Q9XER9 · HUA2_ARATH
- ProteinENHANCER OF AG-4 protein 2
- GeneHUA2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1392 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Transcription factor that functions as a repressor of flowering by enhancing the expression of several genes that delay flowering including FLC, FLM/MAF1, MAF2 and SVP (PubMed:15659097).
Also acts in the floral homeotic AGAMOUS (AG) pathway, specifically by processing the AGAMOUS pre-mRNA (PubMed:10198637, PubMed:12530963).
Functions in association with HUA1 and HEN4 in AG pre-mRNA processing (PubMed:12530963).
Involved in all three aspects of the AG functions, the specification of stamen and carpel identities, the control of floral determinacy, and the spatial restriction of AP1 expression (PubMed:10198637, PubMed:12530963, PubMed:15659097).
Acts as a transcription regulator that controls anthocyanin accumulation (PubMed:25425527).
Also acts in the floral homeotic AGAMOUS (AG) pathway, specifically by processing the AGAMOUS pre-mRNA (PubMed:10198637, PubMed:12530963).
Functions in association with HUA1 and HEN4 in AG pre-mRNA processing (PubMed:12530963).
Involved in all three aspects of the AG functions, the specification of stamen and carpel identities, the control of floral determinacy, and the spatial restriction of AP1 expression (PubMed:10198637, PubMed:12530963, PubMed:15659097).
Acts as a transcription regulator that controls anthocyanin accumulation (PubMed:25425527).
Miscellaneous
In cv. Sy-0, a naturally occurring allele K525E, termed ART1, together with active FRI and FLC alleles causes delayed flowering of primary and axillary meristems, resulting in the distinctive Sy-0 morphology (PubMed:17764945).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity | |
Biological Process | anthocyanin accumulation in tissues in response to UV light | |
Biological Process | cell differentiation | |
Biological Process | maintenance of floral organ identity | |
Biological Process | mRNA processing | |
Biological Process | negative regulation of flower development | |
Biological Process | regulation of timing of transition from vegetative to reproductive phase |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameENHANCER OF AG-4 protein 2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9XER9
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Hua2 mutations enhance the phenotype of mild ag-4 and elf4 alleles and also induce early flowering by reducing the expression of several MADS genes that act as floral repressors like FLC, FLM/MAF1, MAF2 and SVP.
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 525 | in strain: cv. Sy-0; causes late flowering phenotype | ||||
Sequence: K → E |
Variants

We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 142 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000418856 | 1-1392 | ENHANCER OF AG-4 protein 2 | |||
Sequence: MAPGRKRGASKAKAKGQLVLGDLVLAKVKGFPAWPAKISRPEDWDRAPDPKKYFVQFFGTEEIAFVAPPDIQAFTSEAKSKLLARCQGKTVKYFAQAVEQICTAFEGLQNHKSNALGDEDSLDATEPGLTKAEIVDGTDHIVIESERTDNFNFRVDPCFPKLDENNGEERKAEIRKLDSSSFLESKVKTTSPVSESLEHSSFDPKIKKEDFDKGTDGSACNEHFGNGQKKLANGKRIKKEAGGSDRKGEDTVHRDKSNNSHVPGGRTASGNSDSKKSKGLLTEKTSSKVSADKHENSPGIKVGVSGKKRRLESEQGKLAPRVDESSRAAKKPRCESADNKVKCEIDDGSDSTGTVSDIKREIVLGLGARGGNFQYDKEAVAYTKRQRQTMEHATSPSFSGSRDKSGKGHLEQKDRSSPVRNVKAPAAQSLKKRRAVCIYDEDDDEDPKTPLHGKPAIVPQAASVLTDGPKRANVCHSTSTKAKISAGSTESTEVRKFPLRKHCEDASRVLPSNAENSTNSLPVVKPINELPPKDVKQILQSPKMSPQLVLTNKHVAGQHKVVKSSVKVSGVVMAKKPQSDSCKEAVAGSDKISSSQSQPANQRHKSASVGERLTVVSKAASRLNDSGSRDMSEDLSAAMLDLNREKGSATFTSAKTPDSAASMKDLIAAAQAKRKLAHTQNSIFGNLNPSFLSISDTQGRSHSPFMVQNASASAAISMPLVVQGHHQQGSSPSNHGHQSLSRNQIETDDNEERRLSSGHKSVGGSLSCSTEAAISRDAFEGMLETLSRTRESIGRATRLAIDCAKYGLASEVVELLIRKLESESHFHRKVDLFFLVDSITQHSHSQKGIAGASYVPTVQAALPRLLGAAAPPGTGASDNRRKCLKVLKLWLERKVFPESLLRRYIDDIRASGDDATGGFSLRRPSRSERAVDDPIREMEGMLVDEYGSNATFQLPGFFSSHNFEDDEEDDDLPTSQKEKSTSAGERVSALDDLEIHDTSSDKCHRVLEDVDHELEMEDVSGQRKDVAPSSFCENKTKEQSLDVMEPVAEKSTEFNPLPEDSPPLPQESPPPLPPLPPSPPPPSPPLPPSSLPPPPPAALFPPLPPPPSQPPPPPLSPPPSPPPPPPPPSQSLTTQLSIASHHQIPFQPGFPPPTYPLSHQTYPGSMQQDRSSIFTGDQIVQGPGNSSRGGLVEGAGKPEYFVQQSSSFSPAGVCSSREPSSFTSSRQLEFGNSDVLFNPEASSQNHRFQPSTPLSQRPMVRLPSAPSSHFSYPSHIQSQSQHSYTHPYPFPPQRDDARRYRNEEPWRIPSSGHSAENQNGAWIHGRNSHPGLPRVTDSFFRPPPERPPSGTMNYQPSAASNLQAVPAIPGHTAPQMLPSRPDIPTVNCWRPA |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the inflorescence meristem, floral primordia, inflorescence stem, and floral pedicels. Also detected in the shoot apical meristem, stems, leaves, embryos, and roots.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 20-77 | PWWP | ||||
Sequence: LGDLVLAKVKGFPAWPAKISRPEDWDRAPDPKKYFVQFFGTEEIAFVAPPDIQAFTSE | ||||||
Compositional bias | 184-198 | Polar residues | ||||
Sequence: ESKVKTTSPVSESLE | ||||||
Region | 184-354 | Disordered | ||||
Sequence: ESKVKTTSPVSESLEHSSFDPKIKKEDFDKGTDGSACNEHFGNGQKKLANGKRIKKEAGGSDRKGEDTVHRDKSNNSHVPGGRTASGNSDSKKSKGLLTEKTSSKVSADKHENSPGIKVGVSGKKRRLESEQGKLAPRVDESSRAAKKPRCESADNKVKCEIDDGSDSTGT | ||||||
Compositional bias | 200-217 | Basic and acidic residues | ||||
Sequence: SSFDPKIKKEDFDKGTDG | ||||||
Compositional bias | 233-260 | Basic and acidic residues | ||||
Sequence: NGKRIKKEAGGSDRKGEDTVHRDKSNNS | ||||||
Compositional bias | 261-276 | Polar residues | ||||
Sequence: HVPGGRTASGNSDSKK | ||||||
Compositional bias | 277-295 | Basic and acidic residues | ||||
Sequence: SKGLLTEKTSSKVSADKHE | ||||||
Compositional bias | 305-347 | Basic and acidic residues | ||||
Sequence: SGKKRRLESEQGKLAPRVDESSRAAKKPRCESADNKVKCEIDD | ||||||
Region | 384-428 | Disordered | ||||
Sequence: KRQRQTMEHATSPSFSGSRDKSGKGHLEQKDRSSPVRNVKAPAAQ | ||||||
Compositional bias | 387-402 | Polar residues | ||||
Sequence: RQTMEHATSPSFSGSR | ||||||
Compositional bias | 404-418 | Basic and acidic residues | ||||
Sequence: KSGKGHLEQKDRSSP | ||||||
Region | 575-613 | Disordered | ||||
Sequence: KKPQSDSCKEAVAGSDKISSSQSQPANQRHKSASVGERL | ||||||
Compositional bias | 588-608 | Polar residues | ||||
Sequence: GSDKISSSQSQPANQRHKSAS | ||||||
Compositional bias | 723-741 | Polar residues | ||||
Sequence: QGHHQQGSSPSNHGHQSLS | ||||||
Region | 723-766 | Disordered | ||||
Sequence: QGHHQQGSSPSNHGHQSLSRNQIETDDNEERRLSSGHKSVGGSL | ||||||
Compositional bias | 742-758 | Basic and acidic residues | ||||
Sequence: RNQIETDDNEERRLSSG | ||||||
Domain | 771-912 | CID | ||||
Sequence: EAAISRDAFEGMLETLSRTRESIGRATRLAIDCAKYGLASEVVELLIRKLESESHFHRKVDLFFLVDSITQHSHSQKGIAGASYVPTVQAALPRLLGAAAPPGTGASDNRRKCLKVLKLWLERKVFPESLLRRYIDDIRASG | ||||||
Region | 957-986 | Disordered | ||||
Sequence: FFSSHNFEDDEEDDDLPTSQKEKSTSAGER | ||||||
Region | 1014-1356 | Disordered | ||||
