Q9WVR4 · FXR2_MOUSE

  • Protein
    RNA-binding protein FXR2
  • Gene
    Fxr2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (PubMed:21658585).
Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:21658585).
Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity).
Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (PubMed:21658585).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoplasmic stress granule
Cellular Componentdendrite
Cellular Componentglutamatergic synapse
Cellular Componentneuron projection
Cellular Componentnucleus
Cellular Componentpostsynapse
Cellular Componentpresynapse
Cellular Componentribosome
Molecular FunctionmRNA 3'-UTR binding
Molecular Functionprotein heterodimerization activity
Molecular Functionprotein homodimerization activity
Molecular Functiontranslation regulator activity
Biological Processanimal organ development
Biological Processdentate gyrus development
Biological ProcessmRNA destabilization
Biological ProcessmRNA transport
Biological Processpositive regulation of long-term neuronal synaptic plasticity
Biological Processpositive regulation of translation
Biological Processregulation of mRNA stability
Biological Processregulation of translation at presynapse, modulating synaptic transmission

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    RNA-binding protein FXR2
  • Short names
    FXR2P

Gene names

    • Name
      Fxr2
    • Synonyms
      Fxr2h

Organism names

  • Taxonomic identifier
  • Strain
    • 129
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9WVR4
  • Secondary accessions
    • Q9WVR5

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Postsynapse
Note: Specifically localizes to cytoplasmic ribonucleoprotein membraneless compartments (By similarity).
Localization to the post-synaptic region is dependent on FMR1 (PubMed:27770568).

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype; mice are viable and fertile and do not exhibit any overt phenotype (PubMed:11875043).
Mice however show behavioral abnormalities, characterized by hyperactivity (PubMed:11875043).
Increased proliferation of radial glia-like neural stem/progenitor cells in the adult dentate gyrus caused by increased Nog (Noggin) expression and subsequently reduced BMP signaling (PubMed:21658585).
Misregulation of a number of transcripts involved in memory or cognitions is observed in the brain of mutant mice (PubMed:18930145).
Mice lacking both Fxr2 and Fmr1 display exaggerated learning deficits, characterized by prepulse inhibition of acoustic startle response and contextual fear conditioning compared with single mutant (Fxr2 or Fmr1) mice (PubMed:16675531).

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000501111-673RNA-binding protein FXR2
Modified residue78Phosphotyrosine
Modified residue192Phosphoserine
Modified residue413Phosphothreonine
Modified residue452Phosphoserine
Modified residue455Phosphoserine
Modified residue465Phosphoserine
Modified residue534Phosphoserine
Modified residue567Phosphoserine
Modified residue581Phosphoserine
Modified residue599Phosphothreonine
Modified residue602Phosphoserine
Modified residue604Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in brain and testis (PubMed:11875043).
In brain, expressed in the subventricular zone of the lateral ventricles and in most of the granule neurons of the dentate gyrus of the hippocampus (PubMed:21658585).

Interaction

Subunit

Interacts with FMR1 (By similarity).
Interacts with FXR1 (By similarity).
Interacts with TDRD3 (By similarity).
Interacts with HABP4 (By similarity).
Interacts with CYFIP2 but not with CYFIP1 (PubMed:11438699).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain14-60Agenet-like 1
Domain73-125Agenet-like 2
Domain228-276KH 1
Domain291-340KH 2
Region388-673Disordered
Compositional bias409-427Polar residues
Compositional bias455-488Basic and acidic residues
Compositional bias501-524Polar residues
Compositional bias615-644Polar residues

Domain

The tandem Agenet-like domains preferentially recognize trimethylated histone peptides.
Disordered region at the C-terminus undergoes liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that stores mRNAs.

Sequence similarities

Belongs to the FMR1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    673
  • Mass (Da)
    73,743
  • Last updated
    1999-11-01 v1
  • Checksum
    01F6814D4C3B5654
MGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRANEQEPCGWCLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNSSSLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRDLVGKVTGKTGKVIQGIVDKSGVVRVRVEGDNDKKNPKEGGMVPFIFVGTRENISNAQALLEYHLSYLQEVETLRLERLQIDEQLRQIGAGFRPPGSGRGGSGGGSDKAGYTTDESSSSSLHTTRTYGGSYGGRGRGRRTGGPAYGPSSDPSTASETESEKREESNRAGPGDRDPPSRGEESRRRRLGPGKGPPPVPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGALESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSRQRPLGRTEPSEDSLSGQKGDSVSKLPKGPSENGELSAPLELGSLVNGVS

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A991EKZ2A0A991EKZ2_MOUSEFxr2749
Q6P5B5Q6P5B5_MOUSEFxr2674

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias409-427Polar residues
Compositional bias455-488Basic and acidic residues
Compositional bias501-524Polar residues
Compositional bias615-644Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB025269
EMBL· GenBank· DDBJ
BAA82147.1
EMBL· GenBank· DDBJ
mRNA
AB025311
EMBL· GenBank· DDBJ
BAA82249.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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