Q9WVG7 · OSR1_MOUSE

  • Protein
    Protein odd-skipped-related 1
  • Gene
    Osr1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell cortex
Cellular Componentcytosol
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding
Biological Processcell differentiation
Biological Processcell proliferation involved in kidney development
Biological Processcellular response to retinoic acid
Biological Processchondrocyte differentiation
Biological Processembryonic digit morphogenesis
Biological Processembryonic forelimb morphogenesis
Biological Processembryonic hindlimb morphogenesis
Biological Processembryonic skeletal joint development
Biological Processembryonic skeletal joint morphogenesis
Biological Processembryonic skeletal limb joint morphogenesis
Biological Processgonad development
Biological Processheart development
Biological Processintermediate mesoderm development
Biological Processmesangial cell development
Biological Processmesonephric duct morphogenesis
Biological Processmesonephros development
Biological Processmetanephric cap mesenchymal cell proliferation involved in metanephros development
Biological Processmetanephric epithelium development
Biological Processmetanephric glomerulus vasculature development
Biological Processmetanephric interstitial fibroblast development
Biological Processmetanephric mesenchymal cell differentiation
Biological Processmetanephric mesenchyme development
Biological Processmetanephric mesenchyme morphogenesis
Biological Processmetanephric nephron tubule development
Biological Processmetanephric smooth muscle tissue development
Biological Processmetanephros development
Biological Processmiddle ear morphogenesis
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of epithelial cell differentiation
Biological Processnegative regulation of nephron tubule epithelial cell differentiation
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processodontogenesis
Biological Processpattern specification involved in metanephros development
Biological Processpositive regulation of bone mineralization
Biological Processpositive regulation of epithelial cell proliferation
Biological Processpositive regulation of gastrulation
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processposterior mesonephric tubule development
Biological Processpronephros development
Biological Processregulation of transcription by RNA polymerase II
Biological Processrenal vesicle progenitor cell differentiation
Biological Processroof of mouth development
Biological Processsodium ion transmembrane transport
Biological Processspecification of anterior mesonephric tubule identity
Biological Processspecification of posterior mesonephric tubule identity
Biological Processstem cell differentiation
Biological Processureter urothelium development
Biological Processureteric bud development
Biological Processurogenital system development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein odd-skipped-related 1

Gene names

    • Name
      Osr1
    • Synonyms
      Odd1

Organism names

  • Taxonomic identifier
  • Strain
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9WVG7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Mice die prenatally with severe heart defects including defective atrioventricular junction and venous valves. They never initiate metanephric kidney formation. Nephrogenic mesenchyme undergo massive apoptosis, which causes a disruption of nephric duct elongation and failure of metanephric induction.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 10 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000470051-266
Modified residue116Asymmetric dimethylarginine

Keywords

Proteomic databases

PTM databases

Expression

Induction

Transcriptionally regulated by Ikzf1 and Runx2.

Developmental stage

During early embryogenesis it is expressed in the intermediate mesoderm and in a dynamic pattern during limb and branchial arch development. Is expressed from the earliest stage of intermediate development. Is expressed in the dorsal atrial wall, including the developing primary atrial septum and the venous valve.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for zinc finger.

TypeIDPosition(s)Description
Zinc finger175-197C2H2-type 1
Zinc finger203-225C2H2-type 2
Zinc finger231-253C2H2-type 3

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    266
  • Mass (Da)
    29,584
  • Last updated
    1999-11-01 v1
  • Checksum
    CC9948ACFC90F7A5
MGSKTLPAPVPIHPSLQLTNYSFLQAVNGLPTVPSDHLPNLYGFSALHAVHLHQWTLGYPAMHLPRSSFSKVPGAVSSLMDARFQLPAFPWFPHVIHPKPEITAGGSGAALKTKPRFDFANLALAATQEDPTKLGRGEGPGSPAGGLGALLDVTKLSPEKKPTRGRLPSKTKKEFVCKFCGRHFTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDHRYIHSKEKPFKCQECGKGFCQSRTLAVHKTLHSQVKELKTSKIKC

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1W2P7S2A0A1W2P7S2_MOUSEOsr1161

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF117814
EMBL· GenBank· DDBJ
AAD37115.1
EMBL· GenBank· DDBJ
mRNA
BC023922
EMBL· GenBank· DDBJ
AAH23922.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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