Q9XZI6 · PICAL_CAEEL
- ProteinPhosphatidylinositol-binding clathrin assembly protein unc-11
- Geneunc-11
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids586 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Required for the efficient targeting of the synaptic vesicle protein synaptobrevin.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylinositol-binding clathrin assembly protein unc-11
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ9XZI6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Colocalized with clathrin in the Golgi area.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000187065 | 1-586 | Phosphatidylinositol-binding clathrin assembly protein unc-11 | |||
Sequence: MQTIEKALHQPMPFTTGGQTISDRLTAAKHSLAGSQLGKTICKATTEEVMAPKKKHLDYLLHCTNEPNVSIPSMANLLIERTQNPNWTVVYKALITIHNIMCYGNERFSQYLASCNTTFNLTAFVDKVGGAGGYDMSTHVRRYAKYIGEKINTYRMCAFDFCKVKRGREDGLLRTMHTDKLLKTIPILQNQIDALLEFSVTTSELNNGVINCSFILLFRDLIRLFACYNDGIINVLEKYFDMNKKQCRDALDTYKSFLTRLDKVAEFLRVAESVGIDRGEIPDLTRAPASLLEALEAHLIHLEGGKAPPPTQQHVAPHQFTTGFAFSQQPQPALGDAERQRYIELEQERLRQFEDQKKSINSANPFANDVASAAPAPATSAAQPDLLDMFQSSAAPAPQTADVTNPFGNFAAPSAFPTNVPPPAAHSAPFGVQPAPQHSAAPFYANLHQAPPMQSQAPNGHQAAPFGYPNAHPDDLARMTAQMSLNQQGAPAGWNTTTSAVSNNPFGATSAPQPMYTAPMGMYQQPFGAQPMWNPAMAAYGQQYGYGQPVPPQQQHQIQLVHAAMAAKNAAQAQQAQAASADPFGL |
Proteomic databases
PTM databases
Expression
Tissue specificity
High levels in the nervous system and at lower levels in other tissues. In neurons, enriched at presynaptic terminals and is also present in cell bodies.
Gene expression databases
Interaction
Subunit
Binds clathrin and phosphatidylinositol 4,5-bisphosphate.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9XZI6 | eya-1 O17670 | 4 | EBI-311866, EBI-311862 | |
BINARY | Q9XZI6 | itsn-1 Q9U2T9 | 3 | EBI-311866, EBI-2414252 | |
BINARY | Q9XZI6 | magu-1 Q95XW5 | 3 | EBI-311866, EBI-2317194 | |
BINARY | Q9XZI6 | sorb-1 G5EC32 | 3 | EBI-311866, EBI-325337 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 29-161 | ENTH | ||||
Sequence: KHSLAGSQLGKTICKATTEEVMAPKKKHLDYLLHCTNEPNVSIPSMANLLIERTQNPNWTVVYKALITIHNIMCYGNERFSQYLASCNTTFNLTAFVDKVGGAGGYDMSTHVRRYAKYIGEKINTYRMCAFDF | ||||||
Region | 450-474 | Disordered | ||||
Sequence: APPMQSQAPNGHQAAPFGYPNAHPD |
Sequence similarities
Belongs to the PICALM/SNAP91 family.
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 9 isoforms produced by Alternative splicing.
Q9XZI6-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameA
- Synonymsa
- Length586
- Mass (Da)64,064
- Last updated1999-11-01 v1
- Checksum6E337A81D302DD81
Q9XZI6-2
- NameB
- Synonymsh
Q9XZI6-3
- NameC
- Synonymsb
- Differences from canonical
- 419-458: Missing
Q9XZI6-7
- Namec
- Differences from canonical
- 459-459: N → NEPENPFITAPAAPQMHNAPPVPPPPASQGAPAPINPFADPSATAASSAQPFGDPDDFKFEQKNVKIKILIP
Q9XZI6-4
- NameD
Q9XZI6-8
- Named
Q9XZI6-5
- NameE
- Differences from canonical
- 383-512: Missing
Q9XZI6-9
- Namee
Q9XZI6-6
- Namef
- Differences from canonical
- 1-388: Missing
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_050679 | 1-388 | in isoform f | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_020098 | 383-467 | in isoform e | |||
Sequence: QPDLLDMFQSSAAPAPQTADVTNPFGNFAAPSAFPTNVPPPAAHSAPFGVQPAPQHSAAPFYANLHQAPPMQSQAPNGHQAAPFG → HQCIRLQWECINNHLVLSQCGILRWQHTVNNMDTDNLFHHNSNTKFNWFMQRWLQRTLHKLNRPRPPQPIHLDYSLVVYFSLSLS | ||||||
Alternative sequence | VSP_050680 | 383-512 | in isoform E | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_020099 | 397-408 | in isoform d | |||
Sequence: APQTADVTNPFG → LLQCNRKLQMVS | ||||||
Alternative sequence | VSP_050681 | 397-449 | in isoform D | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_020100 | 409-460 | in isoform d | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_050682 | 419-458 | in isoform C and isoform B | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_020101 | 459 | in isoform c | |||
Sequence: N → NEPENPFITAPAAPQMHNAPPVPPPPASQGAPAPINPFADPSATAASSAQPFGDPDDFKFEQKNVKIKILIP | ||||||
Alternative sequence | VSP_020102 | 468-586 | in isoform e | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_050683 | 489 | in isoform B and isoform D | |||
Sequence: G → GYR |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF144257 EMBL· GenBank· DDBJ | AAD37365.1 EMBL· GenBank· DDBJ | mRNA | ||
AF144258 EMBL· GenBank· DDBJ | AAD37366.1 EMBL· GenBank· DDBJ | mRNA | ||
AF144259 EMBL· GenBank· DDBJ | AAD37367.1 EMBL· GenBank· DDBJ | mRNA | ||
AF144260 EMBL· GenBank· DDBJ | AAD37368.1 EMBL· GenBank· DDBJ | mRNA | ||
AF144261 EMBL· GenBank· DDBJ | AAD37369.1 EMBL· GenBank· DDBJ | mRNA | ||
AF144262 EMBL· GenBank· DDBJ | AAD37370.1 EMBL· GenBank· DDBJ | mRNA | ||
FO080749 EMBL· GenBank· DDBJ | CCD66409.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO080749 EMBL· GenBank· DDBJ | CCD66410.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO080749 EMBL· GenBank· DDBJ | CCD66411.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO080749 EMBL· GenBank· DDBJ | CCD66412.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO080749 EMBL· GenBank· DDBJ | CCD66413.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO080749 EMBL· GenBank· DDBJ | CCD66414.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO080749 EMBL· GenBank· DDBJ | CCD66415.1 EMBL· GenBank· DDBJ | Genomic DNA |