Q9WZY5 · COAX_THEMA

Function

function

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.

Catalytic activity

Cofactor

NH4+ (UniProtKB | Rhea| CHEBI:28938 )

K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: A monovalent cation. Ammonium or potassium.

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
40 μMpantothenate50
6 mMATP50

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site6-13ATP (UniProtKB | ChEBI)
Binding site103-106substrate
Active site105Proton acceptor
Binding site125K+ (UniProtKB | ChEBI)
Binding site128ATP (UniProtKB | ChEBI)
Binding site179substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionpantothenate kinase activity
Biological Processcoenzyme A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Type III pantothenate kinase
  • EC number
  • Alternative names
    • PanK-III
    • Pantothenic acid kinase

Gene names

    • Name
      coaX
    • Ordered locus names
      TM_0883

Organism names

Accessions

  • Primary accession
    Q9WZY5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002675981-246Type III pantothenate kinase

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    246
  • Mass (Da)
    27,154
  • Last updated
    1999-11-01 v1
  • Checksum
    9E0309AD462CF266
MYLLVDVGNTHSVFSITEDGKTFRRWRLSTGVFQTEDELFSHLHPLLGDAMREIKGIGVASVVPTQNTVIERFSQKYFHISPIWVKAKNGCVKWNVKNPSEVGADRVANVVAFVKEYGKNGIIIDMGTATTVDLVVNGSYEGGAILPGFFMMVHSLFRGTAKLPLVEVKPADFVVGKDTEENIRLGVVNGSVYALEGIIGRIKEVYGDLPVVLTGGQSKIVKDMIKHEIFDEDLTIKGVYHFCFGD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE000512
EMBL· GenBank· DDBJ
AAD35964.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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