Q9XI87 · VIK_ARATH

Function

function

Serine/threonine protein kinase which may function as an adapter protein for BRL2 (PubMed:19000166).
Required during vascular development for the establishment of vein pattern in foliar organs (PubMed:19000166).
Mediates MSSP1/TMT1 phosphorylation and activation to enhance its carrier activity and consequently vacuolar sugar accumulation, particularly in response to cold (PubMed:21838775).

Catalytic activity

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site168-176ATP (UniProtKB | ChEBI)
Binding site189ATP (UniProtKB | ChEBI)
Active site285Proton acceptor

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular Componentplant-type vacuole
Molecular FunctionATP binding
Molecular FunctionMAP kinase kinase kinase activity
Molecular Functionprotein serine/threonine/tyrosine kinase activity
Biological Processauxin-activated signaling pathway
Biological Processbrassinosteroid mediated signaling pathway
Biological Processcellular response to glucose stimulus
Biological Processleaf vascular tissue pattern formation
Biological Processpositive regulation of glucose transmembrane transport
Biological Processresponse to auxin
Biological Processresponse to salt

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein kinase VIK
  • EC number
  • Alternative names
    • VH1-interacting kinase

Gene names

    • Name
      VIK
    • ORF names
      F16A14.22
      , F7A19.9
    • Ordered locus names
      At1g14000

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9XI87
  • Secondary accessions
    • Q56ZU2
    • Q8S9J9
    • Q9LMF8

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Reduced sensitivity to auxin (e.g. 2,4-D and NPA) and brassinosteroids (BRs) associated with altered vein pattern in foliar organs (PubMed:19000166).
Decreased vacuolar sugar import associated with reduced fresh weight when grown on high glucose containing medium or in response to cold stress (PubMed:21838775).
Altered intracellular sugar compartmentation due to altered regulation of MSSP1/TMT1 (PubMed:21838775).

Variants

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The viewer provides 10 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004568101-438Serine/threonine-protein kinase VIK

Post-translational modification

Phosphorylated.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Restricted to mature vascular cells (PubMed:19000166).
Mostly expressed in mature leaves and seeds, and, to a lower level, in seedlings, young leaves, flowers and siliques (PubMed:21838775).

Induction

Induced by auxin (e.g. IAA) (PubMed:19000166).
Accumulates in response to salt (NaCl) (PubMed:21838775).

Gene expression databases

Interaction

Subunit

Interacts with BRL2 (PubMed:19000166).
Binds to MSSP1/TMT1 at the tonoplast (PubMed:21838775).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9XI87BRL2 Q9ZPS92EBI-2292778, EBI-2292728

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, repeat, domain.

TypeIDPosition(s)Description
Region1-31Disordered
Repeat36-65ANK 1
Repeat70-99ANK 2
Repeat103-133ANK 3
Domain162-427Protein kinase

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    438
  • Mass (Da)
    49,335
  • Last updated
    1999-11-01 v1
  • Checksum
    C61F80724E24BBD2
MSSDSPAAGDGGEQAAAGTSVPSPSYDKQKEKARVSRTSLILWHAHQNDAAAVRKLLEEDPTLVHARDYDKRTPLHVASLHGWIDVVKCLLEFGADVNAQDRWKNTPLADAEGARKQKMIELLKSHGGLSYGQNGSHFEPKPVPPPIPKKCDWEIEPAELDFSNAAMIGKGSFGEIVKAYWRGTPVAVKRILPSLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLGAVTERKPLMLITEYLRGGDLHQYLKEKGGLTPTTAVNFALDIARGMTYLHNEPNVIIHRDLKPRNVLLVNSSADHLKVGDFGLSKLIKVQNSHDVYKMTGETGSYRYMAPEVFKHRRYDKKVDVFSFAMILYEMLEGEPPFANHEPYEAAKHVSDGHRPTFRSKGCTPDLRELIVKCWDADMNQRPSFLDILKRLEKIKETLPSDHHWGLFTS

Sequence caution

The sequence AAF79405.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict17in Ref. 3; AAL77660

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC007576
EMBL· GenBank· DDBJ
AAD39286.1
EMBL· GenBank· DDBJ
Genomic DNA
AC068197
EMBL· GenBank· DDBJ
AAF79405.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002684
EMBL· GenBank· DDBJ
AEE29097.1
EMBL· GenBank· DDBJ
Genomic DNA
AY075653
EMBL· GenBank· DDBJ
AAL77660.1
EMBL· GenBank· DDBJ
mRNA
BT026491
EMBL· GenBank· DDBJ
ABH04598.1
EMBL· GenBank· DDBJ
mRNA
AK220869
EMBL· GenBank· DDBJ
BAD94246.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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