Q9XXQ9 · HMT12_CAEEL

  • Protein
    Proton myo-inositol cotransporter hmit-1.2
  • Gene
    hmit-1.2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

H+-myo-inositol cotransporter (By similarity).
Probably by promoting the transport of myo-inositol regulates intracellular osmosis in response to hyperosmotic stress (PubMed:21679696).

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbasal plasma membrane
Cellular Componentperikaryon
Molecular Functionmyo-inositol:proton symporter activity
Biological Processmyo-inositol transport
Biological Processtransmembrane transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Proton myo-inositol cotransporter hmit-1.2
  • Short names
    H(+)-myo-inositol cotransporter hmit-1.2
  • Alternative names
    • H(+)-myo-inositol symporter hmit-1.2

Gene names

    • Name
      hmit-1.2
    • ORF names
      Y51A2D.5

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q9XXQ9

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Perikaryon
Note: Localizes to the lumenal side of intestinal cells (PubMed:21679696).
Localizes to the endfoot region of glial cells where the cilia of sensory neurons are embedded (PubMed:21679696).
In the excretory canal cell, localizes to the basal membrane of the distal canal and at the lumenal membrane of the proximal canal (PubMed:21679696).

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-21Cytoplasmic
Transmembrane22-42Helical; Name=1
Topological domain43-69Extracellular
Transmembrane70-90Helical; Name=2
Topological domain91-96Cytoplasmic
Transmembrane97-117Helical; Name=3
Topological domain118-119Extracellular
Transmembrane120-140Helical; Name=4
Topological domain141-157Cytoplasmic
Transmembrane158-178Helical; Name=5
Topological domain179-189Extracellular
Transmembrane190-210Helical; Name=6
Topological domain211-279Cytoplasmic
Transmembrane280-300Helical; Name=7
Topological domain301-317Extracellular
Transmembrane318-338Helical; Name=8
Topological domain339-347Cytoplasmic
Transmembrane348-368Helical; Name=9
Topological domain369-472Extracellular
Transmembrane473-493Helical; Name=10
Topological domain494-515Cytoplasmic
Transmembrane516-536Helical; Name=11
Topological domain537-539Extracellular
Transmembrane540-560Helical; Name=12
Topological domain561-613Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00004502121-613Proton myo-inositol cotransporter hmit-1.2
Glycosylation372N-linked (GlcNAc...) asparagine
Glycosylation451N-linked (GlcNAc...) asparagine
Glycosylation456N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the excretory canal cell and in pairs of amphid and sheath glia.

Induction

Induced by hyperosmotic stress.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region594-613Disordered
Compositional bias599-613Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    613
  • Mass (Da)
    67,886
  • Last updated
    1999-11-01 v1
  • Checksum
    EAD220793DD2B2F1
MVAVEFKVSESGRPRPEKNPKLGFFVYLLGSAAIIGGFLFGYDTSVVSAAMLYVPEAPGLKPMGTVWKEVIVSITPGMAAVGAWFSGAGSDRYGRKPIIIGSTLIFVCGAVICAVAWTKIVMLIGRIFLGVGIGFASMVVPVYLGEASPTHVRGTLVSAFAMMISFGQVVANIMGGVFSYWEPYTIGWRLMFAFAGIPALIQFVCFIFLPETPRWLYENGHTEQAEQVLEKIYGGNTEWIEYELAEIKTYAEERQKQMEEEKKSGPVIWRILKTPHVLKACFIGSMLQAFQQLAGINTILYYTADIIRSAGIENYHTIIWISVILSICNLIGPFAPMFFIEKLGRRKLFLFSCAGVVVSLVLIGVSFLLVGNDSAPNFDRSAYLLAGNYQSNGEAESCLMLSNCDSCVTSEHCGFCEDSETRTGFCLPVDHNDVTLYSSTGLCTNGLDKSNSSFPNATSYVWQKHHCTTSYTILPIVMMGVYLLTFSCGFTSLPWVLNSEFYPMWARSTCVSISTLSNWVFNLIIALTYLSLTHAITKYGAFWLYAIFTIIAFIFIYFLVPETTGYSIDEVEMLFMNKRQRNIAMQARQAKLDAASDKDKNSSTSLSTETITM

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias599-613Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284605
EMBL· GenBank· DDBJ
CAA16405.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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