Q9Y3L5 · RAP2C_HUMAN

  • Protein
    Ras-related protein Rap-2c
  • Gene
    RAP2C
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.

Catalytic activity

Features

Showing features for binding site.

118320406080100120140160180
TypeIDPosition(s)Description
Binding site10-17GTP (UniProtKB | ChEBI)
Binding site57-61GTP (UniProtKB | ChEBI)
Binding site116-119GTP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbicellular tight junction
Cellular Componentcell-cell contact zone
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentextracellular exosome
Cellular Componentplasma membrane
Cellular Componentrecycling endosome membrane
Cellular Componenttertiary granule membrane
Molecular FunctionG protein activity
Molecular FunctionGDP binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functiontranscription coactivator activity
Biological Processestablishment of endothelial intestinal barrier
Biological Processnegative regulation of cell migration
Biological Processpositive regulation of protein autophosphorylation
Biological ProcessRap protein signal transduction
Biological Processregulation of protein tyrosine kinase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ras-related protein Rap-2c
  • EC number

Gene names

    • Name
      RAP2C

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9Y3L5
  • Secondary accessions
    • B3KWD6
    • Q5H9H9
    • Q9BTS0

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 140 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), lipidation, modified residue, propeptide.

TypeIDPosition(s)SourceDescription
ChainPRO_00000302211-180UniProt
Modified residue (large scale data)66PRIDEPhosphoserine
Lipidation176UniProtS-palmitoyl cysteine
Lipidation177UniProtS-palmitoyl cysteine
Modified residue180UniProtCysteine methyl ester
Lipidation180UniProtS-geranylgeranyl cysteine
PropeptidePRO_0000030222181-183UniProtRemoved in mature form

Post-translational modification

Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in liver, skeletal muscle, prostate, uterus, rectum, stomach, and bladder and to a lower extent in brain, kidney, pancreas, and bone marrow. Expressed in mononuclear leukocytes and megakaryocytes.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9Y3L5RAP1GDS1 P52306-53EBI-2856617, EBI-12832744

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif32-40Effector region

Sequence similarities

Belongs to the small GTPase superfamily. Ras family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    183
  • Mass (Da)
    20,745
  • Last updated
    1999-11-01 v1
  • Checksum
    6763385F76638324
MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTCVVQ

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A087X2C3A0A087X2C3_HUMANRAP2C117

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict135in Ref. 6; AAH03403

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY298955
EMBL· GenBank· DDBJ
AAP55684.1
EMBL· GenBank· DDBJ
mRNA
AL049685
EMBL· GenBank· DDBJ
CAB41256.1
EMBL· GenBank· DDBJ
mRNA
AK124801
EMBL· GenBank· DDBJ
BAG54098.1
EMBL· GenBank· DDBJ
mRNA
Z78022
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471107
EMBL· GenBank· DDBJ
EAX11782.1
EMBL· GenBank· DDBJ
Genomic DNA
BC003403
EMBL· GenBank· DDBJ
AAH03403.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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