Q9Y5V3 · MAGD1_HUMAN
- ProteinMelanoma-associated antigen D1
- GeneMAGED1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids778 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Cellular Component | protein-containing complex | |
Molecular Function | identical protein binding | |
Molecular Function | transcription coactivator activity | |
Biological Process | circadian regulation of gene expression | |
Biological Process | negative regulation of epithelial cell proliferation | |
Biological Process | negative regulation of protein localization to nucleus | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | positive regulation of apoptotic signaling pathway | |
Biological Process | positive regulation of branching involved in ureteric bud morphogenesis | |
Biological Process | protein localization to nucleus | |
Biological Process | regulation of apoptotic process | |
Biological Process | regulation of circadian rhythm | |
Biological Process | regulation of DNA-templated transcription |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMelanoma-associated antigen D1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9Y5V3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Note: Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_060070 | 238 | in dbSNP:rs12689461 | |||
Sequence: L → M |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 719 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000156723 | 1-778 | UniProt | Melanoma-associated antigen D1 | |||
Sequence: MAQKMDCGAGLLGFQAEASVEDSALLMQTLMEAIQISEAPPTNQATAAASPQSSQPPTANEMADIQVSAAAARPKSAFKVQNATTKGPNGVYDFSQAHNAKDVPNTQPKAAFKSQNATPKGPNAAYDFSQAATTGELAANKSEMAFKAQNATTKVGPNATYNFSQSLNANDLANSRPKTPFKAWNDTTKAPTADTQTQNVNQAKMATSQADIETDPGISEPDGATAQTSADGSQAQNLESRTIIRGKRTRKINNLNVEENSSGDQRRAPLAAGTWRSAPVPVTTQNPPGAPPNVLWQTPLAWQNPSGWQNQTARQTPPARQSPPARQTPPAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPDWQGPPDWPLPPDWPLPPDWPLPTDWPLPPDWIPADWPIPPDWQNLRPSPNLRPSPNSRASQNPGAAQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARTRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQTFAGPIIGPGGTASANFAANFGAIGFFWVE | |||||||
Modified residue | 92 | UniProt | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 92 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 126 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 161 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 316 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 322 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A. Interacts with TRIM28 and PJA1. Interacts with NGFR/p75NTR and RORA.
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, repeat, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 41-60 | Disordered | ||||
Sequence: PTNQATAAASPQSSQPPTAN | ||||||
Compositional bias | 78-92 | Polar residues | ||||
Sequence: FKVQNATTKGPNGVY | ||||||
Region | 78-123 | Disordered | ||||
Sequence: FKVQNATTKGPNGVYDFSQAHNAKDVPNTQPKAAFKSQNATPKGPN | ||||||
Compositional bias | 99-123 | Polar residues | ||||
Sequence: NAKDVPNTQPKAAFKSQNATPKGPN | ||||||
Compositional bias | 182-214 | Polar residues | ||||
Sequence: KAWNDTTKAPTADTQTQNVNQAKMATSQADIET | ||||||
Region | 182-333 | Disordered | ||||
Sequence: KAWNDTTKAPTADTQTQNVNQAKMATSQADIETDPGISEPDGATAQTSADGSQAQNLESRTIIRGKRTRKINNLNVEENSSGDQRRAPLAAGTWRSAPVPVTTQNPPGAPPNVLWQTPLAWQNPSGWQNQTARQTPPARQSPPARQTPPAWQ | ||||||
Compositional bias | 221-242 | Polar residues | ||||
Sequence: PDGATAQTSADGSQAQNLESRT | ||||||
Repeat | 296-301 | 1 | ||||
Sequence: WQTPLA | ||||||
Region | 296-444 | 22 X 6 AA tandem repeats of W-[PQ]-X-P-X-X | ||||
