Q9X0C6 · HIS6_THEMA

Function

function

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

Catalytic activity

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
1.5 μMPRFAR
2.2 mMNH3

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site11
Active site130

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionimidazoleglycerol-phosphate synthase activity
Molecular Functionlyase activity
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Imidazole glycerol phosphate synthase subunit HisF
  • EC number
  • Alternative names
    • IGP synthase cyclase subunit
    • IGP synthase subunit HisF
    • ImGP synthase subunit HisF (IGPS subunit HisF)

Gene names

    • Name
      hisF
    • Ordered locus names
      TM_1036

Organism names

Accessions

  • Primary accession
    Q9X0C6

Proteomes

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis9No change in activity.
Mutagenesis11Loss of activity.
Mutagenesis19Decrease in activity.
Mutagenesis51No change in activity.
Mutagenesis103No change in activity.
Mutagenesis130Complete loss of activity.
Mutagenesis130Weak activity.
Mutagenesis176Decrease in activity.
Mutagenesis183No change in activity.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001422531-253Imidazole glycerol phosphate synthase subunit HisF

Proteomic databases

Interaction

Subunit

Heterodimer of HisH and HisF.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9X0C6hisH Q9X0C82EBI-9026911, EBI-9026913

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HisA/HisF family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    253
  • Mass (Da)
    27,719
  • Last updated
    1999-11-01 v1
  • Checksum
    FE0F97F0C57E9025
MLAKRIIACLDVKDGRVVKGTNFENLRDSGDPVELGKFYSEIGIDELVFLDITASVEKRKTMLELVEKVAEQIDIPFTVGGGIHDFETASELILRGADKVSINTAAVENPSLITQIAQTFGSQAVVVAIDAKRVDGEFMVFTYSGKKNTGILLRDWVVEVEKRGAGEILLTSIDRDGTKSGYDTEMIRFVRPLTTLPIIASGGAGKMEHFLEAFLAGADAALAASVFHFREIDVRELKEYLKKHGVNVRLEGL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE000512
EMBL· GenBank· DDBJ
AAD36113.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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