Q9Y222 · DMTF1_HUMAN

  • Protein
    Cyclin-D-binding Myb-like transcription factor 1
  • Gene
    DMTF1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity).
Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity).
Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.

Features

Showing features for dna binding.

1760100200300400500600700
TypeIDPosition(s)Description
DNA binding306-329H-T-H motif

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processregulation of DNA-templated transcription
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cyclin-D-binding Myb-like transcription factor 1
  • Short names
    hDMTF1
  • Alternative names
    • Cyclin-D-interacting Myb-like protein 1 (hDMP1)

Gene names

    • Name
      DMTF1
    • Synonyms
      DMP1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9Y222
  • Secondary accessions
    • B2RBE1
    • B4DJS5
    • Q05C48
    • Q59G79
    • Q6IS13

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_039577479in dbSNP:rs1558049

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 756 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00003237291-760UniProtCyclin-D-binding Myb-like transcription factor 1
Modified residue (large scale data)656PRIDEPhosphoserine
Modified residue (large scale data)701PRIDEPhosphoserine

Post-translational modification

Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin-D2/CDK6 complexes and to a lesser extent by the cyclin-D1/CDK4 complex.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed at relatively low levels in colonic mucosa, ovary, peripheral leukocytes, prostate and small intestine, and at higher levels in spleen, testis and thymus. Expressed in multiple regions of the brain and CNS including amygdala, caudate, corpus callosum, hippocampus, substantia nigra and subthalamic nucleus. Isoform 1 is the predominant isoform in monocytes, macrophages and neutrophils, isoform 2 is most strongly expressed in peripheral blood leukocytes and quiescent CD34 positive cells, and isoform 3 is expressed at low levels in all hematopoietic cell types. Expression is frequently reduced in non-small-cell lung carcinomas (NSCLC) due to hemizygous gene deletion, strongly suggesting that this locus is haploinsufficient for tumor suppression. Loss of this locus frequently occurs in tumors which retain wild-type CDKN2A/ARF and p53/TP53 loci. Hemizygous gene deletion has also been observed in leukemic blasts from patients with abnormalities of the long arm of chromosome 7.

Developmental stage

Isoform 2 expression is down-regulated during myeloid differentiation, while the expression of isoform 1 and isoform 3 remain constant.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with the D-type cyclins CCND1, CCND2 and CCND3. Interaction with D-type cyclins may modulate transcriptional activation by this protein.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-237Interaction with CCND2
Region87-170Required for transcriptional activation
Region87-458Required for DNA-binding
Region176-760Interaction with CCND1, CCND2 and CCND3
Domain225-263Myb-like 1
Domain268-333HTH myb-type
Domain339-388Myb-like 2
Region414-435Disordered
Region459-760Required for transcriptional activation
Region738-760Disordered

Sequence similarities

Belongs to the DMTF1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (5)
  • Sequence status
    Complete

This entry describes 5 isoforms produced by Alternative splicing.

Q9Y222-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    Alpha
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    760
  • Mass (Da)
    84,471
  • Last updated
    1999-11-01 v1
  • Checksum
    57B3AE332F21A333
MSTVEEDSDTVTVETVNSVTLTQDTEGNLILHCPQNEADEIDSEDSIEPPHKRLCLSSEDDQSIDDSTPCISVVALPLSENDQSFEVTMTATTEVADDEVTEGTVTQIQILQNEQLDEISPLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSKEEIDILMNNIERYLKARGIKDATEIIFEMSKDERKDFYRTIAWGLNRPLFAVYRRVLRMYDDRNHVGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMKDTCNTGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYLNWKQSGGTEWTKEDEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWLRSKWWTIKRQIANHKDVSFPVLIKGLKQLHENQKNNPTLLENKSGSGVPNSNTNSSVQHVQIRVARLEDNTAISSSPMAALQIPVQITHVSSADSPATVDSETITLNSGTLQTFEILPSFHLQPTGTPGTYLLQTSSSQGLPLTLTASPTVTLTAAAPASPEQIIVHALSPEHLLNTSDNVTVQCHTPRVIIQTVATEDITSSISQAELTVDSDIQSSDFPEPPDALEADTFPDEIHHPKMTVEPSFNDAHVSKFSDQNSTELMNSVMVRTEEEISDTDLKQEESPSDLASAYVTEGLESPTIEEQVDQTIDDETILIVPSPHGFIQASDVIDTESVLPLTTLTDPILQHHQEESNIIGSSLGSPVSEDSKDVEDLVNCH

