Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation.Billuart P., Bienvenu T., Ronce N., des Portes V., Vinet M.C., Zemni R., Roest Crollius H., Carrie A., Fauchereau F.[...], Chelly J.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCNature 392:923-926 (1998)Cited in1Mapped to50
MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells.Toure A., Dorseuil O., Morin L., Timmons P., Jegou B., Reibel L., Gacon G.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCJ. Biol. Chem. 273:6019-6023 (1998)Cited in1Mapped to70
Human myosin-IXb is a mechanochemically active motor and a GAP for rho.Post P.L., Bokoch G.M., Mooseker M.S.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCJ. Cell Sci. 111:941-950 (1998)Cited in1Mapped to66
A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1.Saras J., Franzen P., Aspenstroem P., Hellman U., Gonez L.J., Heldin C.-H.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCJ. Biol. Chem. 272:24333-24338 (1997)Cited in2Mapped to64
p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking.Burbelo P.D., Miyamoto S., Utani A., Brill S., Yamada K.M., Hall A., Yamada Y.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCJ. Biol. Chem. 270:30919-30926 (1995)Cited in1Mapped to64
Breakpoint cluster region gene product-related domain of n-chimaerin. Discrimination between Rac-binding and GTPase-activating residues by mutational analysis.Ahmed S., Lee J., Wen L.P., Zhao Z., Ho J., Best A., Kozma R., Lim L.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCJ Biol Chem 269:17642-17648 (1994)Mapped to65
A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activities.Homma Y., Emori Y.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCEMBO J. 14:286-291 (1995)Cited in1Mapped to55
Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity.Jullien-Flores V., Dorseuil O., Romero F., Letourneur F., Saragosti S., Berger R., Tavitian A., Gacon G., Camonis J.H.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCJ. Biol. Chem. 270:22473-22477 (1995)Cited in4Mapped to63
Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.Chuang T.H., Xu X., Kaartinen V., Heisterkamp N., Groffen J., Bokoch G.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 92:10282-10286 (1995)Cited in2Mapped to99+
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.Mueller P.M., Rademacher J., Bagshaw R.D., Wortmann C., Barth C., van Unen J., Alp K.M., Giudice G., Eccles R.L.[...], Rocks O.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCNat. Cell Biol. 22:498-511 (2020)Cited in3Mapped to99+
Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.Bagci H., Sriskandarajah N., Robert A., Boulais J., Elkholi I.E., Tran V., Lin Z.Y., Thibault M.P., Dube N.[...], Cote J.F.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCNat. Cell Biol. 22:120-134 (2020)Cited in2Mapped to99+
RhoGTPase Regulators Orchestrate Distinct Stages of Synaptic Development.Martin-Vilchez S., Whitmore L., Asmussen H., Zareno J., Horwitz R., Newell-Litwa K.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCPLoS One 12:e0170464-e0170464 (2017)Mapped to51
Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits.Zamboni V., Armentano M., Saro G., Ciraolo E., Ghigo A., Germena G., Umbach A., Valnegri P., Passafaro M.[...], Merlo G.R.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCSci Rep 6:34877-34877 (2016)Mapped to91
Rac GTPase Activating Protein ARHGAP25 Regulates Leukocyte Transendothelial Migration in Mice.Csepanyi-Komi R., Wisniewski E., Bartos B., Levai P., Nemeth T., Balazs B., Kurz A.R., Bierschenk S., Sperandio M., Ligeti E.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCJ Immunol 197:2807-2815 (2016)Mapped to53
Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS.Amin E., Jaiswal M., Derewenda U., Reis K., Nouri K., Koessmeier K.T., Aspenstrom P., Somlyo A.V., Dvorsky R., Ahmadian M.R.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCJ Biol Chem 291:20353-20371 (2016)Mapped to76
Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase- Activating Proteins in Basal-like Breast Cancers.Lawson C.D., Fan C., Mitin N., Baker N.M., George S.D., Graham D.M., Perou C.M., Burridge K., Der C.J., Rossman K.L.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCCancer Res 76:3826-3837 (2016)Mapped to75
Oligophrenin1 protects mice against myocardial ischemia and reperfusion injury by modulating inflammation and myocardial apoptosis.Niermann C., Gorressen S., Klier M., Gowert N.S., Billuart P., Kelm M., Merx M.W., Elvers M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCCell Signal 28:967-978 (2016)Mapped to57
Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression.Kong R., Yi F., Wen P., Liu J., Chen X., Ren J., Li X., Shang Y., Nie Y.[...], Wu J.Y.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCJ. Clin. Invest. 125:4407-4420 (2015)Cited in2Mapped to69
Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion.Florio M., Albert M., Taverna E., Namba T., Brandl H., Lewitus E., Haffner C., Sykes A., Wong F.K.[...], Huttner W.B.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCScience 347:1465-1470 (2015)Cited in1Mapped to71
Identification of the GTPase-activating protein DEP domain containing 1B (DEPDC1B) as a transcriptional target of Pitx2.Wu D., Zhu X., Jimenez-Cowell K., Mold A.J., Sollecito C.C., Lombana N., Jiao M., Wei Q.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCExp Cell Res 333:80-92 (2015)Mapped to68
Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers.Yeung C.Y., Taylor S.H., Garva R., Holmes D.F., Zeef L.A., Soininen R., Boot-Handford R.P., Kadler K.E.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCPLoS One 9:e107036-e107036 (2014)Mapped to99+
Arhgap36-dependent activation of Gli transcription factors.Rack P.G., Ni J., Payumo A.Y., Nguyen V., Crapster J.A., Hovestadt V., Kool M., Jones D.T., Mich J.K.[...], Chen J.K.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCProc Natl Acad Sci U S A 111:11061-11066 (2014)Cited in2Mapped to73
Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex.Um K., Niu S., Duman J.G., Cheng J.X., Tu Y.K., Schwechter B., Liu F., Hiles L., Narayanan A.S.[...], Tolias K.F.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCDev Cell 29:701-715 (2014)Mapped to82
ARHGAP22 localizes at endosomes and regulates actin cytoskeleton.Mori M., Saito K., Ohta Y.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCPLoS One 9:e100271-e100271 (2014)Mapped to65
Rho-GTPase-activating protein interacting with Cdc-42-interacting protein 4 homolog 2 (Rich2): a new Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase-activating protein that controls dendritic spine morphogenesis.Raynaud F., Moutin E., Schmidt S., Dahl J., Bertaso F., Boeckers T.M., Homburger V., Fagni L.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-3006458PubMedEurope PMCJ. Biol. Chem. 289:2600-2609 (2014)Cited in4Mapped to72