Q9Y2H6 · FND3A_HUMAN

  • Protein
    Fibronectin type-III domain-containing protein 3A
  • Gene
    FNDC3A
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Mediates spermatid-Sertoli adhesion during spermatogenesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentacrosomal vesicle
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular ComponentGolgi apparatus
Cellular ComponentGolgi membrane
Cellular Componentintracellular membrane-bounded organelle
Cellular Componentmembrane
Cellular Componentvesicle membrane
Molecular FunctionRNA binding
Biological Processcell-cell adhesion
Biological Processfertilization
Biological ProcessSertoli cell development
Biological Processspermatid development

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fibronectin type-III domain-containing protein 3A
  • Alternative names
    • Human gene expressed in odontoblasts

Gene names

    • Name
      FNDC3A
    • Synonyms
      FNDC3, HUGO, KIAA0970

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9Y2H6
  • Secondary accessions
    • B4DYG1
    • Q5HYC9
    • Q5JVF8
    • Q5JVF9
    • Q6EVH3

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane1177-1197Helical

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_059655107in dbSNP:rs34539036

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,194 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
ChainPRO_00000873211-1198UniProtFibronectin type-III domain-containing protein 3A
Modified residue (large scale data)114PRIDEPhosphoserine
Modified residue (large scale data)202PRIDEPhosphoserine
Modified residue203UniProtPhosphoserine
Modified residue (large scale data)203PRIDEPhosphoserine
Modified residue (large scale data)206PRIDEPhosphoserine
Modified residue207UniProtPhosphoserine
Modified residue (large scale data)207PRIDEPhosphoserine
Modified residue213UniProtPhosphoserine
Modified residue (large scale data)213PRIDEPhosphoserine
Modified residue (large scale data)234PRIDEPhosphoserine
Modified residue (large scale data)246PRIDEPhosphothreonine
Modified residue384UniProtN6-acetyllysine
Modified residue (large scale data)434PRIDEPhosphoserine
Modified residue (large scale data)963PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the odontoblast and nerves in the dental pulp. Also expressed in trachea and to a lesser extent in the brain, liver, lung and kidney.

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region160-221Disordered
Compositional bias168-198Basic and acidic residues
Domain268-369Fibronectin type-III 1
Domain373-465Fibronectin type-III 2
Domain469-562Fibronectin type-III 3
Domain566-660Fibronectin type-III 4
Domain664-757Fibronectin type-III 5
Domain761-851Fibronectin type-III 6
Domain861-950Fibronectin type-III 7
Domain951-1045Fibronectin type-III 8
Domain1046-1151Fibronectin type-III 9

Sequence similarities

Belongs to the FNDC3 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative promoter usage.

Q9Y2H6-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    HUGO1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    1,198
  • Mass (Da)
    131,852
  • Last updated
    2009-07-28 v4
  • Checksum
    2809E41E89BDD095
MAEHPPLLDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTVLHRSPHPPLPGFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRDERSSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAKIKSGKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPPASTNRDTVESTRTRRALSDEQCAAVILVLFAFFSILIAFIIQYFVIK

Q9Y2H6-2

  • Name
    2
  • Synonyms
    HUGO2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H7C507H7C507_HUMANFNDC3A139
G5E9X3G5E9X3_HUMANFNDC3A684
A0A087X1M6A0A087X1M6_HUMANFNDC3A326

Sequence caution

The sequence BAA76814.2 differs from that shown. Reason: Erroneous initiation
The sequence BAD18784.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0377231-56in isoform 2
Sequence conflict53in Ref. 5; CAI45989
Alternative sequenceVSP_03772457-58in isoform 2
Compositional bias168-198Basic and acidic residues
Sequence conflict350in Ref. 5; CAE45852
Sequence conflict501in Ref. 5; CAE45852
Sequence conflict839in Ref. 8; AAH60816/AAH70072

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ749706
EMBL· GenBank· DDBJ
CAG44602.1
EMBL· GenBank· DDBJ
mRNA
AJ749707
EMBL· GenBank· DDBJ
CAG44603.1
EMBL· GenBank· DDBJ
mRNA
AB023187
EMBL· GenBank· DDBJ
BAA76814.2
EMBL· GenBank· DDBJ
mRNA Different initiation
AK172814
EMBL· GenBank· DDBJ
BAD18784.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK302415
EMBL· GenBank· DDBJ
BAG63723.1
EMBL· GenBank· DDBJ
mRNA
BX640739
EMBL· GenBank· DDBJ
CAE45852.1
EMBL· GenBank· DDBJ
mRNA
BX648141
EMBL· GenBank· DDBJ
CAI45989.1
EMBL· GenBank· DDBJ
mRNA
AL161421
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL359184
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL137000
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471075
EMBL· GenBank· DDBJ
EAX08804.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471075
EMBL· GenBank· DDBJ
EAX08806.1
EMBL· GenBank· DDBJ
Genomic DNA
BC060816
EMBL· GenBank· DDBJ
AAH60816.1
EMBL· GenBank· DDBJ
mRNA
BC070072
EMBL· GenBank· DDBJ
AAH70072.1
EMBL· GenBank· DDBJ
mRNA
BC132812
EMBL· GenBank· DDBJ
AAI32813.1
EMBL· GenBank· DDBJ
mRNA
BC136617
EMBL· GenBank· DDBJ
AAI36618.1
EMBL· GenBank· DDBJ
mRNA
BC144301
EMBL· GenBank· DDBJ
AAI44302.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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