Q9Y2H5 · PKHA6_HUMAN
- ProteinPleckstrin homology domain-containing family A member 6
- GenePLEKHA6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1048 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePleckstrin homology domain-containing family A member 6
- Short namesPH domain-containing family A member 6
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9Y2H5
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_037145 | 43 | in dbSNP:rs10900571 | |||
Sequence: V → I | ||||||
Natural variant | VAR_037146 | 837 | in dbSNP:rs10900562 | |||
Sequence: R → K |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,289 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000053884 | 1-1048 | UniProt | Pleckstrin homology domain-containing family A member 6 | |||
Sequence: MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKEPPVKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGGGPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSPSQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSPKVPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNEPKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAEKQAALNKVGVVPPRTKSPTDDEVTPSAVVRRNASGLTNGLSSQERPKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMREKRRSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPPANPLSSESPRGADSSYTMRV | |||||||
Modified residue (large scale data) | 197 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 247 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 247 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 251 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 251 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 276 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 282 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 287 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 314 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 314 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 336 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 338 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 362 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 384 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 426 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 443 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 448 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 453 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 455 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 459 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 459 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 461 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 461 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 472 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 472 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 476 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 478 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 488 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 492 | UniProt | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 492 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 498 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 505 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 591 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 591 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 744 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 775 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 777 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 777 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 779 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 784 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 784 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 794 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 801 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 808 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 842 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 848 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 848 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 854 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 854 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 867 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 867 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 890 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 919 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 920 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 920 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 940 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 940 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1015 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 1015 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 1017 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1017 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1020 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 1020 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 1021 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1024 | UniProt | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in heart, kidney and throughout the brain.
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9Y2H5 | UBE2Z Q9H832 | 3 | EBI-1171228, EBI-720977 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-21 | Polar residues | ||||
Sequence: MSNKTGGKRPATTNSDIPNHN | ||||||
Region | 1-36 | Disordered | ||||
Sequence: MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRAT | ||||||
Domain | 59-158 | PH | ||||
Sequence: PVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAAR | ||||||
Region | 165-318 | Disordered | ||||
Sequence: QKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKEPPVKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQL | ||||||
Compositional bias | 171-185 | Basic and acidic residues | ||||
Sequence: AVRHSHEKPDSENVP | ||||||
Compositional bias | 201-232 | Basic and acidic residues | ||||
Sequence: PEPEAKTRGEGDGRGCEKAERRPERPEVKKEP | ||||||
Compositional bias | 269-289 | Polar residues | ||||
Sequence: PNGWQYHSPSRPGSTAFPSQD | ||||||
Region | 448-467 | Disordered | ||||
Sequence: SLQPRSHSVPRSPSQGSYSR | ||||||
Region | 663-746 | Disordered | ||||
Sequence: RKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNEPKANYEQSKKDPHQTLPLDTPR | ||||||
Compositional bias | 682-727 | Polar residues | ||||
Sequence: PSATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNEPKA | ||||||
Region | 793-858 | Disordered | ||||
Sequence: ASGLTNGLSSQERPKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMREKRRSLQLPASPAPDPSPRPA | ||||||
Compositional bias | 819-833 | Basic and acidic residues | ||||
Sequence: MSVEEQIDRMRRHQS | ||||||
Region | 968-989 | Disordered | ||||
Sequence: PIGEGDSVDVPQDSESQLQEQE | ||||||
Region | 1005-1048 | Disordered | ||||
Sequence: RGRMLSVQCATPSPPTSPASPAPPANPLSSESPRGADSSYTMRV | ||||||
Compositional bias | 1018-1032 | Pro residues | ||||
Sequence: PPTSPASPAPPANPL |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,048
- Mass (Da)117,128
- Last updated2007-11-13 v4
- Checksum230F7CB49C9DDF32
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0AAQ5BGL2 | A0AAQ5BGL2_HUMAN | PLEKHA6 | 1027 | ||
A0A1B0GUN5 | A0A1B0GUN5_HUMAN | PLEKHA6 | 1172 | ||
A0A1B0GW03 | A0A1B0GW03_HUMAN | PLEKHA6 | 138 | ||
A0A5F9ZH45 | A0A5F9ZH45_HUMAN | PLEKHA6 | 377 | ||
Q5VTI5 | Q5VTI5_HUMAN | PLEKHA6 | 1068 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-21 | Polar residues | ||||
Sequence: MSNKTGGKRPATTNSDIPNHN | ||||||
Compositional bias | 171-185 | Basic and acidic residues | ||||
Sequence: AVRHSHEKPDSENVP | ||||||
Compositional bias | 201-232 | Basic and acidic residues | ||||
Sequence: PEPEAKTRGEGDGRGCEKAERRPERPEVKKEP | ||||||
Compositional bias | 269-289 | Polar residues | ||||
Sequence: PNGWQYHSPSRPGSTAFPSQD | ||||||
Compositional bias | 682-727 | Polar residues | ||||
Sequence: PSATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNEPKA | ||||||
Compositional bias | 819-833 | Basic and acidic residues | ||||
Sequence: MSVEEQIDRMRRHQS | ||||||
Compositional bias | 1018-1032 | Pro residues | ||||
Sequence: PPTSPASPAPPANPL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB023186 EMBL· GenBank· DDBJ | BAA76813.2 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AL592114 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC152475 EMBL· GenBank· DDBJ | AAI52476.1 EMBL· GenBank· DDBJ | mRNA |