Q9XI31 · GLYI4_ARATH

Function

function

Involved in the detoxification and scavenging of methylglyoxal (MG), a cytotoxic aldehyde produced in response to primary metabolism alteration observed during biotic and abiotic stresses (PubMed:31652571).
Modulates cross-talk between salicylic acid (SA) and jasmonic acid (JA) signaling pathways during defense responses to pathogens such as Botrytis cinerea (PubMed:29852537).

Features

Showing features for active site.

117420406080100120140160
TypeIDPosition(s)Description
Active site131Proton donor/acceptor

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular Functionlyase activity
Biological Processcellular detoxification of methylglyoxal
Biological Processdefense response
Biological Processregulation of abscisic acid-activated signaling pathway
Biological Processregulation of jasmonic acid mediated signaling pathway
Biological Processregulation of salicylic acid mediated signaling pathway
Biological Processresponse to cold
Biological Processresponse to heat
Biological Processresponse to jasmonic acid
Biological Processresponse to methylglyoxal
Biological Processresponse to nickel cation
Biological Processresponse to osmotic stress
Biological Processresponse to oxidative stress
Biological Processresponse to salt
Biological Processresponse to UV-B
Biological Processresponse to water deprivation
Biological Processresponse to wounding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Glyoxylase I 4
  • Short names
    AtGLXI-like;4
    ; AtGLYI4

Gene names

    • Name
      GLYI4
    • ORF names
      F9L1.33
    • Ordered locus names
      At1g15380

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9XI31

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Cell membrane
Cytoplasm
Note: Localized at the plasma membrane during methylglyoxal (MG) accumulation, but translocates to the cytoplasm upon jasmonate (MeJA) stimulus.

Keywords

Phenotypes & Variants

Disruption phenotype

General stress phenotype, characterized by compromised methylglyoxal (MG) scavenging, accumulation of reactive oxygen species (ROS), stomatal closure, and reduced fitness associated with reduced leaf area and dry weight, as well as prolonged flowering time (PubMed:31652571).
Increased susceptibility to the pathogenic fungus Plectospherella cucumerina which triggers mainly the jasmonate (JA)-mediated defense signaling pathway (PubMed:31652571).
Abnormal cross-talk between salicylic acid (SA) and jasmonic acid (JA) signaling pathways (PubMed:29852537).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 6 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004539571-174Glyoxylase I 4

Proteomic databases

Expression

Tissue specificity

Mostly expressed in roots, and, to a lower extent, in leaves, flowers, seeds and siliques.

Induction

Accumulates in response to abiotic stresses such as cold, heat, drought, oxidative stress, genotoxic compounds, wounding, osmotic stress and UV-B (PubMed:21213008).
Slightly induced by salt (NaCl) and nickel ions Ni2+ (PubMed:21213008, PubMed:30483284).
Strongly induced by methylglyoxal (MG) (PubMed:31652571).

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain13-135VOC

Sequence similarities

Belongs to the glyoxalase I family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    174
  • Mass (Da)
    19,594
  • Last updated
    1999-11-01 v1
  • Checksum
    078B0EEBE1801054
MKEDAGNPLHLTSLNHVSVLCRSVDESMNFYQKVLGFIPIRRPESLNFEGAWLFGHGIGIHLLCAPEPEKLPKKTAINPKDNHISFQCESMGVVEKKLEEMGIDYVRALVEEGGIQVDQLFFHDPDGFMIEICNCDSLPVVPLVGEMARSCSRVKLHQMVQPQPQTQIHQVVYP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC007591
EMBL· GenBank· DDBJ
AAD39666.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE29312.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE29313.1
EMBL· GenBank· DDBJ
Genomic DNA
AY072377
EMBL· GenBank· DDBJ
AAL62369.1
EMBL· GenBank· DDBJ
mRNA
AY114619
EMBL· GenBank· DDBJ
AAM47938.1
EMBL· GenBank· DDBJ
mRNA
AK317354
EMBL· GenBank· DDBJ
BAH20026.1
EMBL· GenBank· DDBJ
mRNA
AY088300
EMBL· GenBank· DDBJ
AAM65839.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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