMBL· GenBank· DDBJ | AAH09711.1 EMBL· GenBank· DDBJ | mRNA |