Q9XTQ6 · TBH1_CAEEL

  • Protein
    Tyramine beta-hydroxylase
  • Gene
    tbh-1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Required for the conversion of tyramine to octopamine, a precursor of octapamine but probably itself a neurotransmitter (PubMed:15848803).
Involved in the regulation of egg laying, which is inhibited by tyramine (PubMed:15848803).
Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity (PubMed:25723162).

Catalytic activity

Cofactor

Cu2+ (UniProtKB | Rhea| CHEBI:29036 )

Note: Binds 2 copper ions per subunit.

Features

Showing features for active site, binding site.

165750100150200250300350400450500550600650
TypeIDPosition(s)Description
Active site278
Binding site312Cu2+ A (UniProtKB | ChEBI)
Binding site313Cu2+ A (UniProtKB | ChEBI)
Binding site380Cu2+ A (UniProtKB | ChEBI)
Active site458
Binding site458Cu2+ B (UniProtKB | ChEBI)
Binding site460Cu2+ B (UniProtKB | ChEBI)
Binding site533Cu2+ B (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular space
Cellular Componentsecretory granule membrane
Cellular Componentsynapse
Molecular Functioncopper ion binding
Molecular Functiondopamine beta-monooxygenase activity
Molecular Functiontyramine-beta hydroxylase activity
Biological Processdopamine catabolic process
Biological Processnorepinephrine biosynthetic process
Biological Processoctopamine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyramine beta-hydroxylase
  • EC number
  • Alternative names
    • Tyramine beta-monooxygenase (TbetaM)

Gene names

    • Name
      tbh-1
    • ORF names
      H13N06.6

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q9XTQ6
  • Secondary accessions
    • C6KRQ4

Proteomes

Organism-specific databases

Subcellular Location

Isoform b

Membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane77-97Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Worms are viable and healthy, but have slightly reduced locomotion rates, and defects in the inhibition of pharyngeal pumping and egg laying in the absence of food.

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00003052151-657Tyramine beta-hydroxylase
Glycosylation104N-linked (GlcNAc...) asparagine
Glycosylation143N-linked (GlcNAc...) asparagine
Disulfide bond280↔330
Disulfide bond319↔342
Disulfide bond437↔549
Disulfide bond441↔606
Disulfide bond512↔534
Glycosylation555N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Present in synaptic regions of RIC interneurons. Present in gonadal sheath cells of hermaphrodites (at protein level).

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain103-214DOMON

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9XTQ6-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    657
  • Mass (Da)
    74,963
  • Last updated
    2015-06-24 v3
  • Checksum
    424CFDBFF2BFCE90
MEPTASQGIQYLRGGVEWILKLLNLHILNVKHENKPLLFRLIDLKVYIPSSVSTVRWSSGASSYVILGEYRKMRSAVALLFLLVAYCGGVVHAGEIVAELYHTNVTVKWHTDYERQLVDFSIWFGASTPDVLFLGFSDFGDTNNSDVLMYYNSKKEIKDAYTNRDFKITSDLQQDFQLLRKRKDHIVVRRKLTTCDSRDYAFLPGTTQFYIAASWGSTNLVDIRDKRWVVDKKFGKVIEGPTDQPNIEEEPAALEKDVKVVIVNSNSPDPIPNVETTYKCIIRKMPFDTVNNMYHVVRMEPYVTPGNEHLVHHMEIFMCRDEVEEWSGSCNDPKKPPKSKSCSHVIAAWAMGEGPIHYPKEAGLPIGGKGKNAYVMVEIHYNNPELHKGVIDSSGFQFFVTGQLRKYDAGIMELGLIYSDANSVPPNQKAWAMNGYCPSQCTKNLPEEGINIFASQLHAHLTGRKLFTSQYRSGVRIGDVNRDEHYSPHWQHLQQLRPVVKVMPGDTLVTTCVYDTRKRSKVTFGGYRIVDEMCVNYIYYYPASDVEVCKSAISNSTLRAYFSERHGMDGKRMQISDMYSNVKDWGNGVDEEFYNVLNVGNMNMNCLKSNGEPFEFESKDSRQSWENMARPTFVSGSFITTRDRFQCPAINDMINFE

Q9XTQ6-2

  • Name
    a
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0K3ATC0A0A0K3ATC0_CAEELtbh-1606

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0577381-72in isoform a

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z99942
EMBL· GenBank· DDBJ
CAB17071.2
EMBL· GenBank· DDBJ
Genomic DNA
BX284606
EMBL· GenBank· DDBJ
CAZ65507.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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