Sequence: WQTPLAWQNPSGWQNQTARQTPPARQSPPARQTPPAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPDWQGPPDWPLPPDWPLPPDWPLPTDWPLPPDWIPADWPIPPDWQNLRP | ||||||
Compositional bias | 297-321 | Polar residues | ||||
Sequence: QTPLAWQNPSGWQNQTARQTPPARQ | ||||||
Repeat | 302-307 | 2 | ||||
Sequence: WQNPSG | ||||||
Repeat | 308-313 | 3 | ||||
Sequence: WQNQTA | ||||||
Repeat | 332-337 | 4 | ||||
Sequence: WQNPVA | ||||||
Repeat | 338-343 | 5 | ||||
Sequence: WQNPVI | ||||||
Repeat | 344-349 | 6 | ||||
Sequence: WPNPVI | ||||||
Repeat | 350-355 | 7 | ||||
Sequence: WQNPVI | ||||||
Repeat | 356-361 | 8 | ||||
Sequence: WPNPIV | ||||||
Repeat | 362-367 | 9 | ||||
Sequence: WPGPVV | ||||||
Repeat | 368-373 | 10 | ||||
Sequence: WPNPLA | ||||||
Repeat | 374-379 | 11 | ||||
Sequence: WQNPPG | ||||||
Region | 376-412 | Disordered | ||||
Sequence: NPPGWQTPPGWQTPPGWQGPPDWQGPPDWPLPPDWPL | ||||||
Repeat | 380-385 | 12 | ||||
Sequence: WQTPPG | ||||||
Repeat | 386-391 | 13 | ||||
Sequence: WQTPPG | ||||||
Repeat | 392-397 | 14 | ||||
Sequence: WQGPPD | ||||||
Repeat | 398-403 | 15 | ||||
Sequence: WQGPPD | ||||||
Repeat | 404-409 | 16 | ||||
Sequence: WPLPPD | ||||||
Repeat | 410-415 | 17 | ||||
Sequence: WPLPPD | ||||||
Repeat | 416-421 | 18 | ||||
Sequence: WPLPTD | ||||||
Repeat | 422-427 | 19 | ||||
Sequence: WPLPPD | ||||||
Repeat | 428-432 | 20; approximate | ||||
Sequence: WIPAD | ||||||
Repeat | 433-438 | 21 | ||||
Sequence: WPIPPD | ||||||
Repeat | 439-444 | 22 | ||||
Sequence: WQNLRP | ||||||
Region | 440-466 | Disordered | ||||
Sequence: QNLRPSPNLRPSPNSRASQNPGAAQPR | ||||||
Compositional bias | 444-461 | Polar residues | ||||
Sequence: PSPNLRPSPNSRASQNPG | ||||||
Domain | 471-669 | MAGE | ||||
Sequence: LQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEA |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9Y5V3-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length778
- Mass (Da)86,161
- Last updated2005-04-26 v3
- ChecksumD818690052D166CE
Q9Y5V3-2
- Name2
- Differences from canonical
- 15-15: Q → QNPDACRAVCHPLPQPPASTLPLSAFPTLCDPPYSQLRDPPAVLSCYCTPLGASPAP
Sequence caution
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_009286 | 15 | in isoform 2 | |||
Sequence: Q → QNPDACRAVCHPLPQPPASTLPLSAFPTLCDPPYSQLRDPPAVLSCYCTPLGASPAP | ||||||
Compositional bias | 78-92 | Polar residues | ||||
Sequence: FKVQNATTKGPNGVY | ||||||
Compositional bias | 99-123 | Polar residues | ||||
Sequence: NAKDVPNTQPKAAFKSQNATPKGPN | ||||||
Sequence conflict | 119 | in Ref. 1; AAG09704 | ||||
Sequence: P → S | ||||||
Compositional bias | 182-214 | Polar residues | ||||
Sequence: KAWNDTTKAPTADTQTQNVNQAKMATSQADIET | ||||||
Compositional bias | 221-242 | Polar residues | ||||
Sequence: PDGATAQTSADGSQAQNLESRT | ||||||
Compositional bias | 297-321 | Polar residues | ||||
Sequence: QTPLAWQNPSGWQNQTARQTPPARQ | ||||||
Compositional bias | 444-461 | Polar residues | ||||
Sequence: PSPNLRPSPNSRASQNPG |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF217963 EMBL· GenBank· DDBJ | AAG09704.1 EMBL· GenBank· DDBJ | mRNA | ||
AF258554 EMBL· GenBank· DDBJ | AAG23757.1 EMBL· GenBank· DDBJ | mRNA | ||
AF300328 EMBL· GenBank· DDBJ | AAQ14483.1 EMBL· GenBank· DDBJ | mRNA | ||
AL929410 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC014070 EMBL· GenBank· DDBJ | AAH14070.1 EMBL· GenBank· DDBJ | mRNA | ||
BC032473 EMBL· GenBank· DDBJ | AAH32473.1 EMBL· GenBank· DDBJ | mRNA | ||
AF124440 EMBL· GenBank· DDBJ | AAD31421.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AL133628 EMBL· GenBank· DDBJ | CAB63752.1 EMBL· GenBank· DDBJ | mRNA | ||
AF132205 EMBL· GenBank· DDBJ | AAG35551.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |