Q9XC11 · FGD_MYCFO

Function

function

Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria.

Catalytic activity

Features

Showing features for binding site, active site.

133650100150200250300
TypeIDPosition(s)Description
Binding site39coenzyme F420-(gamma-Glu)n (UniProtKB | ChEBI)
Active site40Proton donor
Binding site76coenzyme F420-(gamma-Glu)n (UniProtKB | ChEBI)
Binding site107-108coenzyme F420-(gamma-Glu)n (UniProtKB | ChEBI)
Active site109Proton acceptor
Binding site112coenzyme F420-(gamma-Glu)n (UniProtKB | ChEBI)
Binding site177-178coenzyme F420-(gamma-Glu)n (UniProtKB | ChEBI)
Binding site180-181coenzyme F420-(gamma-Glu)n (UniProtKB | ChEBI)
Binding site195substrate
Binding site198substrate
Binding site259substrate
Binding site283substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functioncoenzyme F420 binding
Molecular Functionglucose-6-phosphate dehydrogenase (coenzyme F420) activity
Molecular Functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Biological Processcarbohydrate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    F420-dependent glucose-6-phosphate dehydrogenase
  • EC number
  • Short names
    FGD
    ; G6PD

Gene names

    • Name
      fgd

Organism names

Accessions

  • Primary accession
    Q9XC11

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004135931-336F420-dependent glucose-6-phosphate dehydrogenase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    336
  • Mass (Da)
    37,280
  • Last updated
    1999-11-01 v1
  • Checksum
    254E55B6414D9302
MAELKLGYKASAEQFAPRELVELAVLAEAAGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVGERTQRLVLGTSVLTPTFRYNPAVIAQAFATMGCLYPGRVFLGVGTGEALNEIATGYIGQWPEFKERFARLRESVKLMRELWLGDRVDFDGEYYKLRGASIYDVPEGGIPVYIAAGGPVVAKYAGRAGDGFICTSGKGEELYKDKLIPAVREGAEAAGRNAEDIDRMIEIKISYDPDPELALENTRFWAPLSLTPEQKHSIDDPIEMEKAADALPIEQVAKRWIVASDPDEAVEKVGQYVTWGLNHLVFHAPGHDQRRFLDLFKKDLEPRLRKLG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF152396
EMBL· GenBank· DDBJ
AAD38169.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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