Q9XZ06 · NU931_DROME
- ProteinNuclear pore complex protein Nup93-1
- GeneNup93-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids823 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required for nuclear pore complex assembly, maintenance and function (PubMed:20547758, PubMed:22718353).
Required for nuclear import of phosphorylated Mad via importin msk (PubMed:20547758).
Has no role in classical nuclear localization signal (cNLS)-dependent nuclear import via importin-beta (PubMed:20547758).
Mediates the association between the nuclear pore complex and a subclass of silenced regions bound by Polycomb group (PcG) proteins, enables long-range interactions between Polycomb loci and contributes to repression of polycomb targets (PubMed:31784359).
Together with Nup62 and Nup154, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells (PubMed:26341556).
Required for nuclear import of phosphorylated Mad via importin msk (PubMed:20547758).
Has no role in classical nuclear localization signal (cNLS)-dependent nuclear import via importin-beta (PubMed:20547758).
Mediates the association between the nuclear pore complex and a subclass of silenced regions bound by Polycomb group (PcG) proteins, enables long-range interactions between Polycomb loci and contributes to repression of polycomb targets (PubMed:31784359).
Together with Nup62 and Nup154, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells (PubMed:26341556).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nuclear membrane | |
Cellular Component | nuclear periphery | |
Cellular Component | nuclear pore | |
Cellular Component | nuclear pore nuclear basket | |
Cellular Component | nucleoplasm | |
Molecular Function | chromatin binding | |
Molecular Function | chromatin DNA binding | |
Molecular Function | structural constituent of nuclear pore | |
Biological Process | chromosome attachment to the nuclear envelope | |
Biological Process | negative regulation of gene expression, epigenetic | |
Biological Process | nuclear pore organization | |
Biological Process | oocyte karyosome formation | |
Biological Process | poly(A)+ mRNA export from nucleus | |
Biological Process | protein import into nucleus | |
Biological Process | protein localization to nuclear inner membrane | |
Biological Process | regulation of nucleus size |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNuclear pore complex protein Nup93-1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9XZ06
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: When not in the nuclear pore complex, can localize to the nuclear lumen proximal to the inner nuclear membrane.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
RNAi-mediated knockdown in oocytes and nurse cells results in irregular distribution of chromatin to the nuclear periphery, leading to disrupted karyosome morphology (PubMed:26341556).
RNAi-mediated knockdown in the wing disk results in de-repression of genes silenced by the Polycomb group proteins complexes such Abd-B (PubMed:31784359).
RNAi-mediated knockdown in the wing disk results in de-repression of genes silenced by the Polycomb group proteins complexes such Abd-B (PubMed:31784359).
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000442528 | 1-823 | Nuclear pore complex protein Nup93-1 | |||
Sequence: MDLMELLKQAQRLTNETNTDTEVPGVERTMSQVLQATKEFHSRVTQMGTNDLQAHILLGSKGVDLPKLTQKLESLSARQTFEPIDPVTETNVQAYLKNERENAILSVIDETNRSIFKSVERQKWRCIYSEWGEEKEALLNALVGPNQQDFPDVQFQIVPTAMADEPTPYSQLNGHEQMYAEQIAIHNQSIILGRRPNLLSTLAHVVQDSFNDESVAEMWNVLQFMTALPPVSSTIDPIKNRQTSPQFVEQARTYLERRYRTYMRKFIVANLAKARRGGIPSVYHMVRSYVGVTLQGQRALYGLHDVNNGQPLWPHVYYSLRSGDMDAAALYLKESGTCPDLLTLLTLRKNGDRDNLMVKLEGQLKLEYNSRLRACTDPYKKAVYVVLLACDPHFTHVELMRSIDDFLWMQLSILRRSDQSDSNTEQLTFSGLQSLILEKYGENYFNAREKAALYFQVLTLTGQFEAAIEFLARTEKNRTHAIHMAIALNEISMLGTPRSVEQSLLSSDPDDPKPMKRLNLVRLIVMYTKCFERTDTTQALHYYYLLRNFKSENGRGNVMLTCVCDLLVEKCDDEMLELIFGTEDKKNGLRYGGIYAEFQIHECDKYSLAEMVGDELSKRGDYELAIELYFIGGQLDKALRLVNSLLAQVVHQPTQNGSVRNRLGDIINRLDAALVVRKSDVEVQVVVTYTVLTKVMKFFDHYHEGALRSALEILTNNHLIPASSLEVDECVTNIKRMGPEVIKVLPDILLASMDIVYQEYVKLMDSNETASGFFDESKCVNKEPAVKHLRDRAKAFTNMAASVPYRMPSTTNQRLVQLEILMH |
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Part of the nuclear pore complex (NPC) (By similarity).
Interacts with msk (via C-terminus); this association might be facilitated by Nup75 (PubMed:20547758).
Interacts with Mad (preferentially when phosphorylated) (PubMed:20547758).
Interacts with Nup154 (via N-terminus) (PubMed:22718353).
Interacts with the Polycomb group (PcG) proteins Pc and E(z) (PubMed:31784359).
Interacts with msk (via C-terminus); this association might be facilitated by Nup75 (PubMed:20547758).
Interacts with Mad (preferentially when phosphorylated) (PubMed:20547758).
Interacts with Nup154 (via N-terminus) (PubMed:22718353).
Interacts with the Polycomb group (PcG) proteins Pc and E(z) (PubMed:31784359).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9XZ06 | Nup154 Q9V463 | 3 | EBI-179313, EBI-118619 |
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length823
- Mass (Da)93,852
- Last updated1999-11-01 v1
- Checksum48FC37512C77B9D2
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014298 EMBL· GenBank· DDBJ | AAF48327.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF132159 EMBL· GenBank· DDBJ | AAD34747.1 EMBL· GenBank· DDBJ | mRNA |