While no change in mRNA expression of the major Mn importer proteins (smf-1-3) was found in pdr-1 mutants significant downregulation in mRNA levels of the putative Mn exporter ferroportin (fpn-1.1) was observed.
These data show that mutation in the Caenorhabditis elegans orthologue of Parkin (pdr-1) modulates the level of a large heteroplasmic mtDNA truncation.
In contrast to pdr-1 loss-of-function mutants an in-frame parkin homolog pdr-1 deletion variant with altered solubility and intracellular localization properties is hypersensitive toward different proteotoxic stress conditions.
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