Q9XER9 · HUA2_ARATH

Function

function

Transcription factor that functions as a repressor of flowering by enhancing the expression of several genes that delay flowering including FLC, FLM/MAF1, MAF2 and SVP (PubMed:15659097).
Also acts in the floral homeotic AGAMOUS (AG) pathway, specifically by processing the AGAMOUS pre-mRNA (PubMed:10198637, PubMed:12530963).
Functions in association with HUA1 and HEN4 in AG pre-mRNA processing (PubMed:12530963).
Involved in all three aspects of the AG functions, the specification of stamen and carpel identities, the control of floral determinacy, and the spatial restriction of AP1 expression (PubMed:10198637, PubMed:12530963, PubMed:15659097).
Acts as a transcription regulator that controls anthocyanin accumulation (PubMed:25425527).

Miscellaneous

In cv. Sy-0, a naturally occurring allele K525E, termed ART1, together with active FRI and FLC alleles causes delayed flowering of primary and axillary meristems, resulting in the distinctive Sy-0 morphology (PubMed:17764945).

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity
Biological Processanthocyanin accumulation in tissues in response to UV light
Biological Processcell differentiation
Biological Processmaintenance of floral organ identity
Biological ProcessmRNA processing
Biological Processnegative regulation of flower development
Biological Processregulation of timing of transition from vegetative to reproductive phase

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ENHANCER OF AG-4 protein 2
  • Alternative names
    • Protein AERIAL ROSETTE 1

Gene names

    • Name
      HUA2
    • Synonyms
      ART1
    • ORF names
      MKD15, MYJ24.14
    • Ordered locus names
      At5g23150

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9XER9

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Hua2 mutations enhance the phenotype of mild ag-4 and elf4 alleles and also induce early flowering by reducing the expression of several MADS genes that act as floral repressors like FLC, FLM/MAF1, MAF2 and SVP.

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant525in strain: cv. Sy-0; causes late flowering phenotype

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 142 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004188561-1392ENHANCER OF AG-4 protein 2

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the inflorescence meristem, floral primordia, inflorescence stem, and floral pedicels. Also detected in the shoot apical meristem, stems, leaves, embryos, and roots.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain20-77PWWP
Compositional bias184-198Polar residues
Region184-354Disordered
Compositional bias200-217Basic and acidic residues
Compositional bias233-260Basic and acidic residues
Compositional bias261-276Polar residues
Compositional bias277-295Basic and acidic residues
Compositional bias305-347Basic and acidic residues
Region384-428Disordered
Compositional bias387-402Polar residues
Compositional bias404-418Basic and acidic residues
Region575-613Disordered
Compositional bias588-608Polar residues
Compositional bias723-741Polar residues
Region723-766Disordered
Compositional bias742-758Basic and acidic residues
Domain771-912CID
Region957-986Disordered
Region1014-1356Disordered
Compositional bias1058-1131Pro residues
Compositional bias1159-1185Polar residues
Compositional bias1200-1287Polar residues
Compositional bias1292-1306Basic and acidic residues
Region1369-1392Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,392
  • Mass (Da)
    151,078
  • Last updated
    1999-11-01 v1
  • Checksum
    D2AC1B0D2AA70F0F
MAPGRKRGASKAKAKGQLVLGDLVLAKVKGFPAWPAKISRPEDWDRAPDPKKYFVQFFGTEEIAFVAPPDIQAFTSEAKSKLLARCQGKTVKYFAQAVEQICTAFEGLQNHKSNALGDEDSLDATEPGLTKAEIVDGTDHIVIESERTDNFNFRVDPCFPKLDENNGEERKAEIRKLDSSSFLESKVKTTSPVSESLEHSSFDPKIKKEDFDKGTDGSACNEHFGNGQKKLANGKRIKKEAGGSDRKGEDTVHRDKSNNSHVPGGRTASGNSDSKKSKGLLTEKTSSKVSADKHENSPGIKVGVSGKKRRLESEQGKLAPRVDESSRAAKKPRCESADNKVKCEIDDGSDSTGTVSDIKREIVLGLGARGGNFQYDKEAVAYTKRQRQTMEHATSPSFSGSRDKSGKGHLEQKDRSSPVRNVKAPAAQSLKKRRAVCIYDEDDDEDPKTPLHGKPAIVPQAASVLTDGPKRANVCHSTSTKAKISAGSTESTEVRKFPLRKHCEDASRVLPSNAENSTNSLPVVKPINELPPKDVKQILQSPKMSPQLVLTNKHVAGQHKVVKSSVKVSGVVMAKKPQSDSCKEAVAGSDKISSSQSQPANQRHKSASVGERLTVVSKAASRLNDSGSRDMSEDLSAAMLDLNREKGSATFTSAKTPDSAASMKDLIAAAQAKRKLAHTQNSIFGNLNPSFLSISDTQGRSHSPFMVQNASASAAISMPLVVQGHHQQGSSPSNHGHQSLSRNQIETDDNEERRLSSGHKSVGGSLSCSTEAAISRDAFEGMLETLSRTRESIGRATRLAIDCAKYGLASEVVELLIRKLESESHFHRKVDLFFLVDSITQHSHSQKGIAGASYVPTVQAALPRLLGAAAPPGTGASDNRRKCLKVLKLWLERKVFPESLLRRYIDDIRASGDDATGGFSLRRPSRSERAVDDPIREMEGMLVDEYGSNATFQLPGFFSSHNFEDDEEDDDLPTSQKEKSTSAGERVSALDDLEIHDTSSDKCHRVLEDVDHELEMEDVSGQRKDVAPSSFCENKTKEQSLDVMEPVAEKSTEFNPLPEDSPPLPQESPPPLPPLPPSPPPPSPPLPPSSLPPPPPAALFPPLPPPPSQPPPPPLSPPPSPPPPPPPPSQSLTTQLSIASHHQIPFQPGFPPPTYPLSHQTYPGSMQQDRSSIFTGDQIVQGPGNSSRGGLVEGAGKPEYFVQQSSSFSPAGVCSSREPSSFTSSRQLEFGNSDVLFNPEASSQNHRFQPSTPLSQRPMVRLPSAPSSHFSYPSHIQSQSQHSYTHPYPFPPQRDDARRYRNEEPWRIPSSGHSAENQNGAWIHGRNSHPGLPRVTDSFFRPPPERPPSGTMNYQPSAASNLQAVPAIPGHTAPQMLPSRPDIPTVNCWRPA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1P8BC24A0A1P8BC24_ARATHHUA21339

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias184-198Polar residues
Compositional bias200-217Basic and acidic residues
Compositional bias233-260Basic and acidic residues
Compositional bias261-276Polar residues
Compositional bias277-295Basic and acidic residues
Compositional bias305-347Basic and acidic residues
Compositional bias387-402Polar residues
Compositional bias404-418Basic and acidic residues
Compositional bias588-608Polar residues
Compositional bias723-741Polar residues
Compositional bias742-758Basic and acidic residues
Compositional bias1058-1131Pro residues
Compositional bias1159-1185Polar residues
Compositional bias1200-1287Polar residues
Compositional bias1292-1306Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF116556
EMBL· GenBank· DDBJ
AAD31171.1
EMBL· GenBank· DDBJ
mRNA
AB007648
EMBL· GenBank· DDBJ
BAB11170.1
EMBL· GenBank· DDBJ
Genomic DNA
AB006708
EMBL· GenBank· DDBJ
BAB11170.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED93127.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
ANM69147.1
EMBL· GenBank· DDBJ
Genomic DNA
AB493755
EMBL· GenBank· DDBJ
BAH30593.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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