Q9Y473 · ZN175_HUMAN

  • Protein
    Zinc finger protein 175
  • Gene
    ZNF175
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleolus
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular FunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding
Biological Processdefense response to virus
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Community curation (1)

Community annotation

The subsequence LSQKPQVLGPEKQDGSCEASVSFEDVTVDFSREEWQQLDPAQRCLYRDVMLELYSHLFAVGYHIPNPEVIFRMLKEKEPR, which contains the KRAB domain, shows transcriptional repressor activity in a high-throughput recruitment assay.

SourceSubmission dateContributor
PubMed:333267460000-0002-4108-0575

Names & Taxonomy

Protein names

  • Recommended name
    Zinc finger protein 175
  • Alternative names
    • Zinc finger protein OTK18

Gene names

    • Name
      ZNF175

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9Y473
  • Secondary accessions
    • A8K9H2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_061938363in dbSNP:rs60097262
Natural variantVAR_052789505in dbSNP:rs3764548
Natural variantVAR_083478622in dbSNP:rs746283244

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 784 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

Type
IDPosition(s)Source
Description
ChainPRO_00000474401-711UniProtZinc finger protein 175
Modified residue (large scale data)10PTMeXchangeSumoylated lysine
Modified residue (large scale data)119PTMeXchangeSumoylated lysine
Modified residue (large scale data)147PTMeXchangeSumoylated lysine
Modified residue (large scale data)165PTMeXchangeSumoylated lysine
Modified residue (large scale data)253PTMeXchangeSumoylated lysine
Modified residue (large scale data)268PTMeXchangeSumoylated lysine
Modified residue (large scale data)277PTMeXchangeSumoylated lysine
Modified residue (large scale data)398PTMeXchangeSumoylated lysine
Modified residue (large scale data)411PTMeXchangeSumoylated lysine
Modified residue (large scale data)431PTMeXchangeSumoylated lysine
Modified residue (large scale data)501PTMeXchangeSumoylated lysine
Modified residue (large scale data)523PTMeXchangeSumoylated lysine
Modified residue (large scale data)538PTMeXchangeSumoylated lysine
Modified residue (large scale data)543PTMeXchangeSumoylated lysine
Modified residue (large scale data)557PTMeXchangeSumoylated lysine
Modified residue (large scale data)571PTMeXchangeSumoylated lysine
Modified residue (large scale data)585PTMeXchangeSumoylated lysine
Modified residue (large scale data)604PTMeXchangeSumoylated lysine
Modified residue (large scale data)688PTMeXchangeSumoylated lysine
Modified residue (large scale data)700PTMeXchangeSumoylated lysine
Modified residue (large scale data)706PTMeXchangeSumoylated lysine

Proteomic databases

2D gel databases

PTM databases

Expression

Tissue specificity

Ubiquitous.

Induction

By HIV-1 infection.

Gene expression databases

Organism-specific databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain, zinc finger, motif.

Type
IDPosition(s)Description
Compositional bias1-11Polar residues
Region1-21Disordered
Domain27-98KRAB
Zinc finger279-301C2H2-type 1; atypical
Zinc finger307-329C2H2-type 2; atypical
Zinc finger335-357C2H2-type 3
Motif359-362Nuclear localization signal
Zinc finger363-385C2H2-type 4
Zinc finger391-413C2H2-type 5
Zinc finger419-441C2H2-type 6
Zinc finger447-469C2H2-type 7
Zinc finger475-497C2H2-type 8
Zinc finger503-525C2H2-type 9
Zinc finger531-553C2H2-type 10
Zinc finger559-581C2H2-type 11
Zinc finger587-609C2H2-type 12
Zinc finger615-637C2H2-type 13
Zinc finger643-665C2H2-type 14
Zinc finger671-693C2H2-type 15

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    711
  • Mass (Da)
    81,609
  • Last updated
    1999-11-01 v1
  • MD5 Checksum
    B51397F4D1928F6E4CDFA31B4BF49158
MPADVNLSQKPQVLGPEKQDGSCEASVSFEDVTVDFSREEWQQLDPAQRCLYRDVMLELYSHLFAVGYHIPNPEVIFRMLKEKEPRVEEAEVSHQRCQEREFGLEIPQKEISKKASFQKDMVGEFTRDGSWCSILEELRLDADRTKKDEQNQIQPMSHSAFFNKKTLNTESNCEYKDPGKMIRTRPHLASSQKQPQKCCLFTESLKLNLEVNGQNESNDTEQLDDVVGSGQLFSHSSSDACSKNIHTGETFCKGNQCRKVCGHKQSLKQHQIHTQKKPDGCSECGGSFTQKSHLFAQQRIHSVGNLHECGKCGKAFMPQLKLSVYLTDHTGDIPCICKECGKVFIQRSELLTHQKTHTRKKPYKCHDCGKAFFQMLSLFRHQRTHSREKLYECSECGKGFSQNSTLIIHQKIHTGERQYACSECGKAFTQKSTLSLHQRIHSGQKSYVCIECGQAFIQKAHLIVHQRSHTGEKPYQCHNCGKSFISKSQLDIHHRIHTGEKPYECSDCGKTFTQKSHLNIHQKIHTGERHHVCSECGKAFNQKSILSMHQRIHTGEKPYKCSECGKAFTSKSQFKEHQRIHTGEKPYVCTECGKAFNGRSNFHKHQITHTRERPFVCYKCGKAFVQKSELITHQRTHMGEKPYECLDCGKSFSKKPQLKVHQRIHTGERPYVCSECGKAFNNRSNFNKHQTTHTRDKSYKCSYSVKGFTKQ

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
G3V1K8G3V1K8_HUMANZNF175112
M0R013M0R013_HUMANZNF17570
F5GZI7F5GZI7_HUMANZNF17551

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-11Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D50419
EMBL· GenBank· DDBJ
BAA23362.1
EMBL· GenBank· DDBJ
mRNA
AK292687
EMBL· GenBank· DDBJ
BAF85376.1
EMBL· GenBank· DDBJ
mRNA
AC018755
EMBL· GenBank· DDBJ
AAF87843.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471135
EMBL· GenBank· DDBJ
EAW72030.1
EMBL· GenBank· DDBJ
Genomic DNA
BC052997
EMBL· GenBank· DDBJ
AAH52997.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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