Q9WZY5 · COAX_THEMA
- ProteinType III pantothenate kinase
- GenecoaX
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids246 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
Catalytic activity
- (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H+
Cofactor
K+ (UniProtKB | Rhea| CHEBI:29103 )
Note: A monovalent cation. Ammonium or potassium.
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
40 μM | pantothenate | 50 | ||||
6 mM | ATP | 50 |
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | pantothenate kinase activity | |
Biological Process | coenzyme A biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameType III pantothenate kinase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Thermotogota > Thermotogae > Thermotogales > Thermotogaceae > Thermotoga
Accessions
- Primary accessionQ9WZY5
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000267598 | 1-246 | Type III pantothenate kinase | |||
Sequence: MYLLVDVGNTHSVFSITEDGKTFRRWRLSTGVFQTEDELFSHLHPLLGDAMREIKGIGVASVVPTQNTVIERFSQKYFHISPIWVKAKNGCVKWNVKNPSEVGADRVANVVAFVKEYGKNGIIIDMGTATTVDLVVNGSYEGGAILPGFFMMVHSLFRGTAKLPLVEVKPADFVVGKDTEENIRLGVVNGSVYALEGIIGRIKEVYGDLPVVLTGGQSKIVKDMIKHEIFDEDLTIKGVYHFCFGD |
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length246
- Mass (Da)27,154
- Last updated1999-11-01 v1
- Checksum9E0309AD462CF266
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE000512 EMBL· GenBank· DDBJ | AAD35964.1 EMBL· GenBank· DDBJ | Genomic DNA |