Q9Y2R4 · DDX52_HUMAN

  • Protein
    Probable ATP-dependent RNA helicase DDX52
  • Gene
    DDX52
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Required for efficient ribosome biogenesis (By similarity).
May control cell cycle progression by regulating translation of mRNAs that contain a terminal oligo pyrimidine (TOP) motif in their 5' UTRs, such as GTPBP4 (By similarity).

Catalytic activity

Features

Showing features for binding site.

159950100150200250300350400450500550
TypeIDPosition(s)Description
Binding site209-216ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Biological Processmaturation of SSU-rRNA

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable ATP-dependent RNA helicase DDX52
  • EC number
  • Alternative names
    • ATP-dependent RNA helicase ROK1-like
    • DEAD box protein 52

Gene names

    • Name
      DDX52
    • Synonyms
      ROK1
    • ORF names
      HUSSY-19

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9Y2R4
  • Secondary accessions
    • Q86YG1
    • Q8N213
    • Q9NVE0
    • Q9Y482

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_060235403in dbSNP:rs7216445

Variants

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The viewer provides 652 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00000550601-599UniProtProbable ATP-dependent RNA helicase DDX52
Modified residue15UniProtN6-acetyllysine
Modified residue (large scale data)22PRIDEPhosphoserine
Modified residue39UniProtPhosphoserine
Modified residue (large scale data)292PRIDEPhosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias, motif, domain.

TypeIDPosition(s)Description
Region59-100Disordered
Compositional bias68-96Basic and acidic residues
Motif165-193Q motif
Domain196-374Helicase ATP-binding
Motif318-321DEAD box
Domain385-546Helicase C-terminal
Region577-599Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    599
  • Mass (Da)
    67,466
  • Last updated
    2022-02-23 v4
  • Checksum
    0EA504577A8BB7DB
MDVHDLFRRLGAGAKFDTRRFSADAARFQIGKRKYDFDSSEVLQGLDFFGNKKSVPGVCGASQTHQKPQNGEKKEESLTERKREQSKKKRKTMTSEIASQEEGATIQWMSSVEAKIEDKKVQRESKLTSGKLENLRKEKINFLRNKHKIHVQGTDLPDPIATFQQLDQEYKINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQPANKGFRALIISPTRELASQIHRELIKISEGTGFRIHMIHKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPPGIDLASVEWLVVDESDKLFEDGKTGFRDQLASIFLACTSHKVRRAMFSATFAYDVEQWCKLNLDNVISVSIGARNSAVETVEQELLFVGSETGKLLAVRELVKKGFNPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFFTEDDKPLLRSVANVIQQAGCPVPEYIKGFQKLLSKQKKKMIKKPLERESISTTPKCFLEKAKDKQKKVTGQNSKKKVALEDKS

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A087X069A0A087X069_HUMANDDX52112
A0A087X121A0A087X121_HUMANDDX52115
A0A087X1P7A0A087X1P7_HUMANDDX5297
A0A087WTD6A0A087WTD6_HUMANDDX52101

Sequence caution

The sequence AAD27766.1 differs from that shown. Reason: Frameshift
The sequence AK093661 differs from that shown. Reason: Miscellaneous discrepancy Cloning artifact.
The sequence BAA91812.1 differs from that shown. Reason: Miscellaneous discrepancy Cloning artifact.
The sequence CAA09374.1 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias68-96Basic and acidic residues
Sequence conflict299in Ref. 2; AK093661
Sequence conflict582in Ref. 2; BAA91812
Sequence conflict584in Ref. 4; CAA09374

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF077033
EMBL· GenBank· DDBJ
AAD27766.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AK001652
EMBL· GenBank· DDBJ
BAA91812.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AK093661
EMBL· GenBank· DDBJ
-mRNA No translation available.
AC091199
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC041785
EMBL· GenBank· DDBJ
AAH41785.1
EMBL· GenBank· DDBJ
mRNA
AJ010840
EMBL· GenBank· DDBJ
CAA09374.1
EMBL· GenBank· DDBJ
mRNA Frameshift

Genome annotation databases

Similar Proteins

Disclaimer

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