Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation.Amato R., D'Antona L., Porciatti G., Agosti V., Menniti M., Rinaldo C., Costa N., Bellacchio E., Mattarocci S.[...], Perrotti N.View abstractCited forFUNCTION IN PHOSPHORYLATION OF MDM2CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Mol. Med. 87:1221-1239 (2009)Cited in3Mapped to99+
The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion.Scortegagna M., Berthon A., Settas N., Giannakou A., Garcia G., Li J.L., James B., Liddington R.C., Vilches-Moure J.G.[...], Ronai Z.A.View abstractCategoriesFunction, PTM / ProcessingSourceMGI: 1340062PubMedEurope PMCJCI Insight 2:97128-97128 (2017)Mapped to99+
Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2.Edinger R.S., Lebowitz J., Li H., Alzamora R., Wang H., Johnson J.P., Hallows K.R.View abstractAnnotationENaC-beta regulation that occurs through IKKbeta-dependent Nedd4-2 phosphorylation at a recognized SGK1 and protein kinase A target site.CategoriesPTM / ProcessingSourceGeneRif: 20393, MGI: 1340062PubMedEurope PMCJ Biol Chem 284:150-157 (2009)Cited in1Mapped to63