Q9Y5R4 · HEMK1_HUMAN

  • Protein
    MTRF1L release factor glutamine methyltransferase
  • Gene
    HEMK1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factors MTRF1, MTRF1L, MRPL58/ICT1 and MTRFR.

Catalytic activity

Features

Showing features for binding site.

133850100150200250300
TypeIDPosition(s)Description
Binding site167-171S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site190S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site225S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site239S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site239-242substrate

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular FunctionDNA binding
Molecular FunctionN-methyltransferase activity
Molecular Functionprotein methyltransferase activity
Molecular Functionprotein-(glutamine-N5) methyltransferase activity
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    MTRF1L release factor glutamine methyltransferase
  • EC number
  • Alternative names
    • HemK methyltransferase family member 1
    • M.HsaHemKP

Gene names

    • Name
      HEMK1
    • Synonyms
      HEMK

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9Y5R4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_049503192in dbSNP:rs2232250
Natural variantVAR_049504200in dbSNP:rs2232251

Variants

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The viewer provides 418 variants from UniProt as well as other sources including ClinVar and dbSNP.

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Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001571781-338MTRF1L release factor glutamine methyltransferase

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    338
  • Mass (Da)
    38,231
  • Last updated
    1999-11-01 v1
  • Checksum
    5AB5DF554D9978B4
MELWGRMLWALLSGPGRRGSTRGWAFSSWQPQPPLAGLSSAIELVSHWTGVFEKRGIPEARESSEYIVAHVLGAKTFQSLRPALWTQPLTSQQLQCIRELSSRRLQRMPVQYILGEWDFQGLSLRMVPPVFIPRPETEELVEWVLEEVAQRSHAVGSPGSPLILEVGCGSGAISLSLLSQLPQSRVIAVDKREAAISLTHENAQRLRLQDRIWIIHLDMTSERSWTHLPWGPMDLIVSNPPYVFHQDMEQLAPEIRSYEDPAALDGGEEGMDIITHILALAPRLLKDSGSIFLEVDPRHPELVSSWLQSRPDLYLNLVAVRRDFCGRPRFLHIRRSGP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H7C258H7C258_HUMANHEMK1124
F2Z2F0F2Z2F0_HUMANHEMK188

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF131220
EMBL· GenBank· DDBJ
AAD26417.1
EMBL· GenBank· DDBJ
mRNA
AF172244
EMBL· GenBank· DDBJ
AAD51328.1
EMBL· GenBank· DDBJ
mRNA
BC000781
EMBL· GenBank· DDBJ
AAH00781.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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