sgk is an aldosterone-induced kinase in the renal collecting duct. Effects on epithelial Na+ channels.Naray-Fejes-Toth A., Canessa C., Cleaveland E.S., Aldrich G., Fejes-Toth G.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 274:16973-16978 (1999)Cited in2Mapped to7
Regulation of sgk by aldosterone and its effects on the epithelial Na(+) channel.Shigaev A., Asher C., Latter H., Garty H., Reuveny E.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)StrainC57BL/6JTissuePlacentaCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCAm. J. Physiol. 278:F613-F619 (2000)Cited in1
The transcriptional landscape of the mammalian genome.Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B.[...], Hayashizaki Y.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)StrainC57BL/6JTissueBrain, PlacentaCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 309:1559-1563 (2005)Cited in99+16Mapped to99+
No title available.Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.Cited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (SEP-2005)Cited in99+12
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)StrainC57BL/6J, FVB/NTissueBrainCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
p53 stimulates promoter activity of the sgk. serum/glucocorticoid- inducible serine/threonine protein kinase gene in rodent mammary epithelial cells.Maiyar A.C., Huang A.J., Phu P.T., Cha H.H., Firestone G.L.View abstractCited forREGULATION BY P53TissueMammary epitheliumCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 271:12414-12422 (1996)Cited in2
Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells.Leong M.L.L., Maiyar A.C., Kim B., O'Keeffe B.A., Firestone G.L.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 278:5871-5882 (2003)Cited in1Mapped to3
Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A.Yoo D., Kim B.Y., Campo C., Nance L., King A., Maouyo D., Welling P.A.View abstractCited forFUNCTION IN PHOSPHORYLATION OF KCNJ1/ROMK1CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 278:23066-23075 (2003)Cited in2Mapped to13
Glucocorticoid adrenal steroids and glucocorticoid-inducible kinase isoforms in the regulation of GluR6 expression.Strutz-Seebohm N., Seebohm G., Shumilina E., Mack A.F., Wagner H.J., Lampert A., Grahammer F., Henke G., Just L.[...], Lang F.View abstractCited forFUNCTION IN REGULATION OF GRIK2/GLUR6CategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Physiol. (Lond. ) 565:391-401 (2005)Cited in3Mapped to3
Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation.Amato R., D'Antona L., Porciatti G., Agosti V., Menniti M., Rinaldo C., Costa N., Bellacchio E., Mattarocci S.[...], Perrotti N.View abstractCited forFUNCTION IN PHOSPHORYLATION OF MDM2CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Mol. Med. 87:1221-1239 (2009)Cited in3Mapped to99+
Serum and glucocorticoid-inducible kinase 1 (SGK1) is necessary for vascular remodeling during angiogenesis.Catela C., Kratsios P., Hede M., Lang F., Rosenthal N.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCDev. Dyn. 239:2149-2160 (2010)Cited in1Mapped to61
Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.Heise C.J., Xu B.E., Deaton S.L., Cha S.K., Cheng C.J., Earnest S., Sengupta S., Juang Y.C., Stippec S.[...], Cobb M.H.View abstractCited forACTIVITY REGULATIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 285:25161-25167 (2010)Cited in8Mapped to28
Serum- and glucocorticoid-inducible kinase 1 (SGK1) regulates adipocyte differentiation via forkhead box O1.Di Pietro N., Panel V., Hayes S., Bagattin A., Meruvu S., Pandolfi A., Hugendubler L., Fejes-Toth G., Naray-Fejes-Toth A., Mueller E.View abstractCited forFUNCTION IN PHOSPHORYLATION OF FOXO1CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Endocrinol. 24:370-380 (2010)Cited in2Mapped to11
Stimulation of Ca2+-channel Orai1/STIM1 by serum- and glucocorticoid- inducible kinase 1 (SGK1).Eylenstein A., Gehring E.M., Heise N., Shumilina E., Schmidt S., Szteyn K., Muenzer P., Nurbaeva M.K., Eichenmueller M.[...], Lang F.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCFASEB J. 25:2012-2021 (2011)Cited in1Mapped to7
mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel.Lu M., Wang J., Ives H.E., Pearce D.View abstractCited forFUNCTION, INTERACTION WITH MAPKAP1/SIN1CategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 286:30647-30654 (2011)Cited in2Mapped to32
Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase.Mo J.S., Ann E.J., Yoon J.H., Jung J., Choi Y.H., Kim H.Y., Ahn J.S., Kim S.M., Kim M.Y.[...], Park H.S.View abstractCited forFUNCTION IN PHOSPHORYLATION OF FBXW7, INTERACTION WITH NOTCH1 AND FBXW7CategoriesFunction, PTM / Processing, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Cell Sci. 124:100-112 (2011)Cited in3Mapped to39
Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids.He P., Lee S.J., Lin S., Seidler U., Lang F., Fejes-Toth G., Naray-Fejes-Toth A., Yun C.C.View abstractCited forFUNCTION IN REGULATION OF SLC9A3/NHE3, SUBCELLULAR LOCATIONCategoriesFunction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Biol. Cell 22:3812-3825 (2011)Cited in6Mapped to20
Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.Harrison S.M., Dunwoodie S.L., Arkell R.M., Lehrach H., Beddington R.S.View abstractCategoriesSequencesSourceMGI: 1340062PubMedEurope PMCDevelopment 121:2479-2489 (1995)Mapped to70
Integrating analysis of mRNA expression profiles indicates Sgk1 as a key mediator in muscle-brain crosstalk during resistance exercise.Liu Y., Ye Q., Dai Y., Hu J., Chen J., Dong J., Li H., Dou Z.View abstractAnnotationIntegrating analysis of mRNA expression profiles indicates Sgk1 as a key mediator in muscle-brain crosstalk during resistance exercise.CategoriesPTM / Processing, Subcellular LocationSourceGeneRif: 20393PubMedEurope PMCBiochem Biophys Res Commun 719:150075-150075 (2024)Mapped to4
Endothelial cell serum and glucocorticoid regulated kinase 1 (SGK1) mediates vascular stiffening.Zhang L., Sun Z., Yang Y., Mack A., Rodgers M., Aroor A., Jia G., Sowers J.R., Hill M.A.View abstractAnnotationEndothelial cell serum and glucocorticoid regulated kinase 1 (SGK1) mediates vascular stiffening.CategoriesFunctionSourceGeneRif: 20393PubMedEurope PMCMetabolism 154:155831-155831 (2024)Mapped to4
SGLT2 knockdown restores the Th17/Treg balance and suppresses diabetic nephropathy in db/db mice by regulating SGK1 via Na.Wang D., Zhang Q., Dong W., Ren S., Wang X., Su C., Lin X., Zheng Z., Xue Y.View abstractAnnotationSGLT2 knockdown restores the Th17/Treg balance and suppresses diabetic nephropathy in db/db mice by regulating SGK1 via Na.CategoriesFunctionSourceGeneRif: 20393PubMedEurope PMCMol Cell Endocrinol 584:112156-112156 (2024)Mapped to6
SGK1 aggravates idiopathic pulmonary fibrosis by triggering H3k27ac- mediated macrophage reprogramming and disturbing immune homeostasis.Wu J., Gong L., Li Y., Liu T., Sun R., Jia K., Liu R., Dong F., Gu X., Li X.View abstractAnnotationSGK1 aggravates idiopathic pulmonary fibrosis by triggering H3k27ac-mediated macrophage reprogramming and disturbing immune homeostasis.CategoriesFunctionSourceGeneRif: 20393PubMedEurope PMCInt J Biol Sci 20:968-986 (2024)Mapped to12
The role of serum/glucocorticoid-regulated kinase 1 in brain function following cerebral ischemia.Wu C.Y., Zhang Y., Xu L., Huang Z., Zou P., Clemons G.A., Li C., Citadin C.T., Zhang Q., Lee R.H.View abstractAnnotationThe role of serum/glucocorticoid-regulated kinase 1 in brain function following cerebral ischemia.SourceGeneRif: 20393PubMedEurope PMCJ Cereb Blood Flow Metab 44:1145-1162 (2024)Mapped to4
SGK1 is involved in doxorubicin-induced chronic cardiotoxicity and dysfunction through activation of the NFkappaB pathway.Zhang Y., Zhang D., Meng T., Tian P., Chen J., Liu A., Zheng Y., Su G.View abstractAnnotationSGK1 is involved in doxorubicin-induced chronic cardiotoxicity and dysfunction through activation of the NFkappaB pathway.CategoriesFunctionSourceGeneRif: 20393PubMedEurope PMCInt Immunopharmacol 125:111151-111151 (2023)Mapped to6
Renal tubular SGK1 is required to achieve blood pressure surge and circadian rhythm.Staub O., Debonneville A., Stifanelli M., Juffre A., Maillard M.P., Gumz M.L., Al-Qusairi L.View abstractAnnotationRenal tubular SGK1 is required to achieve blood pressure surge and circadian rhythm.CategoriesFunctionSourceGeneRif: 20393PubMedEurope PMCAm J Physiol Renal Physiol 325:F629-F637 (2023)Mapped to4