Q9Y222 · DMTF1_HUMAN
- ProteinCyclin-D-binding Myb-like transcription factor 1
- GeneDMTF1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids760 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity).
Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity).
Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.
Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity).
Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 306-329 | H-T-H motif | ||||
Sequence: WAAVAERVGTRSEKQCRSKWLNYL |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCyclin-D-binding Myb-like transcription factor 1
- Short nameshDMTF1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9Y222
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_039577 | 479 | in dbSNP:rs1558049 | |||
Sequence: V → I |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 756 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000323729 | 1-760 | UniProt | Cyclin-D-binding Myb-like transcription factor 1 | |||
Sequence: MSTVEEDSDTVTVETVNSVTLTQDTEGNLILHCPQNEADEIDSEDSIEPPHKRLCLSSEDDQSIDDSTPCISVVALPLSENDQSFEVTMTATTEVADDEVTEGTVTQIQILQNEQLDEISPLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSKEEIDILMNNIERYLKARGIKDATEIIFEMSKDERKDFYRTIAWGLNRPLFAVYRRVLRMYDDRNHVGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMKDTCNTGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYLNWKQSGGTEWTKEDEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWLRSKWWTIKRQIANHKDVSFPVLIKGLKQLHENQKNNPTLLENKSGSGVPNSNTNSSVQHVQIRVARLEDNTAISSSPMAALQIPVQITHVSSADSPATVDSETITLNSGTLQTFEILPSFHLQPTGTPGTYLLQTSSSQGLPLTLTASPTVTLTAAAPASPEQIIVHALSPEHLLNTSDNVTVQCHTPRVIIQTVATEDITSSISQAELTVDSDIQSSDFPEPPDALEADTFPDEIHHPKMTVEPSFNDAHVSKFSDQNSTELMNSVMVRTEEEISDTDLKQEESPSDLASAYVTEGLESPTIEEQVDQTIDDETILIVPSPHGFIQASDVIDTESVLPLTTLTDPILQHHQEESNIIGSSLGSPVSEDSKDVEDLVNCH | |||||||
Modified residue (large scale data) | 656 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 701 | PRIDE | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin-D2/CDK6 complexes and to a lesser extent by the cyclin-D1/CDK4 complex.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed at relatively low levels in colonic mucosa, ovary, peripheral leukocytes, prostate and small intestine, and at higher levels in spleen, testis and thymus. Expressed in multiple regions of the brain and CNS including amygdala, caudate, corpus callosum, hippocampus, substantia nigra and subthalamic nucleus. Isoform 1 is the predominant isoform in monocytes, macrophages and neutrophils, isoform 2 is most strongly expressed in peripheral blood leukocytes and quiescent CD34 positive cells, and isoform 3 is expressed at low levels in all hematopoietic cell types. Expression is frequently reduced in non-small-cell lung carcinomas (NSCLC) due to hemizygous gene deletion, strongly suggesting that this locus is haploinsufficient for tumor suppression. Loss of this locus frequently occurs in tumors which retain wild-type CDKN2A/ARF and p53/TP53 loci. Hemizygous gene deletion has also been observed in leukemic blasts from patients with abnormalities of the long arm of chromosome 7.
Developmental stage
Isoform 2 expression is down-regulated during myeloid differentiation, while the expression of isoform 1 and isoform 3 remain constant.
