Q9WVC8 · S26A3_MOUSE

  • Protein
    Chloride anion exchanger
  • Gene
    Slc26a3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:10428871).
Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:21976599).

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbrush border membrane
Cellular Componentmembrane
Cellular Componentplasma membrane
Cellular Componentsperm midpiece
Molecular Functionbicarbonate transmembrane transporter activity
Molecular Functionchloride transmembrane transporter activity
Molecular Functionchloride:bicarbonate antiporter activity
Molecular Functionoxalate transmembrane transporter activity
Molecular Functionsecondary active sulfate transmembrane transporter activity
Molecular Functionsulfate transmembrane transporter activity
Biological Processcellular response to cAMP
Biological Processintracellular pH elevation
Biological Processmembrane hyperpolarization
Biological Processsperm capacitation

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Chloride anion exchanger
  • Alternative names
    • Down-regulated in adenoma (Protein DRA)
    • Solute carrier family 26 member 3

Gene names

    • Name
      Slc26a3
    • Synonyms
      Dra

Organism names

  • Taxonomic identifier
  • Strain
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9WVC8
  • Secondary accessions
    • B2RTD9

Proteomes

Organism-specific databases

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein
Cell membrane
; Multi-pass membrane protein
Note: Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-71Cytoplasmic
Transmembrane72-92Helical
Topological domain93Extracellular
Transmembrane94-114Helical
Topological domain115-124Cytoplasmic
Transmembrane125-145Helical
Topological domain146-176Extracellular
Transmembrane177-197Helical
Topological domain198-201Cytoplasmic
Transmembrane202-222Helical
Topological domain223-250Extracellular
Transmembrane251-271Helical
Topological domain272-278Cytoplasmic
Transmembrane279-299Helical
Topological domain300-335Extracellular
Transmembrane336-356Helical
Topological domain357-367Cytoplasmic
Transmembrane368-388Helical
Topological domain389-404Extracellular
Transmembrane405-425Helical
Topological domain426-462Cytoplasmic
Transmembrane463-483Helical
Topological domain484-757Extracellular

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 37 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00000801621-757Chloride anion exchanger
Glycosylation149N-linked (GlcNAc...) asparagine
Glycosylation161N-linked (GlcNAc...) asparagine

Post-translational modification

N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in spermatogenic cells (PubMed:21976599).
Expressed at high levels in cecum and colon and at lower levels in small intestine (PubMed:10428871).

Gene expression databases

Interaction

Subunit

Interacts with PDZK1 (By similarity).
Interacts with CFTR, SLC26A6 and NHERF1 (PubMed:21976599).
Interacts (via PDZ-binding motif) with NHERF4 (via the third PDZ domain) (PubMed:22627094).
This interaction leads to decreased expression of SLC26A3 on the cell membrane resulting in its reduced exchanger activity (By similarity).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9WVC8Cftr P263613EBI-6895537, EBI-6115317
BINARY Q9WVC8Nherf1 P704412EBI-6895537, EBI-1184085
BINARY Q9WVC8Slc26a6 Q8CIW62EBI-6895537, EBI-6895517

Protein-protein interaction databases

Chemistry

Miscellaneous

Family & Domains

Features

Showing features for domain, motif.

TypeIDPosition(s)Description
Domain518-713STAS
Motif754-757PDZ-binding

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    757
  • Mass (Da)
    83,590
  • Last updated
    1999-11-01 v1
  • Checksum
    32B1AC648BE74A07
MIEAIGNQYVVARPVYSTKTFGEEFKKTHRHHKTFLDHLKGCCSCSSQKAKKIALSLFPIASWLPAYKIKEWLLSDIVSGISTGLVAVLQGLAFALLVNIPPAYGLYAAFFPVITYFFLGTSRHISVGPFPVLSMMVGVVVTRVVSDPNASSELSSSSTENDSFIEEKVMVAASVTVLSGIIQLLLGVLQVGFVVIYLSESLISGFTTAAAIHVLVSQLKFMLQLPVPAYSDPFSIFKVLESVFTQIQKTNIADLVTSVIILVVVFVFKEINQRYRSKLPVPIPIELIMTVIATGVSYGCNFEDRFGVAVVGNMSLGFQPPITPSVEVFQDTIGDSFGIAIVGFAVAFSVASVYSLKYDYPIDGNQELIALGVSNIFTGAFKGFAGSTALSRSGVQESTGGKTQVAGLLSAVIVLIVIVAIGFLLQPLQKSVLAALALGNLKGMLMQFAEIGRLWKKDKYDCLIWIMTFIFAIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANVGRSNIYKNKKNYAEVYEPEGVKIFRCPSPIYFANIGFFKQKLIDAVGFSPLRILRKRNKALKKIRKLQKRGLIQMTPKGFICTSDGFKDSDEELDNNQIEELDQPINTTDLPFDIDWNGDLPLNITIPKISLHSLILDFSAVSFLDVSSMRGLRTILQEFIRIKVDVYIVGTDDDFIDKLARCEFFDDEVTDSIFFLTIHDAILHILMKKDYSTSKFNSSQEKERKFDFTINTNGGLRNRECQVPVETKF

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9QAZ3E9QAZ3_MOUSESlc26a3235
E9PY22E9PY22_MOUSESlc26a358

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF136751
EMBL· GenBank· DDBJ
AAD42784.1
EMBL· GenBank· DDBJ
mRNA
BC139271
EMBL· GenBank· DDBJ
AAI39272.1
EMBL· GenBank· DDBJ
mRNA
BC139273
EMBL· GenBank· DDBJ
AAI39274.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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