Sequence: LEMEDVSGQRKDVAPSSFCENKTKEQSLDVMEPVAEKSTEFNPLPEDSPPLPQESPPPLPPLPPSPPPPSPPLPPSSLPPPPPAALFPPLPPPPSQPPPPPLSPPPSPPPPPPPPSQSLTTQLSIASHHQIPFQPGFPPPTYPLSHQTYPGSMQQDRSSIFTGDQIVQGPGNSSRGGLVEGAGKPEYFVQQSSSFSPAGVCSSREPSSFTSSRQLEFGNSDVLFNPEASSQNHRFQPSTPLSQRPMVRLPSAPSSHFSYPSHIQSQSQHSYTHPYPFPPQRDDARRYRNEEPWRIPSSGHSAENQNGAWIHGRNSHPGLPRVTDSFFRPPPERPPSGTMNYQP | ||||||
Compositional bias | 1058-1131 | Pro residues | ||||
Sequence: PEDSPPLPQESPPPLPPLPPSPPPPSPPLPPSSLPPPPPAALFPPLPPPPSQPPPPPLSPPPSPPPPPPPPSQS | ||||||
Compositional bias | 1159-1185 | Polar residues | ||||
Sequence: HQTYPGSMQQDRSSIFTGDQIVQGPGN | ||||||
Compositional bias | 1200-1287 | Polar residues | ||||
Sequence: YFVQQSSSFSPAGVCSSREPSSFTSSRQLEFGNSDVLFNPEASSQNHRFQPSTPLSQRPMVRLPSAPSSHFSYPSHIQSQSQHSYTHP | ||||||
Compositional bias | 1292-1306 | Basic and acidic residues | ||||
Sequence: PQRDDARRYRNEEPW | ||||||
Region | 1369-1392 | Disordered | ||||
Sequence: PGHTAPQMLPSRPDIPTVNCWRPA |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,392
- Mass (Da)151,078
- Last updated1999-11-01 v1
- ChecksumD2AC1B0D2AA70F0F
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8BC24 | A0A1P8BC24_ARATH | HUA2 | 1339 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 184-198 | Polar residues | ||||
Sequence: ESKVKTTSPVSESLE | ||||||
Compositional bias | 200-217 | Basic and acidic residues | ||||
Sequence: SSFDPKIKKEDFDKGTDG | ||||||
Compositional bias | 233-260 | Basic and acidic residues | ||||
Sequence: NGKRIKKEAGGSDRKGEDTVHRDKSNNS | ||||||
Compositional bias | 261-276 | Polar residues | ||||
Sequence: HVPGGRTASGNSDSKK | ||||||
Compositional bias | 277-295 | Basic and acidic residues | ||||
Sequence: SKGLLTEKTSSKVSADKHE | ||||||
Compositional bias | 305-347 | Basic and acidic residues | ||||
Sequence: SGKKRRLESEQGKLAPRVDESSRAAKKPRCESADNKVKCEIDD | ||||||
Compositional bias | 387-402 | Polar residues | ||||
Sequence: RQTMEHATSPSFSGSR | ||||||
Compositional bias | 404-418 | Basic and acidic residues | ||||
Sequence: KSGKGHLEQKDRSSP | ||||||
Compositional bias | 588-608 | Polar residues | ||||
Sequence: GSDKISSSQSQPANQRHKSAS | ||||||
Compositional bias | 723-741 | Polar residues | ||||
Sequence: QGHHQQGSSPSNHGHQSLS | ||||||
Compositional bias | 742-758 | Basic and acidic residues | ||||
Sequence: RNQIETDDNEERRLSSG | ||||||
Compositional bias | 1058-1131 | Pro residues | ||||
Sequence: PEDSPPLPQESPPPLPPLPPSPPPPSPPLPPSSLPPPPPAALFPPLPPPPSQPPPPPLSPPPSPPPPPPPPSQS | ||||||
Compositional bias | 1159-1185 | Polar residues | ||||
Sequence: HQTYPGSMQQDRSSIFTGDQIVQGPGN | ||||||
Compositional bias | 1200-1287 | Polar residues | ||||
Sequence: YFVQQSSSFSPAGVCSSREPSSFTSSRQLEFGNSDVLFNPEASSQNHRFQPSTPLSQRPMVRLPSAPSSHFSYPSHIQSQSQHSYTHP | ||||||
Compositional bias | 1292-1306 | Basic and acidic residues | ||||
Sequence: PQRDDARRYRNEEPW |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF116556 EMBL· GenBank· DDBJ | AAD31171.1 EMBL· GenBank· DDBJ | mRNA | ||
AB007648 EMBL· GenBank· DDBJ | BAB11170.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB006708 EMBL· GenBank· DDBJ | BAB11170.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED93127.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | ANM69147.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB493755 EMBL· GenBank· DDBJ | BAH30593.1 EMBL· GenBank· DDBJ | mRNA |