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-237 | Interaction with CCND2 | ||||
Sequence: MSTVEEDSDTVTVETVNSVTLTQDTEGNLILHCPQNEADEIDSEDSIEPPHKRLCLSSEDDQSIDDSTPCISVVALPLSENDQSFEVTMTATTEVADDEVTEGTVTQIQILQNEQLDEISPLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSKEEIDILMNNIERYLKARGIKDATEIIFEMSKDERKDFYRTIAWGLNRPLFAVYRRVLRMYDDRNHVGKYTPEEIEKLKE | ||||||
Region | 87-170 | Required for transcriptional activation | ||||
Sequence: VTMTATTEVADDEVTEGTVTQIQILQNEQLDEISPLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSKEEIDILMNNIER | ||||||
Region | 87-458 | Required for DNA-binding | ||||
Sequence: VTMTATTEVADDEVTEGTVTQIQILQNEQLDEISPLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSKEEIDILMNNIERYLKARGIKDATEIIFEMSKDERKDFYRTIAWGLNRPLFAVYRRVLRMYDDRNHVGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMKDTCNTGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYLNWKQSGGTEWTKEDEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWLRSKWWTIKRQIANHKDVSFPVLIKGLKQLHENQKNNPTLLENKSGSGVPNSNTNSSVQHVQIRVARLEDNTAISSSPM | ||||||
Region | 176-760 | Interaction with CCND1, CCND2 and CCND3 | ||||
Sequence: GIKDATEIIFEMSKDERKDFYRTIAWGLNRPLFAVYRRVLRMYDDRNHVGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMKDTCNTGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYLNWKQSGGTEWTKEDEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWLRSKWWTIKRQIANHKDVSFPVLIKGLKQLHENQKNNPTLLENKSGSGVPNSNTNSSVQHVQIRVARLEDNTAISSSPMAALQIPVQITHVSSADSPATVDSETITLNSGTLQTFEILPSFHLQPTGTPGTYLLQTSSSQGLPLTLTASPTVTLTAAAPASPEQIIVHALSPEHLLNTSDNVTVQCHTPRVIIQTVATEDITSSISQAELTVDSDIQSSDFPEPPDALEADTFPDEIHHPKMTVEPSFNDAHVSKFSDQNSTELMNSVMVRTEEEISDTDLKQEESPSDLASAYVTEGLESPTIEEQVDQTIDDETILIVPSPHGFIQASDVIDTESVLPLTTLTDPILQHHQEESNIIGSSLGSPVSEDSKDVEDLVNCH | ||||||
Domain | 225-263 | Myb-like 1 | ||||
Sequence: GKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDR | ||||||
Domain | 268-333 | HTH myb-type | ||||
Sequence: KDTCNTGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYLNWKQ | ||||||
Domain | 339-388 | Myb-like 2 | ||||
Sequence: WTKEDEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWLRSKWWTIK | ||||||
Region | 414-435 | Disordered | ||||
Sequence: KNNPTLLENKSGSGVPNSNTNS | ||||||
Region | 459-760 | Required for transcriptional activation | ||||
Sequence: AALQIPVQITHVSSADSPATVDSETITLNSGTLQTFEILPSFHLQPTGTPGTYLLQTSSSQGLPLTLTASPTVTLTAAAPASPEQIIVHALSPEHLLNTSDNVTVQCHTPRVIIQTVATEDITSSISQAELTVDSDIQSSDFPEPPDALEADTFPDEIHHPKMTVEPSFNDAHVSKFSDQNSTELMNSVMVRTEEEISDTDLKQEESPSDLASAYVTEGLESPTIEEQVDQTIDDETILIVPSPHGFIQASDVIDTESVLPLTTLTDPILQHHQEESNIIGSSLGSPVSEDSKDVEDLVNCH | ||||||
Region | 738-760 | Disordered | ||||
Sequence: IGSSLGSPVSEDSKDVEDLVNCH |
Sequence similarities
Belongs to the DMTF1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing.
