Q9XZ06 · NU931_DROME

Function

function

Required for nuclear pore complex assembly, maintenance and function (PubMed:20547758, PubMed:22718353).
Required for nuclear import of phosphorylated Mad via importin msk (PubMed:20547758).
Has no role in classical nuclear localization signal (cNLS)-dependent nuclear import via importin-beta (PubMed:20547758).
Mediates the association between the nuclear pore complex and a subclass of silenced regions bound by Polycomb group (PcG) proteins, enables long-range interactions between Polycomb loci and contributes to repression of polycomb targets (PubMed:31784359).
Together with Nup62 and Nup154, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells (PubMed:26341556).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnuclear membrane
Cellular Componentnuclear periphery
Cellular Componentnuclear pore
Cellular Componentnuclear pore nuclear basket
Cellular Componentnucleoplasm
Molecular Functionchromatin binding
Molecular Functionchromatin DNA binding
Molecular Functionstructural constituent of nuclear pore
Biological Processchromosome attachment to the nuclear envelope
Biological Processnegative regulation of gene expression, epigenetic
Biological Processnuclear pore organization
Biological Processoocyte karyosome formation
Biological Processpoly(A)+ mRNA export from nucleus
Biological Processprotein import into nucleus
Biological Processprotein localization to nuclear inner membrane
Biological Processregulation of nucleus size

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nuclear pore complex protein Nup93-1
  • Alternative names
    • Nucleoporin 93kD-1
    • Nucleoporin Nup93-1

Gene names

    • Name
      Nup93-1
    • ORF names
      CG11092

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9XZ06

Proteomes

Organism-specific databases

Subcellular Location

Nucleus membrane
Nucleus, nucleoplasm
Note: When not in the nuclear pore complex, can localize to the nuclear lumen proximal to the inner nuclear membrane.

Keywords

Phenotypes & Variants

Disruption phenotype

RNAi-mediated knockdown in oocytes and nurse cells results in irregular distribution of chromatin to the nuclear periphery, leading to disrupted karyosome morphology (PubMed:26341556).
RNAi-mediated knockdown in the wing disk results in de-repression of genes silenced by the Polycomb group proteins complexes such Abd-B (PubMed:31784359).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004425281-823Nuclear pore complex protein Nup93-1

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Part of the nuclear pore complex (NPC) (By similarity).
Interacts with msk (via C-terminus); this association might be facilitated by Nup75 (PubMed:20547758).
Interacts with Mad (preferentially when phosphorylated) (PubMed:20547758).
Interacts with Nup154 (via N-terminus) (PubMed:22718353).
Interacts with the Polycomb group (PcG) proteins Pc and E(z) (PubMed:31784359).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9XZ06Nup154 Q9V4633EBI-179313, EBI-118619

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the nucleoporin interacting component (NIC) family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    823
  • Mass (Da)
    93,852
  • Last updated
    1999-11-01 v1
  • Checksum
    48FC37512C77B9D2
MDLMELLKQAQRLTNETNTDTEVPGVERTMSQVLQATKEFHSRVTQMGTNDLQAHILLGSKGVDLPKLTQKLESLSARQTFEPIDPVTETNVQAYLKNERENAILSVIDETNRSIFKSVERQKWRCIYSEWGEEKEALLNALVGPNQQDFPDVQFQIVPTAMADEPTPYSQLNGHEQMYAEQIAIHNQSIILGRRPNLLSTLAHVVQDSFNDESVAEMWNVLQFMTALPPVSSTIDPIKNRQTSPQFVEQARTYLERRYRTYMRKFIVANLAKARRGGIPSVYHMVRSYVGVTLQGQRALYGLHDVNNGQPLWPHVYYSLRSGDMDAAALYLKESGTCPDLLTLLTLRKNGDRDNLMVKLEGQLKLEYNSRLRACTDPYKKAVYVVLLACDPHFTHVELMRSIDDFLWMQLSILRRSDQSDSNTEQLTFSGLQSLILEKYGENYFNAREKAALYFQVLTLTGQFEAAIEFLARTEKNRTHAIHMAIALNEISMLGTPRSVEQSLLSSDPDDPKPMKRLNLVRLIVMYTKCFERTDTTQALHYYYLLRNFKSENGRGNVMLTCVCDLLVEKCDDEMLELIFGTEDKKNGLRYGGIYAEFQIHECDKYSLAEMVGDELSKRGDYELAIELYFIGGQLDKALRLVNSLLAQVVHQPTQNGSVRNRLGDIINRLDAALVVRKSDVEVQVVVTYTVLTKVMKFFDHYHEGALRSALEILTNNHLIPASSLEVDECVTNIKRMGPEVIKVLPDILLASMDIVYQEYVKLMDSNETASGFFDESKCVNKEPAVKHLRDRAKAFTNMAASVPYRMPSTTNQRLVQLEILMH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014298
EMBL· GenBank· DDBJ
AAF48327.1
EMBL· GenBank· DDBJ
Genomic DNA
AF132159
EMBL· GenBank· DDBJ
AAD34747.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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