Q9XHZ8 · Y1178_ARATH
- ProteinBTB/POZ domain-containing protein At1g21780
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids326 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Pathway
Protein modification; protein ubiquitination.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Biological Process | protein ubiquitination |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBTB/POZ domain-containing protein At1g21780
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9XHZ8
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 204 | Abolishes the interaction with CUL3A. | ||||
Sequence: I → R | ||||||
Mutagenesis | 242 | Abolishes the interaction with CUL3A. | ||||
Sequence: Y → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 9 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000406090 | 1-326 | BTB/POZ domain-containing protein At1g21780 | |||
Sequence: MGDTKVETISRLAQWRIENFGPCSFKKSDPFKVGIWNWHLSIERNRYLSVRLFPELSRVSKEQPPVAKFVLRVSNVGPNRRFYISPVYEKLLRTTDDCVWHVDSSFHGRFTIDVEFLDLKICPVNGGEASPVWPTDATMQSISTQTTLKCLSRMLEESILTDVIIHTADGTLSAHKAILSASSTVFKSMFHHDLMEKESSTIHIDDMSRESCMALLSYLYGNITQEEFWKHRLALLGAANKYDITDLKAACEESLMEDINSSNVLERLQEAWLYQLEKLKKGCLMYLFDFGKIYDVREEISSFFRQADRELMLEMFQEVLSVWKPV |
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Homodimer. Interacts with CUL3A and CUL3B.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9XHZ8 | CUL3A Q9ZVH4 | 4 | EBI-541047, EBI-531362 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 161-228 | BTB | ||||
Sequence: TDVIIHTADGTLSAHKAILSASSTVFKSMFHHDLMEKESSTIHIDDMSRESCMALLSYLYGNITQEEF |
Domain
The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length326
- Mass (Da)37,678
- Last updated1999-11-01 v1
- Checksum34E3DB7AB972B25E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC007727 EMBL· GenBank· DDBJ | AAD41432.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | AEE30155.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | AEE30156.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT024719 EMBL· GenBank· DDBJ | ABD59057.1 EMBL· GenBank· DDBJ | mRNA | ||
AK228073 EMBL· GenBank· DDBJ | BAF00033.1 EMBL· GenBank· DDBJ | mRNA | ||
AY087548 EMBL· GenBank· DDBJ | AAM65090.1 EMBL· GenBank· DDBJ | mRNA |