Q9Y2R4 · DDX52_HUMAN
- ProteinProbable ATP-dependent RNA helicase DDX52
- GeneDDX52
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids599 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required for efficient ribosome biogenesis (By similarity).
May control cell cycle progression by regulating translation of mRNAs that contain a terminal oligo pyrimidine (TOP) motif in their 5' UTRs, such as GTPBP4 (By similarity).
May control cell cycle progression by regulating translation of mRNAs that contain a terminal oligo pyrimidine (TOP) motif in their 5' UTRs, such as GTPBP4 (By similarity).
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | nucleolus | |
Cellular Component | nucleoplasm | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA helicase activity | |
Biological Process | maturation of SSU-rRNA |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable ATP-dependent RNA helicase DDX52
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9Y2R4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_060235 | 403 | in dbSNP:rs7216445 | |||
Sequence: V → M |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 652 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000055060 | 1-599 | UniProt | Probable ATP-dependent RNA helicase DDX52 | |||
Sequence: MDVHDLFRRLGAGAKFDTRRFSADAARFQIGKRKYDFDSSEVLQGLDFFGNKKSVPGVCGASQTHQKPQNGEKKEESLTERKREQSKKKRKTMTSEIASQEEGATIQWMSSVEAKIEDKKVQRESKLTSGKLENLRKEKINFLRNKHKIHVQGTDLPDPIATFQQLDQEYKINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQPANKGFRALIISPTRELASQIHRELIKISEGTGFRIHMIHKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPPGIDLASVEWLVVDESDKLFEDGKTGFRDQLASIFLACTSHKVRRAMFSATFAYDVEQWCKLNLDNVISVSIGARNSAVETVEQELLFVGSETGKLLAVRELVKKGFNPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFFTEDDKPLLRSVANVIQQAGCPVPEYIKGFQKLLSKQKKKMIKKPLERESISTTPKCFLEKAKDKQKKVTGQNSKKKVALEDKS | |||||||
Modified residue | 15 | UniProt | N6-acetyllysine | ||||
Sequence: K | |||||||
Modified residue (large scale data) | 22 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 39 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 292 | PRIDE | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for region, compositional bias, motif, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 59-100 | Disordered | ||||
Sequence: CGASQTHQKPQNGEKKEESLTERKREQSKKKRKTMTSEIASQ | ||||||
Compositional bias | 68-96 | Basic and acidic residues | ||||
Sequence: PQNGEKKEESLTERKREQSKKKRKTMTSE | ||||||
Motif | 165-193 | Q motif | ||||
Sequence: QLDQEYKINSRLLQNILDAGFQMPTPIQM | ||||||
Domain | 196-374 | Helicase ATP-binding | ||||
Sequence: IPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQPANKGFRALIISPTRELASQIHRELIKISEGTGFRIHMIHKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPPGIDLASVEWLVVDESDKLFEDGKTGFRDQLASIFLACTSHKVRRAMFSATFAYDVEQWCKLNLDNVISV | ||||||
Motif | 318-321 | DEAD box | ||||
Sequence: DESD | ||||||
Domain | 385-546 | Helicase C-terminal | ||||
Sequence: TVEQELLFVGSETGKLLAVRELVKKGFNPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFFTEDDKPLLRSVANVIQQAGCPVPEYIKGFQ | ||||||
Region | 577-599 | Disordered | ||||
Sequence: AKDKQKKVTGQNSKKKVALEDKS |
Sequence similarities
Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length599
- Mass (Da)67,466
- Last updated2022-02-23 v4
- Checksum0EA504577A8BB7DB
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A087X069 | A0A087X069_HUMAN | DDX52 | 112 | ||
A0A087X121 | A0A087X121_HUMAN | DDX52 | 115 | ||
A0A087X1P7 | A0A087X1P7_HUMAN | DDX52 | 97 | ||
A0A087WTD6 | A0A087WTD6_HUMAN | DDX52 | 101 |
Sequence caution
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 68-96 | Basic and acidic residues | ||||
Sequence: PQNGEKKEESLTERKREQSKKKRKTMTSE | ||||||
Sequence conflict | 299 | in Ref. 2; AK093661 | ||||
Sequence: L → S | ||||||
Sequence conflict | 582 | in Ref. 2; BAA91812 | ||||
Sequence: K → R | ||||||
Sequence conflict | 584 | in Ref. 4; CAA09374 | ||||
Sequence: V → F |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF077033 EMBL· GenBank· DDBJ | AAD27766.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
AK001652 EMBL· GenBank· DDBJ | BAA91812.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AK093661 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
AC091199 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC041785 EMBL· GenBank· DDBJ | AAH41785.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ010840 EMBL· GenBank· DDBJ | CAA09374.1 EMBL· GenBank· DDBJ | mRNA | Frameshift |