Transcriptomic Profile Identifies Hippocampal Sgk1 as the Key Mediator of Ovarian Estrogenic Regulation on Spatial Learning and Memory and Abeta Accumulation.
Serum- and Glucocorticoid-Inducible Kinase 1 Promotes Alternative Macrophage Polarization and Restrains Inflammation through FoxO1 and STAT3 Signaling.
Aortic calcification stiffness and osteo-/chondrogenic transdifferentiation following cholecalciferol overload were strongly reduced by genetic knockout or pharmacological inhibition of Sgk1. Similarly Sgk1 deficiency blunted vascular calcification in apolipoprotein E-deficient mice after subtotal nephrectomy.
results suggest that SGK1 may play a critical role in the inflammatory cascade of cardiac fibroblasts triggered by mechanical stretch; SGK1 could be used as a potential target for treatment of cardiac fibrosis and heart failure
adaptive molecular responses of glucocorticoid-responsive gene expression and SGK1 in prefrontal cortex may contribute to mechanisms underlying behavioral responses to chronic ethanol exposure, Phosphorylation
SGK1 is strongly stimulated by glucocorticoids in pituitary corticotrophs; however its effects on POMC transcription are antagonistic to the classical inhibitory glucocorticoid action
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