Q9WVC8 · S26A3_MOUSE
- ProteinChloride anion exchanger
- GeneSlc26a3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids757 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:10428871).
Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:21976599).
Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:21976599).
Catalytic activity
- 2 chloride(out) + hydrogencarbonate(in) = 2 chloride(in) + hydrogencarbonate(out)
2 chloride (out)CHEBI:17996+ hydrogencarbonate (in)CHEBI:17544= 2 chloride (in)CHEBI:17996+ hydrogencarbonate (out)CHEBI:17544
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | brush border membrane | |
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Cellular Component | sperm midpiece | |
Molecular Function | bicarbonate transmembrane transporter activity | |
Molecular Function | chloride transmembrane transporter activity | |
Molecular Function | chloride:bicarbonate antiporter activity | |
Molecular Function | oxalate transmembrane transporter activity | |
Molecular Function | secondary active sulfate transmembrane transporter activity | |
Molecular Function | sulfate transmembrane transporter activity | |
Biological Process | cellular response to cAMP | |
Biological Process | intracellular pH elevation | |
Biological Process | membrane hyperpolarization | |
Biological Process | sperm capacitation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameChloride anion exchanger
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9WVC8
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Cell membrane ; Multi-pass membrane protein
Note: Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-71 | Cytoplasmic | ||||
Sequence: MIEAIGNQYVVARPVYSTKTFGEEFKKTHRHHKTFLDHLKGCCSCSSQKAKKIALSLFPIASWLPAYKIKE | ||||||
Transmembrane | 72-92 | Helical | ||||
Sequence: WLLSDIVSGISTGLVAVLQGL | ||||||
Topological domain | 93 | Extracellular | ||||
Sequence: A | ||||||
Transmembrane | 94-114 | Helical | ||||
Sequence: FALLVNIPPAYGLYAAFFPVI | ||||||
Topological domain | 115-124 | Cytoplasmic | ||||
Sequence: TYFFLGTSRH | ||||||
Transmembrane | 125-145 | Helical | ||||
Sequence: ISVGPFPVLSMMVGVVVTRVV | ||||||
Topological domain | 146-176 | Extracellular | ||||
Sequence: SDPNASSELSSSSTENDSFIEEKVMVAASVT | ||||||
Transmembrane | 177-197 | Helical | ||||
Sequence: VLSGIIQLLLGVLQVGFVVIY | ||||||
Topological domain | 198-201 | Cytoplasmic | ||||
Sequence: LSES | ||||||
Transmembrane | 202-222 | Helical | ||||
Sequence: LISGFTTAAAIHVLVSQLKFM | ||||||
Topological domain | 223-250 | Extracellular | ||||
Sequence: LQLPVPAYSDPFSIFKVLESVFTQIQKT | ||||||
Transmembrane | 251-271 | Helical | ||||
Sequence: NIADLVTSVIILVVVFVFKEI | ||||||
Topological domain | 272-278 | Cytoplasmic | ||||
Sequence: NQRYRSK | ||||||
Transmembrane | 279-299 | Helical | ||||
Sequence: LPVPIPIELIMTVIATGVSYG | ||||||
Topological domain | 300-335 | Extracellular | ||||
Sequence: CNFEDRFGVAVVGNMSLGFQPPITPSVEVFQDTIGD | ||||||
Transmembrane | 336-356 | Helical | ||||
Sequence: SFGIAIVGFAVAFSVASVYSL | ||||||
Topological domain | 357-367 | Cytoplasmic | ||||
Sequence: KYDYPIDGNQE | ||||||
Transmembrane | 368-388 | Helical | ||||
Sequence: LIALGVSNIFTGAFKGFAGST | ||||||
Topological domain | 389-404 | Extracellular | ||||
Sequence: ALSRSGVQESTGGKTQ | ||||||
Transmembrane | 405-425 | Helical | ||||
Sequence: VAGLLSAVIVLIVIVAIGFLL | ||||||
Topological domain | 426-462 | Cytoplasmic | ||||
