Q9XZI6 · PICAL_CAEEL

  • Protein
    Phosphatidylinositol-binding clathrin assembly protein unc-11
  • Gene
    unc-11
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Required for the efficient targeting of the synaptic vesicle protein synaptobrevin.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentclathrin-coated pit
Cellular Componentclathrin-coated vesicle
Cellular Componentextrinsic component of presynaptic endocytic zone membrane
Cellular ComponentGolgi apparatus
Cellular Componentpresynaptic membrane
Cellular Componentsynaptic vesicle
Molecular Function1-phosphatidylinositol binding
Molecular Functionclathrin binding
Molecular Functionclathrin heavy chain binding
Molecular Functionphosphatidylinositol-4,5-bisphosphate binding
Molecular FunctionSNARE binding
Biological Processclathrin coat assembly
Biological Processclathrin-dependent endocytosis
Biological Processlocomotion
Biological Processnecroptotic process
Biological Processpost-embryonic development
Biological Processprotein localization to postsynaptic membrane
Biological Processreceptor-mediated endocytosis
Biological Processregulation of receptor localization to synapse
Biological Processsynaptic vesicle budding from presynaptic endocytic zone membrane
Biological Processsynaptic vesicle endocytosis
Biological Processubiquitin-dependent protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylinositol-binding clathrin assembly protein unc-11
  • Alternative names
    • AP180-like adaptor protein
    • Uncoordinated protein 11

Gene names

    • Name
      unc-11
    • ORF names
      C32E8.10

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q9XZI6
  • Secondary accessions
    • Q95Q72
    • Q95Q73
    • Q95Q74
    • Q95Q75
    • Q9UA04

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001870651-586Phosphatidylinositol-binding clathrin assembly protein unc-11

Proteomic databases

PTM databases

Expression

Tissue specificity

High levels in the nervous system and at lower levels in other tissues. In neurons, enriched at presynaptic terminals and is also present in cell bodies.

Gene expression databases

    • WBGene00006751Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues

Interaction

Subunit

Binds clathrin and phosphatidylinositol 4,5-bisphosphate.

Binary interactions

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain29-161ENTH
Region450-474Disordered

Sequence similarities

Belongs to the PICALM/SNAP91 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (9)
  • Sequence status
    Complete

This entry describes 9 isoforms produced by Alternative splicing.

Q9XZI6-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    A
  • Synonyms
    a
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    586
  • Mass (Da)
    64,064
  • Last updated
    1999-11-01 v1
  • Checksum
    6E337A81D302DD81
MQTIEKALHQPMPFTTGGQTISDRLTAAKHSLAGSQLGKTICKATTEEVMAPKKKHLDYLLHCTNEPNVSIPSMANLLIERTQNPNWTVVYKALITIHNIMCYGNERFSQYLASCNTTFNLTAFVDKVGGAGGYDMSTHVRRYAKYIGEKINTYRMCAFDFCKVKRGREDGLLRTMHTDKLLKTIPILQNQIDALLEFSVTTSELNNGVINCSFILLFRDLIRLFACYNDGIINVLEKYFDMNKKQCRDALDTYKSFLTRLDKVAEFLRVAESVGIDRGEIPDLTRAPASLLEALEAHLIHLEGGKAPPPTQQHVAPHQFTTGFAFSQQPQPALGDAERQRYIELEQERLRQFEDQKKSINSANPFANDVASAAPAPATSAAQPDLLDMFQSSAAPAPQTADVTNPFGNFAAPSAFPTNVPPPAAHSAPFGVQPAPQHSAAPFYANLHQAPPMQSQAPNGHQAAPFGYPNAHPDDLARMTAQMSLNQQGAPAGWNTTTSAVSNNPFGATSAPQPMYTAPMGMYQQPFGAQPMWNPAMAAYGQQYGYGQPVPPQQQHQIQLVHAAMAAKNAAQAQQAQAASADPFGL

Q9XZI6-2

  • Name
    B
  • Synonyms
    h
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9XZI6-3

  • Name
    C
  • Synonyms
    b
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9XZI6-7

  • Name
    c
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 459-459: N → NEPENPFITAPAAPQMHNAPPVPPPPASQGAPAPINPFADPSATAASSAQPFGDPDDFKFEQKNVKIKILIP

Q9XZI6-4

Q9XZI6-8

  • Name
    d
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9XZI6-5

  • Name
    E
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9XZI6-9

  • Name
    e
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 383-467: QPDLLDMFQSSAAPAPQTADVTNPFGNFAAPSAFPTNVPPPAAHSAPFGVQPAPQHSAAPFYANLHQAPPMQSQAPNGHQAAPFG → HQCIRLQWECINNHLVLSQCGILRWQHTVNNMDTDNLFHHNSNTKFNWFMQRWLQRTLHKLNRPRPPQPIHLDYSLVVYFSLSLS
    • 468-586: Missing

Q9XZI6-6

  • Name
    f
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0506791-388in isoform f
Alternative sequenceVSP_020098383-467in isoform e
Alternative sequenceVSP_050680383-512in isoform E
Alternative sequenceVSP_020099397-408in isoform d
Alternative sequenceVSP_050681397-449in isoform D
Alternative sequenceVSP_020100409-460in isoform d
Alternative sequenceVSP_050682419-458in isoform C and isoform B
Alternative sequenceVSP_020101459in isoform c
Alternative sequenceVSP_020102468-586in isoform e
Alternative sequenceVSP_050683489in isoform B and isoform D

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF144257
EMBL· GenBank· DDBJ
AAD37365.1
EMBL· GenBank· DDBJ
mRNA
AF144258
EMBL· GenBank· DDBJ
AAD37366.1
EMBL· GenBank· DDBJ
mRNA
AF144259
EMBL· GenBank· DDBJ
AAD37367.1
EMBL· GenBank· DDBJ
mRNA
AF144260
EMBL· GenBank· DDBJ
AAD37368.1
EMBL· GenBank· DDBJ
mRNA
AF144261
EMBL· GenBank· DDBJ
AAD37369.1
EMBL· GenBank· DDBJ
mRNA
AF144262
EMBL· GenBank· DDBJ
AAD37370.1
EMBL· GenBank· DDBJ
mRNA
FO080749
EMBL· GenBank· DDBJ
CCD66409.1
EMBL· GenBank· DDBJ
Genomic DNA
FO080749
EMBL· GenBank· DDBJ
CCD66410.1
EMBL· GenBank· DDBJ
Genomic DNA
FO080749
EMBL· GenBank· DDBJ
CCD66411.1
EMBL· GenBank· DDBJ
Genomic DNA
FO080749
EMBL· GenBank· DDBJ
CCD66412.1
EMBL· GenBank· DDBJ
Genomic DNA
FO080749
EMBL· GenBank· DDBJ
CCD66413.1
EMBL· GenBank· DDBJ
Genomic DNA
FO080749
EMBL· GenBank· DDBJ
CCD66414.1
EMBL· GenBank· DDBJ
Genomic DNA
FO080749
EMBL· GenBank· DDBJ
CCD66415.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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