Q9Y3M2 · CBY1_HUMAN
- ProteinProtein chibby homolog 1
- GeneCBY1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids126 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
Miscellaneous
'Chibby' is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | centriole | |
Cellular Component | ciliary basal body | |
Cellular Component | cytosol | |
Cellular Component | nuclear speck | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Cellular Component | trans-Golgi network | |
Molecular Function | beta-catenin binding | |
Molecular Function | identical protein binding | |
Molecular Function | protein homodimerization activity | |
Biological Process | canonical Wnt signaling pathway | |
Biological Process | cardiac muscle cell differentiation | |
Biological Process | cilium assembly | |
Biological Process | fat cell differentiation | |
Biological Process | floor plate development | |
Biological Process | negative regulation of canonical Wnt signaling pathway | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | negative regulation of Wnt signaling pathway | |
Biological Process | protein homotetramerization | |
Biological Process | protein localization |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein chibby homolog 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9Y3M2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 152 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000058354 | 1-126 | UniProt | Protein chibby homolog 1 | |||
Sequence: MPFFGNTFSPKKTPPRKSASLSNLHSLDRSTREVELGLEYGSPTMNLAGQSLKFENGQWIAETGVSGGVDRREVQRLRRRNQQLEEENNLLRLKVDILLDMLSESTAESHLMEKELDELRISRKRK | |||||||
Modified residue | 9 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 9 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 18 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 20 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 20 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 22 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 26 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Homodimer. Interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of CTNNB1 (PubMed:12712206, PubMed:16424001).
Interacts (C-terminus) with TCIM (C-terminus), TCIM competes with CTNNB1 for the interaction with CBY1 (PubMed:16424001).
Interacts with FAM92A; this interaction facilitates targeting of FAM92A to cilium basal body (PubMed:27528616, PubMed:30395363).
Interacts with CIBAR2 (PubMed:27528616).
Interacts (C-terminus) with TCIM (C-terminus), TCIM competes with CTNNB1 for the interaction with CBY1 (PubMed:16424001).
Interacts with FAM92A; this interaction facilitates targeting of FAM92A to cilium basal body (PubMed:27528616, PubMed:30395363).
Interacts with CIBAR2 (PubMed:27528616).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9Y3M2 | CFAP53 Q96M91 | 4 | EBI-947308, EBI-742422 | |
BINARY | Q9Y3M2 | CIBAR1 A1XBS5 | 4 | EBI-947308, EBI-2349888 | |
BINARY | Q9Y3M2 | CIBAR1 A1XBS5-3 | 3 | EBI-947308, EBI-12348777 | |
BINARY | Q9Y3M2 | DZIP1L Q8IYY4 | 4 | EBI-947308, EBI-10264440 | |
BINARY | Q9Y3M2 | ENKD1 Q9H0I2 | 3 | EBI-947308, EBI-744099 | |
BINARY | Q9Y3M2 | FAM161B Q96MY7 | 3 | EBI-947308, EBI-7225287 | |
BINARY | Q9Y3M2 | GORASP2 Q9H8Y8 | 3 | EBI-947308, EBI-739467 | |
BINARY | Q9Y3M2 | LNX1 Q8TBB1 | 3 | EBI-947308, EBI-739832 | |
BINARY | Q9Y3M2 | RALBP1 Q15311 | 4 | EBI-947308, EBI-749285 | |
BINARY | Q9Y3M2 | RASSF10 A6NK89 | 3 | EBI-947308, EBI-6912267 | |
BINARY | Q9Y3M2 | TNFAIP8L3 Q5GJ75 | 3 | EBI-947308, EBI-14222571 | |
BINARY | Q9Y3M2 | TSG101 Q99816 | 3 | EBI-947308, EBI-346882 | |
BINARY | Q9Y3M2 | TTC23L Q6PF05-3 | 3 | EBI-947308, EBI-10182647 | |
BINARY | Q9Y3M2 | YWHAE P62258 | 4 | EBI-947308, EBI-356498 | |
BINARY | Q9Y3M2 | YWHAZ P63104 | 4 | EBI-947308, EBI-347088 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-26 | Disordered | ||||
Sequence: MPFFGNTFSPKKTPPRKSASLSNLHS | ||||||
Compositional bias | 11-26 | Polar residues | ||||
Sequence: KKTPPRKSASLSNLHS | ||||||
Region | 60-112 | Minimal region for the interaction with PKD2 | ||||
Sequence: IAETGVSGGVDRREVQRLRRRNQQLEEENNLLRLKVDILLDMLSESTAESHLM | ||||||
Coiled coil | 67-125 | |||||
Sequence: GGVDRREVQRLRRRNQQLEEENNLLRLKVDILLDMLSESTAESHLMEKELDELRISRKR |
Sequence similarities
Belongs to the chibby family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length126
- Mass (Da)14,470
- Last updated1999-11-01 v1
- Checksum0D243AD2CC436E55
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 11-26 | Polar residues | ||||
Sequence: KKTPPRKSASLSNLHS | ||||||
Sequence conflict | 73 | in Ref. 1; AAL56062 | ||||
Sequence: E → K |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF331041 EMBL· GenBank· DDBJ | AAL56062.1 EMBL· GenBank· DDBJ | mRNA | ||
AB111855 EMBL· GenBank· DDBJ | BAC78839.1 EMBL· GenBank· DDBJ | mRNA | ||
AL136686 EMBL· GenBank· DDBJ | CAB66621.1 EMBL· GenBank· DDBJ | mRNA | ||
AL050345 EMBL· GenBank· DDBJ | CAB43547.1 EMBL· GenBank· DDBJ | mRNA | ||
CR456410 EMBL· GenBank· DDBJ | CAG30296.1 EMBL· GenBank· DDBJ | mRNA | ||
AK311928 EMBL· GenBank· DDBJ | BAG34869.1 EMBL· GenBank· DDBJ | mRNA | ||
AL021707 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471095 EMBL· GenBank· DDBJ | EAW60254.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC016139 EMBL· GenBank· DDBJ | AAH16139.1 EMBL· GenBank· DDBJ | mRNA | ||
AB015347 EMBL· GenBank· DDBJ | BAA88119.1 EMBL· GenBank· DDBJ | mRNA | ||
BK005534 EMBL· GenBank· DDBJ | DAA05582.1 EMBL· GenBank· DDBJ | Genomic DNA |