Sequence: QPLQKSVLAALALGNLKGMLMQFAEIGRLWKKDKYDC | ||||||
Transmembrane | 463-483 | Helical | ||||
Sequence: LIWIMTFIFAIVLGLGLGLAA | ||||||
Topological domain | 484-757 | Extracellular | ||||
Sequence: SVAFQLLTIVFRTQFPKCSTLANVGRSNIYKNKKNYAEVYEPEGVKIFRCPSPIYFANIGFFKQKLIDAVGFSPLRILRKRNKALKKIRKLQKRGLIQMTPKGFICTSDGFKDSDEELDNNQIEELDQPINTTDLPFDIDWNGDLPLNITIPKISLHSLILDFSAVSFLDVSSMRGLRTILQEFIRIKVDVYIVGTDDDFIDKLARCEFFDDEVTDSIFFLTIHDAILHILMKKDYSTSKFNSSQEKERKFDFTINTNGGLRNRECQVPVETKF |
Keywords
- Cellular component
Phenotypes & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 37 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000080162 | 1-757 | Chloride anion exchanger | |||
Sequence: MIEAIGNQYVVARPVYSTKTFGEEFKKTHRHHKTFLDHLKGCCSCSSQKAKKIALSLFPIASWLPAYKIKEWLLSDIVSGISTGLVAVLQGLAFALLVNIPPAYGLYAAFFPVITYFFLGTSRHISVGPFPVLSMMVGVVVTRVVSDPNASSELSSSSTENDSFIEEKVMVAASVTVLSGIIQLLLGVLQVGFVVIYLSESLISGFTTAAAIHVLVSQLKFMLQLPVPAYSDPFSIFKVLESVFTQIQKTNIADLVTSVIILVVVFVFKEINQRYRSKLPVPIPIELIMTVIATGVSYGCNFEDRFGVAVVGNMSLGFQPPITPSVEVFQDTIGDSFGIAIVGFAVAFSVASVYSLKYDYPIDGNQELIALGVSNIFTGAFKGFAGSTALSRSGVQESTGGKTQVAGLLSAVIVLIVIVAIGFLLQPLQKSVLAALALGNLKGMLMQFAEIGRLWKKDKYDCLIWIMTFIFAIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANVGRSNIYKNKKNYAEVYEPEGVKIFRCPSPIYFANIGFFKQKLIDAVGFSPLRILRKRNKALKKIRKLQKRGLIQMTPKGFICTSDGFKDSDEELDNNQIEELDQPINTTDLPFDIDWNGDLPLNITIPKISLHSLILDFSAVSFLDVSSMRGLRTILQEFIRIKVDVYIVGTDDDFIDKLARCEFFDDEVTDSIFFLTIHDAILHILMKKDYSTSKFNSSQEKERKFDFTINTNGGLRNRECQVPVETKF | ||||||
Glycosylation | 149 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 161 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Post-translational modification
N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation.
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Interacts with PDZK1 (By similarity).
Interacts with CFTR, SLC26A6 and NHERF1 (PubMed:21976599).
Interacts (via PDZ-binding motif) with NHERF4 (via the third PDZ domain) (PubMed:22627094).
This interaction leads to decreased expression of SLC26A3 on the cell membrane resulting in its reduced exchanger activity (By similarity).
Interacts with CFTR, SLC26A6 and NHERF1 (PubMed:21976599).
Interacts (via PDZ-binding motif) with NHERF4 (via the third PDZ domain) (PubMed:22627094).
This interaction leads to decreased expression of SLC26A3 on the cell membrane resulting in its reduced exchanger activity (By similarity).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9WVC8 | Cftr P26361 | 3 | EBI-6895537, EBI-6115317 | |
BINARY | Q9WVC8 | Nherf1 P70441 | 2 | EBI-6895537, EBI-1184085 | |
BINARY | Q9WVC8 | Slc26a6 Q8CIW6 | 2 | EBI-6895537, EBI-6895517 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 518-713 | STAS | ||||
Sequence: NYAEVYEPEGVKIFRCPSPIYFANIGFFKQKLIDAVGFSPLRILRKRNKALKKIRKLQKRGLIQMTPKGFICTSDGFKDSDEELDNNQIEELDQPINTTDLPFDIDWNGDLPLNITIPKISLHSLILDFSAVSFLDVSSMRGLRTILQEFIRIKVDVYIVGTDDDFIDKLARCEFFDDEVTDSIFFLTIHDAILHI | ||||||
Motif | 754-757 | PDZ-binding | ||||
Sequence: ETKF |
Sequence similarities
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length757
- Mass (Da)83,590
- Last updated1999-11-01 v1
- Checksum32B1AC648BE74A07
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF136751 EMBL· GenBank· DDBJ | AAD42784.1 EMBL· GenBank· DDBJ | mRNA | ||
BC139271 EMBL· GenBank· DDBJ | AAI39272.1 EMBL· GenBank· DDBJ | mRNA | ||
BC139273 EMBL· GenBank· DDBJ | AAI39274.1 EMBL· GenBank· DDBJ | mRNA |