Q9Y222-2

  • Name
    2
  • Synonyms
    Beta
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 238-273: LRIKHGNDWATIGAALGRSASSVKDRCRLMKDTCNT → QLWTPKKGHTFKLWLSKYCCPQLPNQSNGKKKNEE
    • 274-760: Missing

Q9Y222-3

  • Name
    3
  • Synonyms
    Gamma
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 238-285: LRIKHGNDWATIGAALGRSASSVKDRCRLMKDTCNTGKWTEEEEKRLA → KKAIAACFFFTHRQLWTPKKGHTFKLWLSKYCCPQLPNQSNGKKKNEE
    • 286-760: Missing

Q9Y222-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 37-78: EADEIDSEDSIEPPHKRLCLSSEDDQSIDDSTPCISVVALPL → V
    • 238-285: LRIKHGNDWATIGAALGRSASSVKDRCRLMKDTCNTGKWTEEEEKRLA → KKAIAACFFFTHRQLWTPKKGHTFKLWLSKYCCPQLPNQSNGKKKNEE
    • 286-760: Missing

Q9Y222-5

  • Name
    5
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 18 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
C9J8Y5C9J8Y5_HUMANDMTF190
J3KRC1J3KRC1_HUMANDMTF134
C9J4F7C9J4F7_HUMANDMTF149
E7EPA0E7EPA0_HUMANDMTF1690
C9JZZ6C9JZZ6_HUMANDMTF1136
C9JVQ7C9JVQ7_HUMANDMTF196
F8VXY9F8VXY9_HUMANDMTF1378
C9K0K9C9K0K9_HUMANDMTF127
C9K0L9C9K0L9_HUMANDMTF185
C9JLR5C9JLR5_HUMANDMTF140
C9JGT5C9JGT5_HUMANDMTF1175
C9JFR2C9JFR2_HUMANDMTF1191
C9JED5C9JED5_HUMANDMTF173
H7C388H7C388_HUMANDMTF1176
J3QKU5J3QKU5_HUMANDMTF1178
J3QLN9J3QLN9_HUMANDMTF1365
J3QLW3J3QLW3_HUMANDMTF116
A0A1D5RMP8A0A1D5RMP8_HUMANDMTF110

Sequence caution

The sequence BAD92467.1 differs from that shown. Reason: Erroneous translation Wrong choice of frame.

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0410631-88in isoform 5
Alternative sequenceVSP_03208937-78in isoform 4
Alternative sequenceVSP_032091238-273in isoform 2
Alternative sequenceVSP_032090238-285in isoform 3 and isoform 4
Alternative sequenceVSP_032092274-760in isoform 2
Alternative sequenceVSP_032093286-760in isoform 3 and isoform 4
Sequence conflict345in Ref. 3; BAG58937
Sequence conflict616in Ref. 7; AAH70064

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF084530
EMBL· GenBank· DDBJ
AAC33480.1
EMBL· GenBank· DDBJ
mRNA
AF202144
EMBL· GenBank· DDBJ
AAG35613.1
EMBL· GenBank· DDBJ
mRNA
AF202145
EMBL· GenBank· DDBJ
AAG35614.1
EMBL· GenBank· DDBJ
mRNA
AK296211
EMBL· GenBank· DDBJ
BAG58937.1
EMBL· GenBank· DDBJ
mRNA
AK126664
EMBL· GenBank· DDBJ
-mRNA No translation available.
AK314622
EMBL· GenBank· DDBJ
BAG37188.1
EMBL· GenBank· DDBJ
mRNA
AB209230
EMBL· GenBank· DDBJ
BAD92467.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AC005076
EMBL· GenBank· DDBJ
AAD43181.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471091
EMBL· GenBank· DDBJ
EAW76963.1
EMBL· GenBank· DDBJ
Genomic DNA
BC007418
EMBL· GenBank· DDBJ
AAH07418.2
EMBL· GenBank· DDBJ
mRNA
BC007447
EMBL· GenBank· DDBJ
AAH07447.2
EMBL· GenBank· DDBJ
mRNA
BC029370
EMBL· GenBank· DDBJ
AAH29370.1
EMBL· GenBank· DDBJ
mRNA Different termination.
BC070064
EMBL· GenBank· DDBJ
AAH70064.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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