Q9XHZ8 · Y1178_ARATH

Function

function

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Biological Processprotein ubiquitination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    BTB/POZ domain-containing protein At1g21780

Gene names

    • ORF names
      F8K7.22
    • Ordered locus names
      At1g21780

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9XHZ8
  • Secondary accessions
    • Q0WS66

Proteomes

Organism-specific databases

Genome annotation databases

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis204Abolishes the interaction with CUL3A.
Mutagenesis242Abolishes the interaction with CUL3A.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 9 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004060901-326BTB/POZ domain-containing protein At1g21780

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer. Interacts with CUL3A and CUL3B.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9XHZ8CUL3A Q9ZVH44EBI-541047, EBI-531362

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain161-228BTB

Domain

The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    326
  • Mass (Da)
    37,678
  • Last updated
    1999-11-01 v1
  • Checksum
    34E3DB7AB972B25E
MGDTKVETISRLAQWRIENFGPCSFKKSDPFKVGIWNWHLSIERNRYLSVRLFPELSRVSKEQPPVAKFVLRVSNVGPNRRFYISPVYEKLLRTTDDCVWHVDSSFHGRFTIDVEFLDLKICPVNGGEASPVWPTDATMQSISTQTTLKCLSRMLEESILTDVIIHTADGTLSAHKAILSASSTVFKSMFHHDLMEKESSTIHIDDMSRESCMALLSYLYGNITQEEFWKHRLALLGAANKYDITDLKAACEESLMEDINSSNVLERLQEAWLYQLEKLKKGCLMYLFDFGKIYDVREEISSFFRQADRELMLEMFQEVLSVWKPV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC007727
EMBL· GenBank· DDBJ
AAD41432.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE30155.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE30156.1
EMBL· GenBank· DDBJ
Genomic DNA
BT024719
EMBL· GenBank· DDBJ
ABD59057.1
EMBL· GenBank· DDBJ
mRNA
AK228073
EMBL· GenBank· DDBJ
BAF00033.1
EMBL· GenBank· DDBJ
mRNA
AY087548
EMBL· GenBank· DDBJ
AAM65090.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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