Q9Y473 · ZN175_HUMAN
- ProteinZinc finger protein 175
- GeneZNF175
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids711 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleolus | |
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | DNA-binding transcription repressor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | RNA polymerase II transcription regulatory region sequence-specific DNA binding | |
Biological Process | defense response to virus | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Community annotation
The subsequence LSQKPQVLGPEKQDGSCEASVSFEDVTVDFSREEWQQLDPAQRCLYRDVMLELYSHLFAVGYHIPNPEVIFRMLKEKEPR, which contains the KRAB domain, shows transcriptional repressor activity in a high-throughput recruitment assay.
Source | Submission date | Contributor |
---|---|---|
PubMed:33326746 | ![]() |
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein 175
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9Y473
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | VAR_061938 | 363 | in dbSNP:rs60097262 | ||
Natural variant | VAR_052789 | 505 | in dbSNP:rs3764548 | ||
Natural variant | VAR_083478 | 622 | in dbSNP:rs746283244 | ||
Variants
![](/variants.8e7f84.jpg)
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 784 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Chain | PRO_0000047440 | 1-711 | UniProt | Zinc finger protein 175 | ||
Modified residue (large scale data) | 10 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 119 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 147 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 165 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 253 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 268 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 277 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 398 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 411 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 431 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 501 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 523 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 538 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 543 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 557 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 571 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 585 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 604 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 688 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 700 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 706 | PTMeXchange | Sumoylated lysine | |||
Proteomic databases
2D gel databases
PTM databases
Expression
Tissue specificity
Ubiquitous.
Induction
By HIV-1 infection.
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | Q9Y473 | ALAS1 P13196 | 6 | EBI-3438881, EBI-3905054 | |
BINARY | Q9Y473 | KRTAP10-7 P60409 | 3 | EBI-3438881, EBI-10172290 | |
BINARY | Q9Y473 | PSTPIP1 O43586 | 3 | EBI-3438881, EBI-1050964 | |
BINARY | Q9Y473 | ZNF250 P15622-3 | 3 | EBI-3438881, EBI-10177272 | |
BINARY | Q9Y473 | ZNF264 O43296 | 5 | EBI-3438881, EBI-4395808 | |
BINARY | Q9Y473 | ZNF264 Q14C61 | 3 | EBI-3438881, EBI-2826570 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain, zinc finger, motif.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-11 | Polar residues | |||
Region | 1-21 | Disordered | |||
Domain | 27-98 | KRAB | |||
Zinc finger | 279-301 | C2H2-type 1; atypical | |||
Zinc finger | 307-329 | C2H2-type 2; atypical | |||
Zinc finger | 335-357 | C2H2-type 3 | |||
Motif | 359-362 | Nuclear localization signal | |||
Zinc finger | 363-385 | C2H2-type 4 | |||
Zinc finger | 391-413 | C2H2-type 5 | |||
Zinc finger | 419-441 | C2H2-type 6 | |||
Zinc finger | 447-469 | C2H2-type 7 | |||
Zinc finger | 475-497 | C2H2-type 8 | |||
Zinc finger | 503-525 | C2H2-type 9 | |||
Zinc finger | 531-553 | C2H2-type 10 | |||
Zinc finger | 559-581 | C2H2-type 11 | |||
Zinc finger | 587-609 | C2H2-type 12 | |||
Zinc finger | 615-637 | C2H2-type 13 | |||
Zinc finger | 643-665 | C2H2-type 14 | |||
Zinc finger | 671-693 | C2H2-type 15 | |||
Sequence similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length711
- Mass (Da)81,609
- Last updated1999-11-01 v1
- MD5 ChecksumB51397F4D1928F6E4CDFA31B4BF49158
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-11 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D50419 EMBL· GenBank· DDBJ | BAA23362.1 EMBL· GenBank· DDBJ | mRNA | ||
AK292687 EMBL· GenBank· DDBJ | BAF85376.1 EMBL· GenBank· DDBJ | mRNA | ||
AC018755 EMBL· GenBank· DDBJ | AAF87843.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471135 EMBL· GenBank· DDBJ | EAW72030.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC052997 EMBL· GenBank· DDBJ | AAH52997.1 EMBL· GenBank· DDBJ | mRNA |