Q9WVR4 · FXR2_MOUSE
- ProteinRNA-binding protein FXR2
- GeneFxr2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids673 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (PubMed:21658585).
Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:21658585).
Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity).
Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (PubMed:21658585).
Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:21658585).
Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity).
Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (PubMed:21658585).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytoplasmic stress granule | |
Cellular Component | dendrite | |
Cellular Component | glutamatergic synapse | |
Cellular Component | neuron projection | |
Cellular Component | nucleus | |
Cellular Component | postsynapse | |
Cellular Component | presynapse | |
Cellular Component | ribosome | |
Molecular Function | mRNA 3'-UTR binding | |
Molecular Function | protein heterodimerization activity | |
Molecular Function | protein homodimerization activity | |
Molecular Function | translation regulator activity | |
Biological Process | animal organ development | |
Biological Process | dentate gyrus development | |
Biological Process | mRNA destabilization | |
Biological Process | mRNA transport | |
Biological Process | positive regulation of long-term neuronal synaptic plasticity | |
Biological Process | positive regulation of translation | |
Biological Process | regulation of mRNA stability | |
Biological Process | regulation of translation at presynapse, modulating synaptic transmission |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameRNA-binding protein FXR2
- Short namesFXR2P
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9WVR4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Specifically localizes to cytoplasmic ribonucleoprotein membraneless compartments (By similarity).
Localization to the post-synaptic region is dependent on FMR1 (PubMed:27770568).
Localization to the post-synaptic region is dependent on FMR1 (PubMed:27770568).
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
No visible phenotype; mice are viable and fertile and do not exhibit any overt phenotype (PubMed:11875043).
Mice however show behavioral abnormalities, characterized by hyperactivity (PubMed:11875043).
Increased proliferation of radial glia-like neural stem/progenitor cells in the adult dentate gyrus caused by increased Nog (Noggin) expression and subsequently reduced BMP signaling (PubMed:21658585).
Misregulation of a number of transcripts involved in memory or cognitions is observed in the brain of mutant mice (PubMed:18930145).
Mice lacking both Fxr2 and Fmr1 display exaggerated learning deficits, characterized by prepulse inhibition of acoustic startle response and contextual fear conditioning compared with single mutant (Fxr2 or Fmr1) mice (PubMed:16675531).
Mice however show behavioral abnormalities, characterized by hyperactivity (PubMed:11875043).
Increased proliferation of radial glia-like neural stem/progenitor cells in the adult dentate gyrus caused by increased Nog (Noggin) expression and subsequently reduced BMP signaling (PubMed:21658585).
Misregulation of a number of transcripts involved in memory or cognitions is observed in the brain of mutant mice (PubMed:18930145).
Mice lacking both Fxr2 and Fmr1 display exaggerated learning deficits, characterized by prepulse inhibition of acoustic startle response and contextual fear conditioning compared with single mutant (Fxr2 or Fmr1) mice (PubMed:16675531).
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000050111 | 1-673 | RNA-binding protein FXR2 | |||
Sequence: MGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRANEQEPCGWCLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNSSSLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRDLVGKVTGKTGKVIQGIVDKSGVVRVRVEGDNDKKNPKEGGMVPFIFVGTRENISNAQALLEYHLSYLQEVETLRLERLQIDEQLRQIGAGFRPPGSGRGGSGGGSDKAGYTTDESSSSSLHTTRTYGGSYGGRGRGRRTGGPAYGPSSDPSTASETESEKREESNRAGPGDRDPPSRGEESRRRRLGPGKGPPPVPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGALESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSRQRPLGRTEPSEDSLSGQKGDSVSKLPKGPSENGELSAPLELGSLVNGVS | ||||||
Modified residue | 78 | Phosphotyrosine | ||||
Sequence: Y | ||||||
Modified residue | 192 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 413 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 452 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 455 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 465 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 534 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 567 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 581 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 599 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 602 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 604 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 14-60 | Agenet-like 1 | ||||
Sequence: LPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLP | ||||||
Domain | 73-125 | Agenet-like 2 | ||||
Sequence: DEVEVYSRANEQEPCGWCLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPV | ||||||
Domain | 228-276 | KH 1 | ||||
Sequence: AFQEEFTVREDLMGLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYG | ||||||
Domain | 291-340 | KH 2 | ||||
Sequence: FSEDSVQVPRDLVGKVTGKTGKVIQGIVDKSGVVRVRVEGDNDKKNPKEG | ||||||
Region | 388-673 | Disordered | ||||
Sequence: IGAGFRPPGSGRGGSGGGSDKAGYTTDESSSSSLHTTRTYGGSYGGRGRGRRTGGPAYGPSSDPSTASETESEKREESNRAGPGDRDPPSRGEESRRRRLGPGKGPPPVPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGALESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSRQRPLGRTEPSEDSLSGQKGDSVSKLPKGPSENGELSAPLELGSLVNGVS | ||||||
Compositional bias | 409-427 | Polar residues | ||||
Sequence: AGYTTDESSSSSLHTTRTY | ||||||
Compositional bias | 455-488 | Basic and acidic residues | ||||
Sequence: SETESEKREESNRAGPGDRDPPSRGEESRRRRLG | ||||||
Compositional bias | 501-524 | Polar residues | ||||
Sequence: SRYNSSSISSVLKDPDSNPYSLLD | ||||||
Compositional bias | 615-644 | Polar residues | ||||
Sequence: YISRAESQSRQRPLGRTEPSEDSLSGQKGD |
Domain
The tandem Agenet-like domains preferentially recognize trimethylated histone peptides.
Disordered region at the C-terminus undergoes liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that stores mRNAs.
Sequence similarities
Belongs to the FMR1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length673
- Mass (Da)73,743
- Last updated1999-11-01 v1
- Checksum01F6814D4C3B5654
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A991EKZ2 | A0A991EKZ2_MOUSE | Fxr2 | 749 | ||
Q6P5B5 | Q6P5B5_MOUSE | Fxr2 | 674 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 409-427 | Polar residues | ||||
Sequence: AGYTTDESSSSSLHTTRTY | ||||||
Compositional bias | 455-488 | Basic and acidic residues | ||||
Sequence: SETESEKREESNRAGPGDRDPPSRGEESRRRRLG | ||||||
Compositional bias | 501-524 | Polar residues | ||||
Sequence: SRYNSSSISSVLKDPDSNPYSLLD | ||||||
Compositional bias | 615-644 | Polar residues | ||||
Sequence: YISRAESQSRQRPLGRTEPSEDSLSGQKGD |
Keywords
- Technical term