Q9XEX2 · PRX2B_ARATH

Function

function

Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin or glutaredoxin system. May be involved in intracellular redox signaling.
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule. C(P) is reactivated by glutaredoxin (Grx).

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site51Cysteine sulfenic acid (-SOH) intermediate

GO annotations

AspectTerm
Cellular Componentchloroplast
Cellular Componentcytosol
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular Functionthioredoxin peroxidase activity
Biological Processcellular response to oxidative stress

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Peroxiredoxin-2B
  • EC number
  • Alternative names
    • Glutaredoxin-dependent peroxiredoxin
    • Peroxiredoxin IIB
    • Peroxiredoxin TPx1
    • Thioredoxin peroxidase 2B
    • Thioredoxin-dependent peroxidase 1

Gene names

    • Name
      PRXIIB
    • Synonyms
      TPX1
    • ORF names
      F12P19.14
    • Ordered locus names
      At1g65980

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9XEX2

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002822791-162Peroxiredoxin-2B

Proteomic databases

Expression

Tissue specificity

Expressed in all tissues but mostly in reproductive tissues such as buds, flowers, siliques and seeds.

Induction

Slightly induced by salt stress.

Gene expression databases

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-162Thioredoxin

Sequence similarities

Belongs to the peroxiredoxin family. Prx5 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete

This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.

Q9XEX2-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    162
  • Mass (Da)
    17,428
  • Last updated
    1999-11-01 v1
  • MD5 Checksum
    F9D2BD24A3486D23643C2ECF119F0C65
MAPIAVGDVVPDGTISFFDENDQLQTASVHSLAAGKKVILFGVPGAFTPTCSMKHVPGFIEKAEELKSKGVDEIICFSVNDPFVMKAWGKTYPENKHVKFVADGSGEYTHLLGLELDLKDKGLGVRSRRFALLLDDLKVTVANVESGGEFTVSSADDILKAL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F4ID64F4ID64_ARATHTPX187

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF121355
EMBL· GenBank· DDBJ
AAD28242.1
EMBL· GenBank· DDBJ
mRNA
AC009513
EMBL· GenBank· DDBJ
AAF06058.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE34447.1
EMBL· GenBank· DDBJ
Genomic DNA
AF332464
EMBL· GenBank· DDBJ
AAG48827.1
EMBL· GenBank· DDBJ
mRNA
AY065056
EMBL· GenBank· DDBJ
AAL57690.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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