Q9Y2T3 · GUAD_HUMAN

  • Protein
    Guanine deaminase
  • Gene
    GDA
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
9.5 μMguanine
kcat is 17.4 sec-1 with guanine as substrate.

Pathway

Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site82Zn2+ (UniProtKB | ChEBI)
Binding site84Zn2+ (UniProtKB | ChEBI)
Binding site84-87substrate
Binding site213-214substrate
Binding site240Zn2+ (UniProtKB | ChEBI)
Binding site240-243substrate
Binding site330substrate
Binding site330Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionguanine deaminase activity
Molecular Functionzinc ion binding
Biological Processallantoin metabolic process
Biological Processamide catabolic process
Biological Processdeoxyguanosine catabolic process
Biological ProcessdGMP catabolic process
Biological ProcessGMP catabolic process
Biological Processguanine catabolic process
Biological Processguanine metabolic process
Biological Processnervous system development
Biological Processnucleobase-containing compound metabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Guanine deaminase
  • EC number
  • Short names
    Guanase; Guanine aminase
  • Alternative names
    • Guanine aminohydrolase (GAH)
    • p51-nedasin

Gene names

    • Name
      GDA
    • Synonyms
      KIAA1258

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9Y2T3
  • Secondary accessions
    • B4DTY5
    • Q5SZC7
    • Q9H335
    • Q9ULG2

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 527 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001222981-454Guanine deaminase
Modified residue453Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Chemistry

Miscellaneous

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q9Y2T3-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    454
  • Mass (Da)
    51,003
  • Last updated
    1999-11-01 v1
  • Checksum
    A45C868E6EEA7380
MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV

Q9Y2T3-2

  • Name
    2
  • Synonyms
    c
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9Y2T3-3

  • Name
    3
  • Synonyms
    a
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 454-454: V → VKETIHLPASSPHPPPFP

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0YDZ7H0YDZ7_HUMANGDA176
Q5SZC3Q5SZC3_HUMANGDA179
Q5SZC5Q5SZC5_HUMANGDA195
Q5SZC6Q5SZC6_HUMANGDA393

Sequence caution

The sequence BAA86572.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0420751-74in isoform 2
Sequence conflict316-318in Ref. 3; AAG40469
Alternative sequenceVSP_042076454in isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF095286
EMBL· GenBank· DDBJ
AAD25978.1
EMBL· GenBank· DDBJ
mRNA
AF019638
EMBL· GenBank· DDBJ
AAF13301.1
EMBL· GenBank· DDBJ
mRNA
AF144745
EMBL· GenBank· DDBJ
AAG40469.1
EMBL· GenBank· DDBJ
mRNA
AB033084
EMBL· GenBank· DDBJ
BAA86572.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK300418
EMBL· GenBank· DDBJ
BAG62147.1
EMBL· GenBank· DDBJ
mRNA
AK315988
EMBL· GenBank· DDBJ
BAH14359.1
EMBL· GenBank· DDBJ
mRNA
AL583829
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL590311
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL135924
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471089
EMBL· GenBank· DDBJ
EAW62529.1
EMBL· GenBank· DDBJ
Genomic DNA
BC053584
EMBL· GenBank· DDBJ
AAH53584.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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