Q9XWI6 · EIF3B_CAEEL

  • Protein
    Eukaryotic translation initiation factor 3 subunit B
  • Gene
    eif-3.B
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenteukaryotic 43S preinitiation complex
Cellular Componenteukaryotic 48S preinitiation complex
Cellular Componenteukaryotic translation initiation factor 3 complex
Molecular FunctionRNA binding
Molecular Functiontranslation initiation factor activity
Molecular Functiontranslation initiation factor binding
Biological Processformation of cytoplasmic translation initiation complex
Biological Processregulation of translational initiation
Biological Processtranslational initiation

Keywords

Enzyme and pathway databases

    • R-CEL-156827L13a-mediated translational silencing of Ceruloplasmin expression
    • R-CEL-72649Translation initiation complex formation
    • R-CEL-72689Formation of a pool of free 40S subunits
    • R-CEL-72695Formation of the ternary complex, and subsequently, the 43S complex
    • R-CEL-72702Ribosomal scanning and start codon recognition

Names & Taxonomy

Protein names

  • Recommended name
    Eukaryotic translation initiation factor 3 subunit B
  • Short names
    eIF3b
  • Alternative names
    • Eukaryotic translation initiation factor 3 subunit 9

Gene names

    • Name
      eif-3.B
    • ORF names
      Y54E2A.11

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q9XWI6
  • Secondary accessions
    • Q7K785

Proteomes

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

Extended lifespan in adults.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003637891-725Eukaryotic translation initiation factor 3 subunit B

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, repeat.

TypeIDPosition(s)Description
Domain46-130RRM
Repeat202-240WD 1
Repeat242-280WD 2
Repeat354-395WD 3
Repeat462-504WD 4
Repeat510-552WD 5
Repeat554-594WD 6

Sequence similarities

Belongs to the eIF-3 subunit B family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9XWI6-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    725
  • Mass (Da)
    83,065
  • Last updated
    2013-07-24 v2
  • Checksum
    C73A8E862A32F887
MVEIDFNKENEEDFSDPPGFVDDVTDDVLVPDVLHKKPTIDEFEDNCVFIAGIPVVGADRLGKLQSVLKKVLERLDPAVKLYIPPSPEGGCLGVLLTEWADQRSAQFAVKSLNGYAFDKNHTFTARSFKDMKQLEAPSDHWTTPEKQAYNDVGDLWWWLQNERCRDQFAISHDKLGVPTVGVFTNMKGNDPELAGDADKAERANWTETVFTWSPHGSYLSTIHKQGIILWGGKDYARAHRFAHTNVQYIDFSPCETYLVTYAAPEESNSWGDCEKDSLRIWDVRTGELKKAFSTFELTGRTQLPTWPFFRWSFDEKYFACLKAPEKDKLEREQKINGISIFESEKFELYEGRPVNIENIKQFEWSPTSTVLAYYSECTDAVPAEFGLLQVPSMQRLRSARVHNVADAQMFWQKSGKRLAFYTMRFKKKEYRETGEVKYVGGCQYHVDIFEIDKKDVSLMNLPLSEPFIHFDWDPEGDKFCVLVGNTAKATPQVYKIEANSHAPKLVSKLDAGVHFNEVQFAPKGGWLAVLAKVSAGGNVYFIDTSLSEAKRTNVIEHPLFNKGYWDPTGRYFVTCSTLGGRAGADLGYRIFTFQGRELCRKNLDRLAQFKWRPRPPVKLSEQKQREIKKNLKKTAAKFIKQDDDEKCRASQEVVEKRRKIMAAFDIIRSRNREQLDATRDERISLRNGVDTEAQLDEDEFVDEEITIALSTSKTQAPLTEEEMRD

Q9XWI6-2

  • Name
    b
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 149-193: YNDVGDLWWWLQNERCRDQFAISHDKLGVPTVGVFTNMKGNDPEL → KTTLVPTVSLIPTFNTLISRRVRPTLLPTPLRKSRTAGETVRRIV
    • 194-725: Missing

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_047618149-193in isoform b
Alternative sequenceVSP_047619194-725in isoform b

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284602
EMBL· GenBank· DDBJ
CAA21681.2
EMBL· GenBank· DDBJ
Genomic DNA
BX284602
EMBL· GenBank· DDBJ
CAE46682.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp