Q9XUB9 · NRA1_CAEEL
- ProteinNicotinic receptor-associated protein 1
- Genenra-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids634 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Exhibits calcium-dependent phospholipid binding properties (By similarity).
May function in membrane trafficking. Regulates synaptic levels of nicotinic acetylcholine receptor subunit lev-1 and unc-38 in the nerve cord (PubMed:15990870).
Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole (PubMed:15990870).
Affects directional sperm motility (PubMed:16998478).
May function in membrane trafficking. Regulates synaptic levels of nicotinic acetylcholine receptor subunit lev-1 and unc-38 in the nerve cord (PubMed:15990870).
Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole (PubMed:15990870).
Affects directional sperm motility (PubMed:16998478).
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 29 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Binding site | 30 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 30 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 36 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 105 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 105 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 107 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 107 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 119 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 189 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 189 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 195 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 251 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 251 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 253 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 253 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 271 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | calcium-dependent phospholipid binding | |
Molecular Function | metal ion binding | |
Biological Process | cellular response to calcium ion | |
Biological Process | receptor localization to synapse |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNicotinic receptor-associated protein 1
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ9XUB9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Phenotypes & Variants
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000144851 | 1-634 | Nicotinic receptor-associated protein 1 | |||
Sequence: MNQPIGIADSSRPKTNVRLTISANNLMDLDVFSKSDPICLIYEKTSGRKATTTEEITVPTWKDKQWTERGRTEVVMNNLNPQFTKTFLLPYFFEETQLLRFEIYDADSPTVGQDLSSHDFLGRFECVLAQIVSYSTLKAHLGKTGQIGAQWRNKDKNTKTGSITIYAEEDEKAEKIQFDVCGEGLDKKDFFGKSDPYLNFKRKFDDGSTHLIHRTEVKPKTLDPRWATVQINTQTLCAKDGDRPIIIECYDHDKWKKGEEPRGDAKFSRDDLIGTAQTTLNELLRGSSDAVEILLTNEKKKAKKGDKYKCSGTLKIWNSRIVIEPTFLDFISGGTQLDFAVAVDFTASNGPPKSSSSLHFMSADRPNQYELALRSVLSICQHYNSSKTFEAFGFGAKLPNQSSVSAIFPLDLQRGTSEVVGITGVMTAYRHALSNVQLYGPTNFAPIIENVARKAQNMIHDSARYQILLIITDGIISDMHATIRSIISASGLPLSIIIIGVGNEDFEKMHELDSDDALLQQDSRIAQRDIVQFVTMREFLNNGQGLYLDPDVIQENLAREVLYEVPAQLTGYMKQRGFQPRPVDDPWRRDSPPPEFDPILDGTGRRAPMLQAPPAGFQYPVYADTSIASAPPMY |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in head and tail neurons, ventral cord moto-neurons, body wall muscles and hypodermal cells of the vulva.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-141 | C2 1 | ||||
Sequence: MNQPIGIADSSRPKTNVRLTISANNLMDLDVFSKSDPICLIYEKTSGRKATTTEEITVPTWKDKQWTERGRTEVVMNNLNPQFTKTFLLPYFFEETQLLRFEIYDADSPTVGQDLSSHDFLGRFECVLAQIVSYSTLKAHL | ||||||
Domain | 159-295 | C2 2 | ||||
Sequence: KTGSITIYAEEDEKAEKIQFDVCGEGLDKKDFFGKSDPYLNFKRKFDDGSTHLIHRTEVKPKTLDPRWATVQINTQTLCAKDGDRPIIIECYDHDKWKKGEEPRGDAKFSRDDLIGTAQTTLNELLRGSSDAVEILL | ||||||
Domain | 338-557 | VWFA | ||||
Sequence: DFAVAVDFTASNGPPKSSSSLHFMSADRPNQYELALRSVLSICQHYNSSKTFEAFGFGAKLPNQSSVSAIFPLDLQRGTSEVVGITGVMTAYRHALSNVQLYGPTNFAPIIENVARKAQNMIHDSARYQILLIITDGIISDMHATIRSIISASGLPLSIIIIGVGNEDFEKMHELDSDDALLQQDSRIAQRDIVQFVTMREFLNNGQGLYLDPDVIQENL | ||||||
Region | 576-603 | Disordered | ||||
Sequence: RGFQPRPVDDPWRRDSPPPEFDPILDGT | ||||||
Compositional bias | 581-595 | Basic and acidic residues | ||||
Sequence: RPVDDPWRRDSPPPE |
Domain
C2 domains are necessary for calcium-dependent cell membrane association. C2 domains are necessary for neuronal progenitor cell differentiation in a calcium-independent manner.
Sequence similarities
Belongs to the copine family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9XUB9-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Namea
- Length634
- Mass (Da)71,101
- Last updated1999-11-01 v1
- Checksum9CF95130F9A2DCCE
Q9XUB9-2
- Nameb
- Differences from canonical
- 258-269: Missing
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_039297 | 258-269 | in isoform b | |||
Sequence: Missing | ||||||
Compositional bias | 581-595 | Basic and acidic residues | ||||
Sequence: RPVDDPWRRDSPPPE |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z82285 EMBL· GenBank· DDBJ | CAB05302.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z82285 EMBL· GenBank· DDBJ | CAD56248.1 EMBL· GenBank· DDBJ | Genomic DNA |