Q9Y3C1 · NOP16_HUMAN

  • Protein
    Nucleolar protein 16
  • Gene
    NOP16
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentintracellular membrane-bounded organelle
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Molecular FunctionRNA binding
Biological Processribosomal large subunit biogenesis

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nucleolar protein 16
  • Alternative names
    • HBV pre-S2 trans-regulated protein 3

Gene names

    • Name
      NOP16
    • ORF names
      CGI-117, HSPC111

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9Y3C1
  • Secondary accessions
    • B4DV13
    • D6RGD3
    • Q05D05
    • Q6IAI6
    • Q6PIM0
    • Q8IXL5

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 219 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data), cross-link.

TypeIDPosition(s)SourceDescription
ChainPRO_00000508171-178UniProtNucleolar protein 16
Modified residue8UniProtPhosphothreonine
Modified residue16UniProtPhosphoserine
Modified residue (large scale data)16PRIDEPhosphoserine
Cross-link74UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue90UniProtN6-acetyllysine
Modified residue144UniProtPhosphothreonine
Modified residue (large scale data)144PRIDEPhosphothreonine
Cross-link166UniProtIn isoform Q9Y3C1-2; Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link167UniProtIn isoform Q9Y3C1-3; Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue (large scale data)169PRIDEPhosphoserine
Cross-link172UniProtIn isoform Q9Y3C1-2; Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link173UniProtIn isoform Q9Y3C1-3; Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-27Basic residues
Region1-31Disordered

Sequence similarities

Belongs to the NOP16 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q9Y3C1-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    178
  • Mass (Da)
    21,188
  • Last updated
    2006-09-19 v2
  • Checksum
    D9139BE32DA81FC5
MPKAKGKTRRQKFGYSVNRKRLNRNARRKAAPRIECSHIRHAWDHAKSVRQNLAEMGLAVDPNRAVPLRKRKVKAMEVDIEERPKELVRKPYVLNDLEAEASLPEKKGNTLSRDLIDYVRYMVENHGEDYKAMARDEKNYYQDTPKQIRSKINVYKRFYPAEWQDFLDSLQKRKMEVE

Q9Y3C1-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 132-178: AMARDEKNYYQDTPKQIRSKINVYKRFYPAEWQDFLDSLQKRKMEVE → SGKTSSILCRRGRWRWSDWFTSQLPQAEASPGPVKLEPGCKARRCCVAPEELARSHGIRRLHTRAHSPLWGRNCSQRLQFIFIWGFTEKPEPAVFRVGDVNIVCT

Q9Y3C1-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 132-178: AMARDEKNYYQDTPKQIRSKINVYKRFYPAEWQDFLDSLQKRKMEVE → QSGKTSSILCRRGRWRWSDWFTSQLPQAEASPGPVKLEPGCKARRCCVAPEELARSHGIRRLHTHVHTPRSGEGTVLRGSNLYSSGGSRKSQNLLFSGWVM

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
D6RIC3D6RIC3_HUMANNOP16150
D6RC60D6RC60_HUMANNOP1695
A0A087WU10A0A087WU10_HUMANNOP1670
A0A0C4DGU5A0A0C4DGU5_HUMANNOP16231

Sequence caution

The sequence AAH19331.1 differs from that shown. Reason: Frameshift
The sequence BAG62525.1 differs from that shown. Reason: Frameshift
The sequence EAW85085.1 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias, sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Compositional bias1-27Basic residues
Sequence conflict32-33in Ref. 2; AAD34112 and 3; AAF29075
Alternative sequenceVSP_045583132-178in isoform 2
Alternative sequenceVSP_057393132-178in isoform 3
Sequence conflict171In isoform Q9Y3C1-2; in Ref. 4; BAG62525
Sequence conflict178in Ref. 5; CAG33450

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY561704
EMBL· GenBank· DDBJ
AAS66977.1
EMBL· GenBank· DDBJ
mRNA
AF151875
EMBL· GenBank· DDBJ
AAD34112.1
EMBL· GenBank· DDBJ
mRNA
AF161460
EMBL· GenBank· DDBJ
AAF29075.1
EMBL· GenBank· DDBJ
mRNA
AK300883
EMBL· GenBank· DDBJ
BAG62525.1
EMBL· GenBank· DDBJ
mRNA Frameshift
CR457169
EMBL· GenBank· DDBJ
CAG33450.1
EMBL· GenBank· DDBJ
mRNA
AC138956
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF459629
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471195
EMBL· GenBank· DDBJ
EAW85084.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471195
EMBL· GenBank· DDBJ
EAW85085.1
EMBL· GenBank· DDBJ
Genomic DNA Frameshift
BC019331
EMBL· GenBank· DDBJ
AAH19331.1
EMBL· GenBank· DDBJ
mRNA Frameshift
BC032424
EMBL· GenBank· DDBJ
AAH32424.1
EMBL· GenBank· DDBJ
mRNA
BC040106
EMBL· GenBank· DDBJ
AAH40106.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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