Q9Y222-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsAlpha
- Length760
- Mass (Da)84,471
- Last updated1999-11-01 v1
- Checksum57B3AE332F21A333
Q9Y222-2
- Name2
- SynonymsBeta
Q9Y222-3
- Name3
- SynonymsGamma
Q9Y222-4
- Name4
Q9Y222-5
- Name5
- Differences from canonical
- 1-88: Missing
Computationally mapped potential isoform sequences
There are 18 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
C9J8Y5 | C9J8Y5_HUMAN | DMTF1 | 90 | ||
J3KRC1 | J3KRC1_HUMAN | DMTF1 | 34 | ||
C9J4F7 | C9J4F7_HUMAN | DMTF1 | 49 | ||
E7EPA0 | E7EPA0_HUMAN | DMTF1 | 690 | ||
C9JZZ6 | C9JZZ6_HUMAN | DMTF1 | 136 | ||
C9JVQ7 | C9JVQ7_HUMAN | DMTF1 | 96 | ||
F8VXY9 | F8VXY9_HUMAN | DMTF1 | 378 | ||
C9K0K9 | C9K0K9_HUMAN | DMTF1 | 27 | ||
C9K0L9 | C9K0L9_HUMAN | DMTF1 | 85 | ||
C9JLR5 | C9JLR5_HUMAN | DMTF1 | 40 | ||
C9JGT5 | C9JGT5_HUMAN | DMTF1 | 175 | ||
C9JFR2 | C9JFR2_HUMAN | DMTF1 | 191 | ||
C9JED5 | C9JED5_HUMAN | DMTF1 | 73 | ||
H7C388 | H7C388_HUMAN | DMTF1 | 176 | ||
J3QKU5 | J3QKU5_HUMAN | DMTF1 | 178 | ||
J3QLN9 | J3QLN9_HUMAN | DMTF1 | 365 | ||
J3QLW3 | J3QLW3_HUMAN | DMTF1 | 16 | ||
A0A1D5RMP8 | A0A1D5RMP8_HUMAN | DMTF1 | 10 |
Sequence caution
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_041063 | 1-88 | in isoform 5 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_032089 | 37-78 | in isoform 4 | |||
Sequence: EADEIDSEDSIEPPHKRLCLSSEDDQSIDDSTPCISVVALPL → V | ||||||
Alternative sequence | VSP_032091 | 238-273 | in isoform 2 | |||
Sequence: LRIKHGNDWATIGAALGRSASSVKDRCRLMKDTCNT → QLWTPKKGHTFKLWLSKYCCPQLPNQSNGKKKNEE | ||||||
Alternative sequence | VSP_032090 | 238-285 | in isoform 3 and isoform 4 | |||
Sequence: LRIKHGNDWATIGAALGRSASSVKDRCRLMKDTCNTGKWTEEEEKRLA → KKAIAACFFFTHRQLWTPKKGHTFKLWLSKYCCPQLPNQSNGKKKNEE | ||||||
Alternative sequence | VSP_032092 | 274-760 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_032093 | 286-760 | in isoform 3 and isoform 4 | |||
Sequence: Missing | ||||||
Sequence conflict | 345 | in Ref. 3; BAG58937 | ||||
Sequence: I → T | ||||||
Sequence conflict | 616 | in Ref. 7; AAH70064 | ||||
Sequence: I → V |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF084530 EMBL· GenBank· DDBJ | AAC33480.1 EMBL· GenBank· DDBJ | mRNA | ||
AF202144 EMBL· GenBank· DDBJ | AAG35613.1 EMBL· GenBank· DDBJ | mRNA | ||
AF202145 EMBL· GenBank· DDBJ | AAG35614.1 EMBL· GenBank· DDBJ | mRNA | ||
AK296211 EMBL· GenBank· DDBJ | BAG58937.1 EMBL· GenBank· DDBJ | mRNA | ||
AK126664 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
AK314622 EMBL· GenBank· DDBJ | BAG37188.1 EMBL· GenBank· DDBJ | mRNA | ||
AB209230 EMBL· GenBank· DDBJ | BAD92467.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AC005076 EMBL· GenBank· DDBJ | AAD43181.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471091 EMBL· GenBank· DDBJ | EAW76963.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC007418 EMBL· GenBank· DDBJ | AAH07418.2 EMBL· GenBank· DDBJ | mRNA | ||
BC007447 EMBL· GenBank· DDBJ | AAH07447.2 EMBL· GenBank· DDBJ | mRNA | ||
BC029370 EMBL· GenBank· DDBJ | AAH29370.1 EMBL· GenBank· DDBJ | mRNA | Different termination. | |
BC070064 EMBL· GenBank· DDBJ | AAH70064.1 EMBL· GenBank· DDBJ | mRNA |