Q9WVF9 · CLC2I_MOUSE

  • Protein
    C-type lectin domain family 2 member I
  • Gene
    Clec2i
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Inhibits osteoclast formation. Receptor for KLRB1F. Enhances T-cell activation. Plays a role in splenocyte activation, T-cell responses and IL-2 production.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentexternal side of plasma membrane
Molecular Functioncarbohydrate binding
Molecular Functionnatural killer cell lectin-like receptor binding
Molecular Functiontransmembrane signaling receptor activity
Biological Processmembrane raft assembly
Biological Processnegative regulation of osteoclast differentiation
Biological Processpositive regulation of immunological synapse formation
Biological Processreceptor clustering
Biological Processregulation of actin filament polymerization
Biological Processregulation of interleukin-2 production
Biological Processregulation of T cell proliferation
Biological ProcessT cell receptor signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    C-type lectin domain family 2 member I
  • Alternative names
    • C-type lectin-related protein DCL1
    • C-type lectin-related protein G (Clr-g)
    • Lymphoid-derived C-type lectin-1 (LCL-1)
    • Osteoclast inhibitory lectin-related protein 2 (Ocil-related protein 2)

Gene names

    • Name
      Clec2i
    • Synonyms
      Clrg, Dcl1, Ocilrp2

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • 129/Sv
    • BALB/cJ
    • BALB/cByJ
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9WVF9
  • Secondary accessions
    • Q1AFZ2
    • Q7TSP6
    • Q7TSP7
    • Q8BFR3
    • Q924B1

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type II membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-53Cytoplasmic
Transmembrane54-74Helical; Signal-anchor for type II membrane protein
Topological domain75-217Extracellular

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00003152911-217C-type lectin domain family 2 member I
Disulfide bond92↔103
Glycosylation112N-linked (GlcNAc...) asparagine
Disulfide bond120↔202

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Detected in osteoblasts, growth plate chondrocytes and skeletal muscle overlying the bone (at protein level). Detected in spleen, B-cells, dendritic cells, thymus, and in IL2-activated natural killer cells.

Induction

Up-regulated in CD4+ T-cells upon stimulation with CD3-ligands. Up-regulated in cultured calvarial osteoblasts by 1,25-dihydroxyvitamin D3. Constitutively expressed in cultured bone marrow cells during osteoclast formation.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain99-203C-type lectin

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q9WVF9-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    217
  • Mass (Da)
    24,671
  • Last updated
    1999-11-01 v1
  • Checksum
    28D497A39F05DCD8
MPDCLETGEKLFVHNMNAQCVQKPEEGNGPLGTGGKIVQGKCFRIISTVSPVKLYCCYGVIMVLTVAVIALSVALSTKKTEQIIINKTYAACSKNWTGVGNKCFYFSGYPRNWTFAQAFCMAQEAQLARFDNEEELIFLKRFKGDFDCWIGLHRESSEHPWKWTNNTEYNNMNPILGVGRYAYLSSDRISSSRSYINRMWICSKLNNYNLHCQTPPV

Q9WVF9-2

  • Name
    2
  • Synonyms
    Lymphoid-derived C-type lectin-1b, LCL-1b
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9WVF9-3

  • Name
    3
  • Synonyms
    Lymphoid-derived C-type lectin-1a, LCL-1a
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9WVF9-4

  • Name
    4
  • Synonyms
    Lymphoid-derived C-type lectin-1c, LCL-1c
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
E0CX52E0CX52_MOUSEClec2i246

Sequence caution

The sequence AAK70359.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0305311-15in isoform 3
Alternative sequenceVSP_0305301-61in isoform 4
Alternative sequenceVSP_03053235in isoform 2 and isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF350411
EMBL· GenBank· DDBJ
AAK70359.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AY137343
EMBL· GenBank· DDBJ
AAN15951.1
EMBL· GenBank· DDBJ
Genomic DNA
AY137343
EMBL· GenBank· DDBJ
AAN15952.1
EMBL· GenBank· DDBJ
Genomic DNA
AY137344
EMBL· GenBank· DDBJ
AAN15953.1
EMBL· GenBank· DDBJ
mRNA
AY137345
EMBL· GenBank· DDBJ
AAN15954.1
EMBL· GenBank· DDBJ
mRNA
AY256574
EMBL· GenBank· DDBJ
AAP32744.1
EMBL· GenBank· DDBJ
mRNA
AY256575
EMBL· GenBank· DDBJ
AAP32745.1
EMBL· GenBank· DDBJ
mRNA
AY256576
EMBL· GenBank· DDBJ
AAP32746.1
EMBL· GenBank· DDBJ
mRNA
AF121352
EMBL· GenBank· DDBJ
AAD22055.1
EMBL· GenBank· DDBJ
mRNA
DQ143112
EMBL· GenBank· DDBJ
ABA43362.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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